Maternal high-fat diet during pregnancy or lactation changes the somatic and neurological development of the offspring

Detalhes bibliográficos
Autor(a) principal: Mendes-da-Silva,Cristiano
Data de Publicação: 2014
Outros Autores: Giriko,Catherine Ássuka, Mennitti,Laís Vales, Hosoume,Lilian Fazion, Souto,Tayane dos Santos, Silva,Alexandre Valotta da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000200136
Resumo: The maternal exposure to high fat diet (HFD) during pregnancy and breastfeeding have been considered an important inducer of alterations in offspring normal programming, both in animals and humans, and may disturb brain development. In the present study we investigated the somatic and sensory-motor development of the offspring from rat dams fed a HFD, compared with dams fed a control diet, during pregnancy or lactation. Indicators of the body growth, physical maturation, and reflex ontogeny were evaluated. Offspring of dams fed a HFD showed reduced weight and body growth, delayed physical maturation, and delayed maturation of the physiological reflexes, such as vibrissa placing, auditory startle response, and free-fall righting. Our findings suggest that maternal HFD during pregnancy or lactation modifies somatic and neurological development of the offspring, possibly increasing the risk of neuroendocrine and neuropsychiatric disorders later in life.
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spelling Maternal high-fat diet during pregnancy or lactation changes the somatic and neurological development of the offspringhigh fat dietpregnancylactationsomatic growthreflex ontogenyoffspringThe maternal exposure to high fat diet (HFD) during pregnancy and breastfeeding have been considered an important inducer of alterations in offspring normal programming, both in animals and humans, and may disturb brain development. In the present study we investigated the somatic and sensory-motor development of the offspring from rat dams fed a HFD, compared with dams fed a control diet, during pregnancy or lactation. Indicators of the body growth, physical maturation, and reflex ontogeny were evaluated. Offspring of dams fed a HFD showed reduced weight and body growth, delayed physical maturation, and delayed maturation of the physiological reflexes, such as vibrissa placing, auditory startle response, and free-fall righting. Our findings suggest that maternal HFD during pregnancy or lactation modifies somatic and neurological development of the offspring, possibly increasing the risk of neuroendocrine and neuropsychiatric disorders later in life.Academia Brasileira de Neurologia - ABNEURO2014-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000200136Arquivos de Neuro-Psiquiatria v.72 n.2 2014reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20130220info:eu-repo/semantics/openAccessMendes-da-Silva,CristianoGiriko,Catherine ÁssukaMennitti,Laís ValesHosoume,Lilian FazionSouto,Tayane dos SantosSilva,Alexandre Valotta daeng2014-03-28T00:00:00Zoai:scielo:S0004-282X2014000200136Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2014-03-28T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Maternal high-fat diet during pregnancy or lactation changes the somatic and neurological development of the offspring
title Maternal high-fat diet during pregnancy or lactation changes the somatic and neurological development of the offspring
spellingShingle Maternal high-fat diet during pregnancy or lactation changes the somatic and neurological development of the offspring
Mendes-da-Silva,Cristiano
high fat diet
pregnancy
lactation
somatic growth
reflex ontogeny
offspring
title_short Maternal high-fat diet during pregnancy or lactation changes the somatic and neurological development of the offspring
title_full Maternal high-fat diet during pregnancy or lactation changes the somatic and neurological development of the offspring
title_fullStr Maternal high-fat diet during pregnancy or lactation changes the somatic and neurological development of the offspring
title_full_unstemmed Maternal high-fat diet during pregnancy or lactation changes the somatic and neurological development of the offspring
title_sort Maternal high-fat diet during pregnancy or lactation changes the somatic and neurological development of the offspring
author Mendes-da-Silva,Cristiano
author_facet Mendes-da-Silva,Cristiano
Giriko,Catherine Ássuka
Mennitti,Laís Vales
Hosoume,Lilian Fazion
Souto,Tayane dos Santos
Silva,Alexandre Valotta da
author_role author
author2 Giriko,Catherine Ássuka
Mennitti,Laís Vales
Hosoume,Lilian Fazion
Souto,Tayane dos Santos
Silva,Alexandre Valotta da
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Mendes-da-Silva,Cristiano
Giriko,Catherine Ássuka
Mennitti,Laís Vales
Hosoume,Lilian Fazion
Souto,Tayane dos Santos
Silva,Alexandre Valotta da
dc.subject.por.fl_str_mv high fat diet
pregnancy
lactation
somatic growth
reflex ontogeny
offspring
topic high fat diet
pregnancy
lactation
somatic growth
reflex ontogeny
offspring
description The maternal exposure to high fat diet (HFD) during pregnancy and breastfeeding have been considered an important inducer of alterations in offspring normal programming, both in animals and humans, and may disturb brain development. In the present study we investigated the somatic and sensory-motor development of the offspring from rat dams fed a HFD, compared with dams fed a control diet, during pregnancy or lactation. Indicators of the body growth, physical maturation, and reflex ontogeny were evaluated. Offspring of dams fed a HFD showed reduced weight and body growth, delayed physical maturation, and delayed maturation of the physiological reflexes, such as vibrissa placing, auditory startle response, and free-fall righting. Our findings suggest that maternal HFD during pregnancy or lactation modifies somatic and neurological development of the offspring, possibly increasing the risk of neuroendocrine and neuropsychiatric disorders later in life.
publishDate 2014
dc.date.none.fl_str_mv 2014-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000200136
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000200136
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282X20130220
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.72 n.2 2014
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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