Migraine improvement correlates with posterior cingulate cortical thickness reduction
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000300150 |
Resumo: | ABSTRACT Objective The main goal of this study was to correlate migraine improvement, after prophylactic therapy, with cortical thickness changes. Methods Cortical thickness maps were obtained with magnetic resonance imaging (MRI) from 19 patients with migraine before (first scan) and after (second scan) prophylactic treatment, and these were compared with controls using the FreeSurfer MRI tool. Cortical changes were correlated with the headache index (HI). Results Anincrease incortical thickness was found in the right cuneus and precuneus, somatosensory and superior parietal cortices in both patient scans, compared with the controls. No changes were observed in the left hemisphere. Following correction for multiple comparisons, no areas changed from the first to the second scan. Regression analysis showed a significant negative correlation between the HI improvement and cortical thickness changes in the left posterior cingulate, a region involved with nociception and, possibly, the development of chronic pain. Conclusion There were changes in cortical thickness in patients with migraine relative to controls in areas involved with vision and pain processing. Left posterior cingulate cortical changes correlated with headache frequency and intensity. |
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Arquivos de neuro-psiquiatria (Online) |
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Migraine improvement correlates with posterior cingulate cortical thickness reductionmigraine disordersmagnetic resonance imaging - FreeSurferprophylactic treatmentABSTRACT Objective The main goal of this study was to correlate migraine improvement, after prophylactic therapy, with cortical thickness changes. Methods Cortical thickness maps were obtained with magnetic resonance imaging (MRI) from 19 patients with migraine before (first scan) and after (second scan) prophylactic treatment, and these were compared with controls using the FreeSurfer MRI tool. Cortical changes were correlated with the headache index (HI). Results Anincrease incortical thickness was found in the right cuneus and precuneus, somatosensory and superior parietal cortices in both patient scans, compared with the controls. No changes were observed in the left hemisphere. Following correction for multiple comparisons, no areas changed from the first to the second scan. Regression analysis showed a significant negative correlation between the HI improvement and cortical thickness changes in the left posterior cingulate, a region involved with nociception and, possibly, the development of chronic pain. Conclusion There were changes in cortical thickness in patients with migraine relative to controls in areas involved with vision and pain processing. Left posterior cingulate cortical changes correlated with headache frequency and intensity.Academia Brasileira de Neurologia - ABNEURO2018-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000300150Arquivos de Neuro-Psiquiatria v.76 n.3 2018reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20180004info:eu-repo/semantics/openAccessAmaral,Vanise C. G.Tukamoto,GustavoKubo,TadeuLuiz,Ronir RaggioGasparetto,EmersonVincent,Maurice B.eng2018-06-26T00:00:00Zoai:scielo:S0004-282X2018000300150Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2018-06-26T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Migraine improvement correlates with posterior cingulate cortical thickness reduction |
title |
Migraine improvement correlates with posterior cingulate cortical thickness reduction |
spellingShingle |
Migraine improvement correlates with posterior cingulate cortical thickness reduction Amaral,Vanise C. G. migraine disorders magnetic resonance imaging - FreeSurfer prophylactic treatment |
title_short |
Migraine improvement correlates with posterior cingulate cortical thickness reduction |
title_full |
Migraine improvement correlates with posterior cingulate cortical thickness reduction |
title_fullStr |
Migraine improvement correlates with posterior cingulate cortical thickness reduction |
title_full_unstemmed |
Migraine improvement correlates with posterior cingulate cortical thickness reduction |
title_sort |
Migraine improvement correlates with posterior cingulate cortical thickness reduction |
author |
Amaral,Vanise C. G. |
author_facet |
Amaral,Vanise C. G. Tukamoto,Gustavo Kubo,Tadeu Luiz,Ronir Raggio Gasparetto,Emerson Vincent,Maurice B. |
author_role |
author |
author2 |
Tukamoto,Gustavo Kubo,Tadeu Luiz,Ronir Raggio Gasparetto,Emerson Vincent,Maurice B. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Amaral,Vanise C. G. Tukamoto,Gustavo Kubo,Tadeu Luiz,Ronir Raggio Gasparetto,Emerson Vincent,Maurice B. |
dc.subject.por.fl_str_mv |
migraine disorders magnetic resonance imaging - FreeSurfer prophylactic treatment |
topic |
migraine disorders magnetic resonance imaging - FreeSurfer prophylactic treatment |
description |
ABSTRACT Objective The main goal of this study was to correlate migraine improvement, after prophylactic therapy, with cortical thickness changes. Methods Cortical thickness maps were obtained with magnetic resonance imaging (MRI) from 19 patients with migraine before (first scan) and after (second scan) prophylactic treatment, and these were compared with controls using the FreeSurfer MRI tool. Cortical changes were correlated with the headache index (HI). Results Anincrease incortical thickness was found in the right cuneus and precuneus, somatosensory and superior parietal cortices in both patient scans, compared with the controls. No changes were observed in the left hemisphere. Following correction for multiple comparisons, no areas changed from the first to the second scan. Regression analysis showed a significant negative correlation between the HI improvement and cortical thickness changes in the left posterior cingulate, a region involved with nociception and, possibly, the development of chronic pain. Conclusion There were changes in cortical thickness in patients with migraine relative to controls in areas involved with vision and pain processing. Left posterior cingulate cortical changes correlated with headache frequency and intensity. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000300150 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000300150 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282x20180004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.76 n.3 2018 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212783678816256 |