Migraine improvement correlates with posterior cingulate cortical thickness reduction

Detalhes bibliográficos
Autor(a) principal: Amaral,Vanise C. G.
Data de Publicação: 2018
Outros Autores: Tukamoto,Gustavo, Kubo,Tadeu, Luiz,Ronir Raggio, Gasparetto,Emerson, Vincent,Maurice B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000300150
Resumo: ABSTRACT Objective The main goal of this study was to correlate migraine improvement, after prophylactic therapy, with cortical thickness changes. Methods Cortical thickness maps were obtained with magnetic resonance imaging (MRI) from 19 patients with migraine before (first scan) and after (second scan) prophylactic treatment, and these were compared with controls using the FreeSurfer MRI tool. Cortical changes were correlated with the headache index (HI). Results Anincrease incortical thickness was found in the right cuneus and precuneus, somatosensory and superior parietal cortices in both patient scans, compared with the controls. No changes were observed in the left hemisphere. Following correction for multiple comparisons, no areas changed from the first to the second scan. Regression analysis showed a significant negative correlation between the HI improvement and cortical thickness changes in the left posterior cingulate, a region involved with nociception and, possibly, the development of chronic pain. Conclusion There were changes in cortical thickness in patients with migraine relative to controls in areas involved with vision and pain processing. Left posterior cingulate cortical changes correlated with headache frequency and intensity.
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spelling Migraine improvement correlates with posterior cingulate cortical thickness reductionmigraine disordersmagnetic resonance imaging - FreeSurferprophylactic treatmentABSTRACT Objective The main goal of this study was to correlate migraine improvement, after prophylactic therapy, with cortical thickness changes. Methods Cortical thickness maps were obtained with magnetic resonance imaging (MRI) from 19 patients with migraine before (first scan) and after (second scan) prophylactic treatment, and these were compared with controls using the FreeSurfer MRI tool. Cortical changes were correlated with the headache index (HI). Results Anincrease incortical thickness was found in the right cuneus and precuneus, somatosensory and superior parietal cortices in both patient scans, compared with the controls. No changes were observed in the left hemisphere. Following correction for multiple comparisons, no areas changed from the first to the second scan. Regression analysis showed a significant negative correlation between the HI improvement and cortical thickness changes in the left posterior cingulate, a region involved with nociception and, possibly, the development of chronic pain. Conclusion There were changes in cortical thickness in patients with migraine relative to controls in areas involved with vision and pain processing. Left posterior cingulate cortical changes correlated with headache frequency and intensity.Academia Brasileira de Neurologia - ABNEURO2018-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000300150Arquivos de Neuro-Psiquiatria v.76 n.3 2018reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20180004info:eu-repo/semantics/openAccessAmaral,Vanise C. G.Tukamoto,GustavoKubo,TadeuLuiz,Ronir RaggioGasparetto,EmersonVincent,Maurice B.eng2018-06-26T00:00:00Zoai:scielo:S0004-282X2018000300150Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2018-06-26T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Migraine improvement correlates with posterior cingulate cortical thickness reduction
title Migraine improvement correlates with posterior cingulate cortical thickness reduction
spellingShingle Migraine improvement correlates with posterior cingulate cortical thickness reduction
Amaral,Vanise C. G.
migraine disorders
magnetic resonance imaging - FreeSurfer
prophylactic treatment
title_short Migraine improvement correlates with posterior cingulate cortical thickness reduction
title_full Migraine improvement correlates with posterior cingulate cortical thickness reduction
title_fullStr Migraine improvement correlates with posterior cingulate cortical thickness reduction
title_full_unstemmed Migraine improvement correlates with posterior cingulate cortical thickness reduction
title_sort Migraine improvement correlates with posterior cingulate cortical thickness reduction
author Amaral,Vanise C. G.
author_facet Amaral,Vanise C. G.
Tukamoto,Gustavo
Kubo,Tadeu
Luiz,Ronir Raggio
Gasparetto,Emerson
Vincent,Maurice B.
author_role author
author2 Tukamoto,Gustavo
Kubo,Tadeu
Luiz,Ronir Raggio
Gasparetto,Emerson
Vincent,Maurice B.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Amaral,Vanise C. G.
Tukamoto,Gustavo
Kubo,Tadeu
Luiz,Ronir Raggio
Gasparetto,Emerson
Vincent,Maurice B.
dc.subject.por.fl_str_mv migraine disorders
magnetic resonance imaging - FreeSurfer
prophylactic treatment
topic migraine disorders
magnetic resonance imaging - FreeSurfer
prophylactic treatment
description ABSTRACT Objective The main goal of this study was to correlate migraine improvement, after prophylactic therapy, with cortical thickness changes. Methods Cortical thickness maps were obtained with magnetic resonance imaging (MRI) from 19 patients with migraine before (first scan) and after (second scan) prophylactic treatment, and these were compared with controls using the FreeSurfer MRI tool. Cortical changes were correlated with the headache index (HI). Results Anincrease incortical thickness was found in the right cuneus and precuneus, somatosensory and superior parietal cortices in both patient scans, compared with the controls. No changes were observed in the left hemisphere. Following correction for multiple comparisons, no areas changed from the first to the second scan. Regression analysis showed a significant negative correlation between the HI improvement and cortical thickness changes in the left posterior cingulate, a region involved with nociception and, possibly, the development of chronic pain. Conclusion There were changes in cortical thickness in patients with migraine relative to controls in areas involved with vision and pain processing. Left posterior cingulate cortical changes correlated with headache frequency and intensity.
publishDate 2018
dc.date.none.fl_str_mv 2018-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000300150
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000300150
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282x20180004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.76 n.3 2018
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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