Binswanger's disease and quantitative fractional anisotropy

• Autor(a) principal: Engelhardt,Eliasz
• Data de Publicação: 2009
• Outros Autores: Moreira,Denise Madeira, Alves,Gilberto Sousa, Lanna,Maria Elisa Oliveira, Alves,Carlos Eduardo de Oliveira, Ericeira-Valente,Letice, Sudo,Felipe Kenji, Laks,Jerson
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos de neuro-psiquiatria (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000200002
• topic: Binswanger's disease; white matter; leukoaraiosis; diffusion tensor; fractional anisotropy

OBJECTIVE: To study the integrity of the white matter in Binswanger's disease (BD) patients with quantitative fractional anisotropy (DTI-FA). METHOD: Controls (12) and patients with BD (12) were included. Scans performed with MR (GE Signa Horizon/1.5T). Fazekas's score=6 with white matter hyperintensities extension >75% assessed on FLAIR scans. Standard parameters for DTI-FA were used. ROIs placed in symmetrical regions on two axial planes, data pooled in anterior (frontal) and posterior (temporo-parieto-occipital) regions. Analysis with Functool. Statistics for anterior and posterior regions comparison. RESULTS: DTI-FA showed reduction of anisotropy, reflecting axonal damage and demyelination of fibers, more prominent in anterior in relation to posterior region, in BD patients in comparison to controls. CONCLUSION: Loss of integrity of fiber tracts reflects interruption of neural networks that subserve cognitive, behavioral, and motor integration. The more severely affected frontal region is related to executive dysfunction, a characteristic feature of Binswanger's disease.