Expression of nestin and vimentin in gliomatosis cerebri
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000500015 |
Resumo: | Gliomatosis cerebri (GC) is a rare form of CNS neoplasia in which there is diffuse involvement of the nervous tissue with or without the presence of tumor mass. The origin of the tumor is unknown, nor whether it represents a disease with diffuse onset or infiltration from a neoplastic focus. Here we studied the histopathologic characteristics of 6 cases with a diagnosis of GC and performed an immunohistochemical analysis using glial fibrillary acidic protein (GFAP), synaptophysin, nestin and vimentin. Most tumor cells were negative for GFAP, even though there were foci of positivity for this marker in all cases. We detected the presence of many positive cells for nestin and vimentin in all studied samples. The presence of these cells may indicate origin of the tumor from undifferentiated cells with a high degree of mobility. |
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Arquivos de neuro-psiquiatria (Online) |
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Expression of nestin and vimentin in gliomatosis cerebrigliomatosis cerebrinestinstem cellbrain tumorneuropathologyGliomatosis cerebri (GC) is a rare form of CNS neoplasia in which there is diffuse involvement of the nervous tissue with or without the presence of tumor mass. The origin of the tumor is unknown, nor whether it represents a disease with diffuse onset or infiltration from a neoplastic focus. Here we studied the histopathologic characteristics of 6 cases with a diagnosis of GC and performed an immunohistochemical analysis using glial fibrillary acidic protein (GFAP), synaptophysin, nestin and vimentin. Most tumor cells were negative for GFAP, even though there were foci of positivity for this marker in all cases. We detected the presence of many positive cells for nestin and vimentin in all studied samples. The presence of these cells may indicate origin of the tumor from undifferentiated cells with a high degree of mobility.Academia Brasileira de Neurologia - ABNEURO2006-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000500015Arquivos de Neuro-Psiquiatria v.64 n.3b 2006reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2006000500015info:eu-repo/semantics/openAccessHilbig,ArleteBarbosa-Coutinho,Lígia MariaToscani,NadimaRibeiro,Marlise de CastroCunha,Bartira Silveira Campos daeng2006-10-10T00:00:00Zoai:scielo:S0004-282X2006000500015Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2006-10-10T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Expression of nestin and vimentin in gliomatosis cerebri |
title |
Expression of nestin and vimentin in gliomatosis cerebri |
spellingShingle |
Expression of nestin and vimentin in gliomatosis cerebri Hilbig,Arlete gliomatosis cerebri nestin stem cell brain tumor neuropathology |
title_short |
Expression of nestin and vimentin in gliomatosis cerebri |
title_full |
Expression of nestin and vimentin in gliomatosis cerebri |
title_fullStr |
Expression of nestin and vimentin in gliomatosis cerebri |
title_full_unstemmed |
Expression of nestin and vimentin in gliomatosis cerebri |
title_sort |
Expression of nestin and vimentin in gliomatosis cerebri |
author |
Hilbig,Arlete |
author_facet |
Hilbig,Arlete Barbosa-Coutinho,Lígia Maria Toscani,Nadima Ribeiro,Marlise de Castro Cunha,Bartira Silveira Campos da |
author_role |
author |
author2 |
Barbosa-Coutinho,Lígia Maria Toscani,Nadima Ribeiro,Marlise de Castro Cunha,Bartira Silveira Campos da |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Hilbig,Arlete Barbosa-Coutinho,Lígia Maria Toscani,Nadima Ribeiro,Marlise de Castro Cunha,Bartira Silveira Campos da |
dc.subject.por.fl_str_mv |
gliomatosis cerebri nestin stem cell brain tumor neuropathology |
topic |
gliomatosis cerebri nestin stem cell brain tumor neuropathology |
description |
Gliomatosis cerebri (GC) is a rare form of CNS neoplasia in which there is diffuse involvement of the nervous tissue with or without the presence of tumor mass. The origin of the tumor is unknown, nor whether it represents a disease with diffuse onset or infiltration from a neoplastic focus. Here we studied the histopathologic characteristics of 6 cases with a diagnosis of GC and performed an immunohistochemical analysis using glial fibrillary acidic protein (GFAP), synaptophysin, nestin and vimentin. Most tumor cells were negative for GFAP, even though there were foci of positivity for this marker in all cases. We detected the presence of many positive cells for nestin and vimentin in all studied samples. The presence of these cells may indicate origin of the tumor from undifferentiated cells with a high degree of mobility. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000500015 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000500015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2006000500015 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.64 n.3b 2006 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212760634261504 |