Expression of nestin and vimentin in gliomatosis cerebri

Detalhes bibliográficos
Autor(a) principal: Hilbig,Arlete
Data de Publicação: 2006
Outros Autores: Barbosa-Coutinho,Lígia Maria, Toscani,Nadima, Ribeiro,Marlise de Castro, Cunha,Bartira Silveira Campos da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000500015
Resumo: Gliomatosis cerebri (GC) is a rare form of CNS neoplasia in which there is diffuse involvement of the nervous tissue with or without the presence of tumor mass. The origin of the tumor is unknown, nor whether it represents a disease with diffuse onset or infiltration from a neoplastic focus. Here we studied the histopathologic characteristics of 6 cases with a diagnosis of GC and performed an immunohistochemical analysis using glial fibrillary acidic protein (GFAP), synaptophysin, nestin and vimentin. Most tumor cells were negative for GFAP, even though there were foci of positivity for this marker in all cases. We detected the presence of many positive cells for nestin and vimentin in all studied samples. The presence of these cells may indicate origin of the tumor from undifferentiated cells with a high degree of mobility.
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spelling Expression of nestin and vimentin in gliomatosis cerebrigliomatosis cerebrinestinstem cellbrain tumorneuropathologyGliomatosis cerebri (GC) is a rare form of CNS neoplasia in which there is diffuse involvement of the nervous tissue with or without the presence of tumor mass. The origin of the tumor is unknown, nor whether it represents a disease with diffuse onset or infiltration from a neoplastic focus. Here we studied the histopathologic characteristics of 6 cases with a diagnosis of GC and performed an immunohistochemical analysis using glial fibrillary acidic protein (GFAP), synaptophysin, nestin and vimentin. Most tumor cells were negative for GFAP, even though there were foci of positivity for this marker in all cases. We detected the presence of many positive cells for nestin and vimentin in all studied samples. The presence of these cells may indicate origin of the tumor from undifferentiated cells with a high degree of mobility.Academia Brasileira de Neurologia - ABNEURO2006-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000500015Arquivos de Neuro-Psiquiatria v.64 n.3b 2006reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2006000500015info:eu-repo/semantics/openAccessHilbig,ArleteBarbosa-Coutinho,Lígia MariaToscani,NadimaRibeiro,Marlise de CastroCunha,Bartira Silveira Campos daeng2006-10-10T00:00:00Zoai:scielo:S0004-282X2006000500015Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2006-10-10T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Expression of nestin and vimentin in gliomatosis cerebri
title Expression of nestin and vimentin in gliomatosis cerebri
spellingShingle Expression of nestin and vimentin in gliomatosis cerebri
Hilbig,Arlete
gliomatosis cerebri
nestin
stem cell
brain tumor
neuropathology
title_short Expression of nestin and vimentin in gliomatosis cerebri
title_full Expression of nestin and vimentin in gliomatosis cerebri
title_fullStr Expression of nestin and vimentin in gliomatosis cerebri
title_full_unstemmed Expression of nestin and vimentin in gliomatosis cerebri
title_sort Expression of nestin and vimentin in gliomatosis cerebri
author Hilbig,Arlete
author_facet Hilbig,Arlete
Barbosa-Coutinho,Lígia Maria
Toscani,Nadima
Ribeiro,Marlise de Castro
Cunha,Bartira Silveira Campos da
author_role author
author2 Barbosa-Coutinho,Lígia Maria
Toscani,Nadima
Ribeiro,Marlise de Castro
Cunha,Bartira Silveira Campos da
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Hilbig,Arlete
Barbosa-Coutinho,Lígia Maria
Toscani,Nadima
Ribeiro,Marlise de Castro
Cunha,Bartira Silveira Campos da
dc.subject.por.fl_str_mv gliomatosis cerebri
nestin
stem cell
brain tumor
neuropathology
topic gliomatosis cerebri
nestin
stem cell
brain tumor
neuropathology
description Gliomatosis cerebri (GC) is a rare form of CNS neoplasia in which there is diffuse involvement of the nervous tissue with or without the presence of tumor mass. The origin of the tumor is unknown, nor whether it represents a disease with diffuse onset or infiltration from a neoplastic focus. Here we studied the histopathologic characteristics of 6 cases with a diagnosis of GC and performed an immunohistochemical analysis using glial fibrillary acidic protein (GFAP), synaptophysin, nestin and vimentin. Most tumor cells were negative for GFAP, even though there were foci of positivity for this marker in all cases. We detected the presence of many positive cells for nestin and vimentin in all studied samples. The presence of these cells may indicate origin of the tumor from undifferentiated cells with a high degree of mobility.
publishDate 2006
dc.date.none.fl_str_mv 2006-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000500015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000500015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2006000500015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.64 n.3b 2006
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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