Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000600516 |
Resumo: | Objective To evaluate the association between objective short sleep duration in patients with insomnia and changes in blood parameters related to hypothalamic-pituitary-adrenal (HPA) axis activity.Method A cross-sectional pilot study was conducted in 30 middle-aged adults with chronic insomnia who were divided into 2 groups according to polysomnography (PSG) total sleep time (TST) (TST > 5h and < 5h). All patients underwent subjective analysis of sleep quality, anthropometric measurements, PSG, and determination off asting blood parameters.Results The results revealed lower sleep efficiency and higher sleep latency for those with a TST < 5h. The subjective sleep quality was worse in the TST < 5h. Significantly, higher glucose and cortisol levels were observed with a TST < 5h. Glucose, cortisol and ACTH levels were inversely correlated with the PSG total sleep time.Conclusion Patients with insomnia with objective short sleep duration had HPA-associated endocrine and metabolic imbalances chronically linked to increases in cardiovascular risk observed with this more severe insomnia phenotype. |
id |
ABNEURO-1_eb514a5b1c02d6dca4a082151a0f678e |
---|---|
oai_identifier_str |
oai:scielo:S0004-282X2015000600516 |
network_acronym_str |
ABNEURO-1 |
network_name_str |
Arquivos de neuro-psiquiatria (Online) |
repository_id_str |
|
spelling |
Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomniainsomnia disorderobjective short sleep durationhypothalamic-pituitary-adrenal axisObjective To evaluate the association between objective short sleep duration in patients with insomnia and changes in blood parameters related to hypothalamic-pituitary-adrenal (HPA) axis activity.Method A cross-sectional pilot study was conducted in 30 middle-aged adults with chronic insomnia who were divided into 2 groups according to polysomnography (PSG) total sleep time (TST) (TST > 5h and < 5h). All patients underwent subjective analysis of sleep quality, anthropometric measurements, PSG, and determination off asting blood parameters.Results The results revealed lower sleep efficiency and higher sleep latency for those with a TST < 5h. The subjective sleep quality was worse in the TST < 5h. Significantly, higher glucose and cortisol levels were observed with a TST < 5h. Glucose, cortisol and ACTH levels were inversely correlated with the PSG total sleep time.Conclusion Patients with insomnia with objective short sleep duration had HPA-associated endocrine and metabolic imbalances chronically linked to increases in cardiovascular risk observed with this more severe insomnia phenotype.Academia Brasileira de Neurologia - ABNEURO2015-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000600516Arquivos de Neuro-Psiquiatria v.73 n.6 2015reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20150053info:eu-repo/semantics/openAccessD’Aurea,CarolinaPoyares,DalvaPiovezan,Ronaldo D.Passos,Giselle SoaresTufik,SergioMello,Marco Tulio deeng2015-10-21T00:00:00Zoai:scielo:S0004-282X2015000600516Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2015-10-21T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia |
title |
Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia |
spellingShingle |
Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia D’Aurea,Carolina insomnia disorder objective short sleep duration hypothalamic-pituitary-adrenal axis |
title_short |
Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia |
title_full |
Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia |
title_fullStr |
Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia |
title_full_unstemmed |
Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia |
title_sort |
Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia |
author |
D’Aurea,Carolina |
author_facet |
D’Aurea,Carolina Poyares,Dalva Piovezan,Ronaldo D. Passos,Giselle Soares Tufik,Sergio Mello,Marco Tulio de |
author_role |
author |
author2 |
Poyares,Dalva Piovezan,Ronaldo D. Passos,Giselle Soares Tufik,Sergio Mello,Marco Tulio de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
D’Aurea,Carolina Poyares,Dalva Piovezan,Ronaldo D. Passos,Giselle Soares Tufik,Sergio Mello,Marco Tulio de |
dc.subject.por.fl_str_mv |
insomnia disorder objective short sleep duration hypothalamic-pituitary-adrenal axis |
topic |
insomnia disorder objective short sleep duration hypothalamic-pituitary-adrenal axis |
description |
Objective To evaluate the association between objective short sleep duration in patients with insomnia and changes in blood parameters related to hypothalamic-pituitary-adrenal (HPA) axis activity.Method A cross-sectional pilot study was conducted in 30 middle-aged adults with chronic insomnia who were divided into 2 groups according to polysomnography (PSG) total sleep time (TST) (TST > 5h and < 5h). All patients underwent subjective analysis of sleep quality, anthropometric measurements, PSG, and determination off asting blood parameters.Results The results revealed lower sleep efficiency and higher sleep latency for those with a TST < 5h. The subjective sleep quality was worse in the TST < 5h. Significantly, higher glucose and cortisol levels were observed with a TST < 5h. Glucose, cortisol and ACTH levels were inversely correlated with the PSG total sleep time.Conclusion Patients with insomnia with objective short sleep duration had HPA-associated endocrine and metabolic imbalances chronically linked to increases in cardiovascular risk observed with this more severe insomnia phenotype. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000600516 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000600516 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282X20150053 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.73 n.6 2015 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
_version_ |
1754212777935765504 |