Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia

Detalhes bibliográficos
Autor(a) principal: D’Aurea,Carolina
Data de Publicação: 2015
Outros Autores: Poyares,Dalva, Piovezan,Ronaldo D., Passos,Giselle Soares, Tufik,Sergio, Mello,Marco Tulio de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000600516
Resumo: Objective To evaluate the association between objective short sleep duration in patients with insomnia and changes in blood parameters related to hypothalamic-pituitary-adrenal (HPA) axis activity.Method A cross-sectional pilot study was conducted in 30 middle-aged adults with chronic insomnia who were divided into 2 groups according to polysomnography (PSG) total sleep time (TST) (TST > 5h and < 5h). All patients underwent subjective analysis of sleep quality, anthropometric measurements, PSG, and determination off asting blood parameters.Results The results revealed lower sleep efficiency and higher sleep latency for those with a TST < 5h. The subjective sleep quality was worse in the TST < 5h. Significantly, higher glucose and cortisol levels were observed with a TST < 5h. Glucose, cortisol and ACTH levels were inversely correlated with the PSG total sleep time.Conclusion Patients with insomnia with objective short sleep duration had HPA-associated endocrine and metabolic imbalances chronically linked to increases in cardiovascular risk observed with this more severe insomnia phenotype.
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spelling Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomniainsomnia disorderobjective short sleep durationhypothalamic-pituitary-adrenal axisObjective To evaluate the association between objective short sleep duration in patients with insomnia and changes in blood parameters related to hypothalamic-pituitary-adrenal (HPA) axis activity.Method A cross-sectional pilot study was conducted in 30 middle-aged adults with chronic insomnia who were divided into 2 groups according to polysomnography (PSG) total sleep time (TST) (TST > 5h and < 5h). All patients underwent subjective analysis of sleep quality, anthropometric measurements, PSG, and determination off asting blood parameters.Results The results revealed lower sleep efficiency and higher sleep latency for those with a TST < 5h. The subjective sleep quality was worse in the TST < 5h. Significantly, higher glucose and cortisol levels were observed with a TST < 5h. Glucose, cortisol and ACTH levels were inversely correlated with the PSG total sleep time.Conclusion Patients with insomnia with objective short sleep duration had HPA-associated endocrine and metabolic imbalances chronically linked to increases in cardiovascular risk observed with this more severe insomnia phenotype.Academia Brasileira de Neurologia - ABNEURO2015-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000600516Arquivos de Neuro-Psiquiatria v.73 n.6 2015reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20150053info:eu-repo/semantics/openAccessD’Aurea,CarolinaPoyares,DalvaPiovezan,Ronaldo D.Passos,Giselle SoaresTufik,SergioMello,Marco Tulio deeng2015-10-21T00:00:00Zoai:scielo:S0004-282X2015000600516Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2015-10-21T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia
title Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia
spellingShingle Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia
D’Aurea,Carolina
insomnia disorder
objective short sleep duration
hypothalamic-pituitary-adrenal axis
title_short Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia
title_full Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia
title_fullStr Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia
title_full_unstemmed Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia
title_sort Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia
author D’Aurea,Carolina
author_facet D’Aurea,Carolina
Poyares,Dalva
Piovezan,Ronaldo D.
Passos,Giselle Soares
Tufik,Sergio
Mello,Marco Tulio de
author_role author
author2 Poyares,Dalva
Piovezan,Ronaldo D.
Passos,Giselle Soares
Tufik,Sergio
Mello,Marco Tulio de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv D’Aurea,Carolina
Poyares,Dalva
Piovezan,Ronaldo D.
Passos,Giselle Soares
Tufik,Sergio
Mello,Marco Tulio de
dc.subject.por.fl_str_mv insomnia disorder
objective short sleep duration
hypothalamic-pituitary-adrenal axis
topic insomnia disorder
objective short sleep duration
hypothalamic-pituitary-adrenal axis
description Objective To evaluate the association between objective short sleep duration in patients with insomnia and changes in blood parameters related to hypothalamic-pituitary-adrenal (HPA) axis activity.Method A cross-sectional pilot study was conducted in 30 middle-aged adults with chronic insomnia who were divided into 2 groups according to polysomnography (PSG) total sleep time (TST) (TST > 5h and < 5h). All patients underwent subjective analysis of sleep quality, anthropometric measurements, PSG, and determination off asting blood parameters.Results The results revealed lower sleep efficiency and higher sleep latency for those with a TST < 5h. The subjective sleep quality was worse in the TST < 5h. Significantly, higher glucose and cortisol levels were observed with a TST < 5h. Glucose, cortisol and ACTH levels were inversely correlated with the PSG total sleep time.Conclusion Patients with insomnia with objective short sleep duration had HPA-associated endocrine and metabolic imbalances chronically linked to increases in cardiovascular risk observed with this more severe insomnia phenotype.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000600516
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000600516
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282X20150053
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.73 n.6 2015
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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