Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk

Detalhes bibliográficos
Autor(a) principal: Li,L. M.
Data de Publicação: 1996
Outros Autores: Russo,M., O'Donoghue,M. F., Duncan,J. S., Sander,J. W. A. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1996000100008
Resumo: Cutaneous rash is one of the commonest adverse events associated with lamotrigine. We assessed whether the risk is increased in patients receiving concomitant valproate therapy in a population of 103 adult patients with intractable epilepsy, who had lamotrigine added to their treatment. Of the 33 patients taking valproate, 10 (30%) developed a rash, whilst of the 70 not taking valproate, only 6 (8%) developed a rash. This suggests a significantly higher risk of cutaneous rash when starting lamotrigine in patients already taking valproate (p<0.02).
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spelling Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased riskallergic skin rashantiepileptic drugslamotriginevalproateCutaneous rash is one of the commonest adverse events associated with lamotrigine. We assessed whether the risk is increased in patients receiving concomitant valproate therapy in a population of 103 adult patients with intractable epilepsy, who had lamotrigine added to their treatment. Of the 33 patients taking valproate, 10 (30%) developed a rash, whilst of the 70 not taking valproate, only 6 (8%) developed a rash. This suggests a significantly higher risk of cutaneous rash when starting lamotrigine in patients already taking valproate (p<0.02).Academia Brasileira de Neurologia - ABNEURO1996-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1996000100008Arquivos de Neuro-Psiquiatria v.54 n.1 1996reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X1996000100008info:eu-repo/semantics/openAccessLi,L. M.Russo,M.O'Donoghue,M. F.Duncan,J. S.Sander,J. W. A. S.eng2010-12-07T00:00:00Zoai:scielo:S0004-282X1996000100008Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2010-12-07T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk
title Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk
spellingShingle Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk
Li,L. M.
allergic skin rash
antiepileptic drugs
lamotrigine
valproate
title_short Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk
title_full Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk
title_fullStr Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk
title_full_unstemmed Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk
title_sort Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk
author Li,L. M.
author_facet Li,L. M.
Russo,M.
O'Donoghue,M. F.
Duncan,J. S.
Sander,J. W. A. S.
author_role author
author2 Russo,M.
O'Donoghue,M. F.
Duncan,J. S.
Sander,J. W. A. S.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Li,L. M.
Russo,M.
O'Donoghue,M. F.
Duncan,J. S.
Sander,J. W. A. S.
dc.subject.por.fl_str_mv allergic skin rash
antiepileptic drugs
lamotrigine
valproate
topic allergic skin rash
antiepileptic drugs
lamotrigine
valproate
description Cutaneous rash is one of the commonest adverse events associated with lamotrigine. We assessed whether the risk is increased in patients receiving concomitant valproate therapy in a population of 103 adult patients with intractable epilepsy, who had lamotrigine added to their treatment. Of the 33 patients taking valproate, 10 (30%) developed a rash, whilst of the 70 not taking valproate, only 6 (8%) developed a rash. This suggests a significantly higher risk of cutaneous rash when starting lamotrigine in patients already taking valproate (p<0.02).
publishDate 1996
dc.date.none.fl_str_mv 1996-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1996000100008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1996000100008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X1996000100008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.54 n.1 1996
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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