Long-term safety of azathioprine for treatment of neuromyelitis optica spectrum disorders
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000300229 |
Resumo: | ABSTRACT Background: Azathioprine is a common first-line therapy for neuromyelitis optica spectrum disorder (NMOSD). Objective: The aim of this study was to determine whether long-term treatment (>10 years) with azathioprine is safe in NMOSD. Methods: We conducted a retrospective medical record review of all patients at the School of Medicine of the University of São Paulo (São Paulo, Brazil) who fulfilled the 2015 international consensus diagnostic criteria for NMOSD and were treated with azathioprine for at least 10 years. Results: Out of 375 patients assessed for eligibility, 19 were included in this analysis. These patients’ median age was 44 years (range=28-61); they were mostly female (17/19) and AQP4-IgG seropositive (18/19). The median disease duration was 15 years (range=10-39) and most patients presented a relapsing clinical course (84.2%). The median duration of treatment was 11.9 years (range=10.0-23.8). The median annualized relapse rates (ARR) pre- and post-treatment with azathioprine were 1 (range=0.1-2) and 0.1 (range=0-0.35); p=0.09. Three patients (15.7%) had records of adverse events during the follow-up, which consisted of chronic B12 vitamin deficiency, pulmonary tuberculosis and breast cancer. Conclusion: Azathioprine may be considered a safe agent for long-term treatment (>10 years) of NMOSD, but continuous vigilance for infections and malignancies is required. |
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Arquivos de neuro-psiquiatria (Online) |
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Long-term safety of azathioprine for treatment of neuromyelitis optica spectrum disordersAzathioprineNeuromyelitis OpticaTherapeuticsABSTRACT Background: Azathioprine is a common first-line therapy for neuromyelitis optica spectrum disorder (NMOSD). Objective: The aim of this study was to determine whether long-term treatment (>10 years) with azathioprine is safe in NMOSD. Methods: We conducted a retrospective medical record review of all patients at the School of Medicine of the University of São Paulo (São Paulo, Brazil) who fulfilled the 2015 international consensus diagnostic criteria for NMOSD and were treated with azathioprine for at least 10 years. Results: Out of 375 patients assessed for eligibility, 19 were included in this analysis. These patients’ median age was 44 years (range=28-61); they were mostly female (17/19) and AQP4-IgG seropositive (18/19). The median disease duration was 15 years (range=10-39) and most patients presented a relapsing clinical course (84.2%). The median duration of treatment was 11.9 years (range=10.0-23.8). The median annualized relapse rates (ARR) pre- and post-treatment with azathioprine were 1 (range=0.1-2) and 0.1 (range=0-0.35); p=0.09. Three patients (15.7%) had records of adverse events during the follow-up, which consisted of chronic B12 vitamin deficiency, pulmonary tuberculosis and breast cancer. Conclusion: Azathioprine may be considered a safe agent for long-term treatment (>10 years) of NMOSD, but continuous vigilance for infections and malignancies is required.Academia Brasileira de Neurologia - ABNEURO2021-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000300229Arquivos de Neuro-Psiquiatria v.79 n.3 2021reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x-anp-2020-0041info:eu-repo/semantics/openAccessGOMES,Ana Beatriz Ayroza Galvão RibeiroPITOMBEIRA,Milena SalesSATO,Douglas KazutoshiCALLEGARO,DagobertoAPÓSTOLOS-PEREIRA,Samira Luisaeng2021-04-15T00:00:00Zoai:scielo:S0004-282X2021000300229Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2021-04-15T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Long-term safety of azathioprine for treatment of neuromyelitis optica spectrum disorders |
title |
Long-term safety of azathioprine for treatment of neuromyelitis optica spectrum disorders |
spellingShingle |
Long-term safety of azathioprine for treatment of neuromyelitis optica spectrum disorders GOMES,Ana Beatriz Ayroza Galvão Ribeiro Azathioprine Neuromyelitis Optica Therapeutics |
title_short |
Long-term safety of azathioprine for treatment of neuromyelitis optica spectrum disorders |
title_full |
Long-term safety of azathioprine for treatment of neuromyelitis optica spectrum disorders |
title_fullStr |
Long-term safety of azathioprine for treatment of neuromyelitis optica spectrum disorders |
title_full_unstemmed |
Long-term safety of azathioprine for treatment of neuromyelitis optica spectrum disorders |
title_sort |
Long-term safety of azathioprine for treatment of neuromyelitis optica spectrum disorders |
author |
GOMES,Ana Beatriz Ayroza Galvão Ribeiro |
author_facet |
GOMES,Ana Beatriz Ayroza Galvão Ribeiro PITOMBEIRA,Milena Sales SATO,Douglas Kazutoshi CALLEGARO,Dagoberto APÓSTOLOS-PEREIRA,Samira Luisa |
author_role |
author |
author2 |
PITOMBEIRA,Milena Sales SATO,Douglas Kazutoshi CALLEGARO,Dagoberto APÓSTOLOS-PEREIRA,Samira Luisa |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
GOMES,Ana Beatriz Ayroza Galvão Ribeiro PITOMBEIRA,Milena Sales SATO,Douglas Kazutoshi CALLEGARO,Dagoberto APÓSTOLOS-PEREIRA,Samira Luisa |
dc.subject.por.fl_str_mv |
Azathioprine Neuromyelitis Optica Therapeutics |
topic |
Azathioprine Neuromyelitis Optica Therapeutics |
description |
ABSTRACT Background: Azathioprine is a common first-line therapy for neuromyelitis optica spectrum disorder (NMOSD). Objective: The aim of this study was to determine whether long-term treatment (>10 years) with azathioprine is safe in NMOSD. Methods: We conducted a retrospective medical record review of all patients at the School of Medicine of the University of São Paulo (São Paulo, Brazil) who fulfilled the 2015 international consensus diagnostic criteria for NMOSD and were treated with azathioprine for at least 10 years. Results: Out of 375 patients assessed for eligibility, 19 were included in this analysis. These patients’ median age was 44 years (range=28-61); they were mostly female (17/19) and AQP4-IgG seropositive (18/19). The median disease duration was 15 years (range=10-39) and most patients presented a relapsing clinical course (84.2%). The median duration of treatment was 11.9 years (range=10.0-23.8). The median annualized relapse rates (ARR) pre- and post-treatment with azathioprine were 1 (range=0.1-2) and 0.1 (range=0-0.35); p=0.09. Three patients (15.7%) had records of adverse events during the follow-up, which consisted of chronic B12 vitamin deficiency, pulmonary tuberculosis and breast cancer. Conclusion: Azathioprine may be considered a safe agent for long-term treatment (>10 years) of NMOSD, but continuous vigilance for infections and malignancies is required. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000300229 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000300229 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282x-anp-2020-0041 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.79 n.3 2021 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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