Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain

Detalhes bibliográficos
Autor(a) principal: ALVES,NILZA D.
Data de Publicação: 1999
Outros Autores: CASTRO-COSTA,CARLOS M. DE, CARVALHO,ALBA M. DE, SANTOS,FRANKLIN J. C., SILVEIRA,DELANO G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000600003
Resumo: Since anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action. For this, 41 Wistar rats were used, and in 25 of them a constrictive sciatic neuropathy was induced (Bennet & Xie model). For testing pain symptoms, spontaneous (scratching) and evoked behaviors to noxious (46o C) and non-noxious (40o C) thermal stimuli were quantified. Moreover, a comparative pharmacological study of vigabatrin with other analgesic anticonvulsant drugs was also performed. The results showed a possible dose-dependent analgesic effect of vigabatrin (gamma-vinyl-GABA) on experimental neuropathic pain, as shown by the significant (p<0.05) decreasing effect of vigabatrin on scratching and by its significant (p<0.05) increasing effect on the latency of the right hindpaw withdrawal of the animals to noxious thermal stimulus. This was corroborated by similar findings with analgesic anticonvulsants (carbamazepine, phenytoin and valproic acid). This possible and not yet described analgesic effect of vigabatrin seems not to be opioid mediated.
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spelling Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic painvigabatrinexperimentalneuropathic painscratching behaviorthermal testsWistar ratsanalgesiaSince anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action. For this, 41 Wistar rats were used, and in 25 of them a constrictive sciatic neuropathy was induced (Bennet & Xie model). For testing pain symptoms, spontaneous (scratching) and evoked behaviors to noxious (46o C) and non-noxious (40o C) thermal stimuli were quantified. Moreover, a comparative pharmacological study of vigabatrin with other analgesic anticonvulsant drugs was also performed. The results showed a possible dose-dependent analgesic effect of vigabatrin (gamma-vinyl-GABA) on experimental neuropathic pain, as shown by the significant (p<0.05) decreasing effect of vigabatrin on scratching and by its significant (p<0.05) increasing effect on the latency of the right hindpaw withdrawal of the animals to noxious thermal stimulus. This was corroborated by similar findings with analgesic anticonvulsants (carbamazepine, phenytoin and valproic acid). This possible and not yet described analgesic effect of vigabatrin seems not to be opioid mediated.Academia Brasileira de Neurologia - ABNEURO1999-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000600003Arquivos de Neuro-Psiquiatria v.57 n.4 1999reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X1999000600003info:eu-repo/semantics/openAccessALVES,NILZA D.CASTRO-COSTA,CARLOS M. DECARVALHO,ALBA M. DESANTOS,FRANKLIN J. C.SILVEIRA,DELANO G.eng2000-04-03T00:00:00Zoai:scielo:S0004-282X1999000600003Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2000-04-03T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain
title Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain
spellingShingle Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain
ALVES,NILZA D.
vigabatrin
experimental
neuropathic pain
scratching behavior
thermal tests
Wistar rats
analgesia
title_short Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain
title_full Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain
title_fullStr Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain
title_full_unstemmed Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain
title_sort Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain
author ALVES,NILZA D.
author_facet ALVES,NILZA D.
CASTRO-COSTA,CARLOS M. DE
CARVALHO,ALBA M. DE
SANTOS,FRANKLIN J. C.
SILVEIRA,DELANO G.
author_role author
author2 CASTRO-COSTA,CARLOS M. DE
CARVALHO,ALBA M. DE
SANTOS,FRANKLIN J. C.
SILVEIRA,DELANO G.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv ALVES,NILZA D.
CASTRO-COSTA,CARLOS M. DE
CARVALHO,ALBA M. DE
SANTOS,FRANKLIN J. C.
SILVEIRA,DELANO G.
dc.subject.por.fl_str_mv vigabatrin
experimental
neuropathic pain
scratching behavior
thermal tests
Wistar rats
analgesia
topic vigabatrin
experimental
neuropathic pain
scratching behavior
thermal tests
Wistar rats
analgesia
description Since anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action. For this, 41 Wistar rats were used, and in 25 of them a constrictive sciatic neuropathy was induced (Bennet & Xie model). For testing pain symptoms, spontaneous (scratching) and evoked behaviors to noxious (46o C) and non-noxious (40o C) thermal stimuli were quantified. Moreover, a comparative pharmacological study of vigabatrin with other analgesic anticonvulsant drugs was also performed. The results showed a possible dose-dependent analgesic effect of vigabatrin (gamma-vinyl-GABA) on experimental neuropathic pain, as shown by the significant (p<0.05) decreasing effect of vigabatrin on scratching and by its significant (p<0.05) increasing effect on the latency of the right hindpaw withdrawal of the animals to noxious thermal stimulus. This was corroborated by similar findings with analgesic anticonvulsants (carbamazepine, phenytoin and valproic acid). This possible and not yet described analgesic effect of vigabatrin seems not to be opioid mediated.
publishDate 1999
dc.date.none.fl_str_mv 1999-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000600003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000600003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X1999000600003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.57 n.4 1999
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
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reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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