Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain
Autor(a) principal: | |
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Data de Publicação: | 1999 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000600003 |
Resumo: | Since anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action. For this, 41 Wistar rats were used, and in 25 of them a constrictive sciatic neuropathy was induced (Bennet & Xie model). For testing pain symptoms, spontaneous (scratching) and evoked behaviors to noxious (46o C) and non-noxious (40o C) thermal stimuli were quantified. Moreover, a comparative pharmacological study of vigabatrin with other analgesic anticonvulsant drugs was also performed. The results showed a possible dose-dependent analgesic effect of vigabatrin (gamma-vinyl-GABA) on experimental neuropathic pain, as shown by the significant (p<0.05) decreasing effect of vigabatrin on scratching and by its significant (p<0.05) increasing effect on the latency of the right hindpaw withdrawal of the animals to noxious thermal stimulus. This was corroborated by similar findings with analgesic anticonvulsants (carbamazepine, phenytoin and valproic acid). This possible and not yet described analgesic effect of vigabatrin seems not to be opioid mediated. |
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Arquivos de neuro-psiquiatria (Online) |
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Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic painvigabatrinexperimentalneuropathic painscratching behaviorthermal testsWistar ratsanalgesiaSince anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action. For this, 41 Wistar rats were used, and in 25 of them a constrictive sciatic neuropathy was induced (Bennet & Xie model). For testing pain symptoms, spontaneous (scratching) and evoked behaviors to noxious (46o C) and non-noxious (40o C) thermal stimuli were quantified. Moreover, a comparative pharmacological study of vigabatrin with other analgesic anticonvulsant drugs was also performed. The results showed a possible dose-dependent analgesic effect of vigabatrin (gamma-vinyl-GABA) on experimental neuropathic pain, as shown by the significant (p<0.05) decreasing effect of vigabatrin on scratching and by its significant (p<0.05) increasing effect on the latency of the right hindpaw withdrawal of the animals to noxious thermal stimulus. This was corroborated by similar findings with analgesic anticonvulsants (carbamazepine, phenytoin and valproic acid). This possible and not yet described analgesic effect of vigabatrin seems not to be opioid mediated.Academia Brasileira de Neurologia - ABNEURO1999-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000600003Arquivos de Neuro-Psiquiatria v.57 n.4 1999reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X1999000600003info:eu-repo/semantics/openAccessALVES,NILZA D.CASTRO-COSTA,CARLOS M. DECARVALHO,ALBA M. DESANTOS,FRANKLIN J. C.SILVEIRA,DELANO G.eng2000-04-03T00:00:00Zoai:scielo:S0004-282X1999000600003Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2000-04-03T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain |
title |
Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain |
spellingShingle |
Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain ALVES,NILZA D. vigabatrin experimental neuropathic pain scratching behavior thermal tests Wistar rats analgesia |
title_short |
Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain |
title_full |
Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain |
title_fullStr |
Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain |
title_full_unstemmed |
Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain |
title_sort |
Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain |
author |
ALVES,NILZA D. |
author_facet |
ALVES,NILZA D. CASTRO-COSTA,CARLOS M. DE CARVALHO,ALBA M. DE SANTOS,FRANKLIN J. C. SILVEIRA,DELANO G. |
author_role |
author |
author2 |
CASTRO-COSTA,CARLOS M. DE CARVALHO,ALBA M. DE SANTOS,FRANKLIN J. C. SILVEIRA,DELANO G. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
ALVES,NILZA D. CASTRO-COSTA,CARLOS M. DE CARVALHO,ALBA M. DE SANTOS,FRANKLIN J. C. SILVEIRA,DELANO G. |
dc.subject.por.fl_str_mv |
vigabatrin experimental neuropathic pain scratching behavior thermal tests Wistar rats analgesia |
topic |
vigabatrin experimental neuropathic pain scratching behavior thermal tests Wistar rats analgesia |
description |
Since anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action. For this, 41 Wistar rats were used, and in 25 of them a constrictive sciatic neuropathy was induced (Bennet & Xie model). For testing pain symptoms, spontaneous (scratching) and evoked behaviors to noxious (46o C) and non-noxious (40o C) thermal stimuli were quantified. Moreover, a comparative pharmacological study of vigabatrin with other analgesic anticonvulsant drugs was also performed. The results showed a possible dose-dependent analgesic effect of vigabatrin (gamma-vinyl-GABA) on experimental neuropathic pain, as shown by the significant (p<0.05) decreasing effect of vigabatrin on scratching and by its significant (p<0.05) increasing effect on the latency of the right hindpaw withdrawal of the animals to noxious thermal stimulus. This was corroborated by similar findings with analgesic anticonvulsants (carbamazepine, phenytoin and valproic acid). This possible and not yet described analgesic effect of vigabatrin seems not to be opioid mediated. |
publishDate |
1999 |
dc.date.none.fl_str_mv |
1999-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000600003 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000600003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X1999000600003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.57 n.4 1999 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212751965683712 |