Genetic variants related to angiogenesis and apoptosis in patients with glioma
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000600393 |
Resumo: | ABSTRACT Background Glioma, the most common primary malignant brain tumor in adults, is highly aggressive and associated with a poor prognosis. The objectives of this study were to evaluate the association of genetic polymorphisms related to angiogenesis and apoptosis with gliomas, as well as comorbidities, lifestyle, clinical profile, survival and response to treatment (temozolomide [TMZ] and radiotherapy [RT]) in patients with the disease. Methods In a total of 303 individuals, genotypes were performed by real-time PCR, and clinical data, lifestyle and comorbidities were obtained from medical records and questionnaires. The significance level was set at 5%. Results Smoking, alcohol consumption, systemic arterial hypertension, diabetes mellitus and body mass index prevailed among patients, compared to controls (p < 0.05). The heterozygous genotype rs1468727 (T/C) and the homozygous genotype rs2010963 (G/G) (p > 0.05) were observed in both groups. Lifestyle and comorbidities showed independent risk factors for the disease (p < 0.0001, p = 0.0069, p = 0.0394, respectively). Patients with low-grade gliomas had a survival rate of 80.0 ± 1.7% in three years. For the combination of TMZ+RT, survival was 78.7 ± 7.6% in 20 months, compared to TMZ only (21.9 ± 5.1%, p = 0.8711). Conclusions Genetic variants were not associated with gliomas. Specific lifestyle habits and comorbidities stood out as independent risk factors for the disease. Low-grade gliomas showed an increase in patient survival with TMZ+RT treatment. |
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Genetic variants related to angiogenesis and apoptosis in patients with gliomacentral nervous systemgenes, erbB-1glioblastomaABSTRACT Background Glioma, the most common primary malignant brain tumor in adults, is highly aggressive and associated with a poor prognosis. The objectives of this study were to evaluate the association of genetic polymorphisms related to angiogenesis and apoptosis with gliomas, as well as comorbidities, lifestyle, clinical profile, survival and response to treatment (temozolomide [TMZ] and radiotherapy [RT]) in patients with the disease. Methods In a total of 303 individuals, genotypes were performed by real-time PCR, and clinical data, lifestyle and comorbidities were obtained from medical records and questionnaires. The significance level was set at 5%. Results Smoking, alcohol consumption, systemic arterial hypertension, diabetes mellitus and body mass index prevailed among patients, compared to controls (p < 0.05). The heterozygous genotype rs1468727 (T/C) and the homozygous genotype rs2010963 (G/G) (p > 0.05) were observed in both groups. Lifestyle and comorbidities showed independent risk factors for the disease (p < 0.0001, p = 0.0069, p = 0.0394, respectively). Patients with low-grade gliomas had a survival rate of 80.0 ± 1.7% in three years. For the combination of TMZ+RT, survival was 78.7 ± 7.6% in 20 months, compared to TMZ only (21.9 ± 5.1%, p = 0.8711). Conclusions Genetic variants were not associated with gliomas. Specific lifestyle habits and comorbidities stood out as independent risk factors for the disease. Low-grade gliomas showed an increase in patient survival with TMZ+RT treatment.Academia Brasileira de Neurologia - ABNEURO2018-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000600393Arquivos de Neuro-Psiquiatria v.76 n.6 2018reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20180051info:eu-repo/semantics/openAccessCalastri,Maria Clara JessicaRodrigues,Nicolas Luz Toledo OrtegaHatori,GabrielaGregório,Michele LimaBrancati,Camila Ive Ferreira OliveiraZanovelo,Eliane MilharcixFerraz Filho,José Roberto LopesNeiva,Cassiano MerussiRodrigues Junior,Antonio Carlos PondeGodoy,Moacir Fernandes deLancelloti,Carmen Lucia PenteadoTognola,Waldir AntonioSouza,Dorotéia Rossi Silvaeng2018-06-26T00:00:00Zoai:scielo:S0004-282X2018000600393Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2018-06-26T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Genetic variants related to angiogenesis and apoptosis in patients with glioma |
title |
Genetic variants related to angiogenesis and apoptosis in patients with glioma |
spellingShingle |
Genetic variants related to angiogenesis and apoptosis in patients with glioma Calastri,Maria Clara Jessica central nervous system genes, erbB-1 glioblastoma |
title_short |
Genetic variants related to angiogenesis and apoptosis in patients with glioma |
title_full |
Genetic variants related to angiogenesis and apoptosis in patients with glioma |
title_fullStr |
Genetic variants related to angiogenesis and apoptosis in patients with glioma |
title_full_unstemmed |
Genetic variants related to angiogenesis and apoptosis in patients with glioma |
title_sort |
Genetic variants related to angiogenesis and apoptosis in patients with glioma |
author |
Calastri,Maria Clara Jessica |
author_facet |
Calastri,Maria Clara Jessica Rodrigues,Nicolas Luz Toledo Ortega Hatori,Gabriela Gregório,Michele Lima Brancati,Camila Ive Ferreira Oliveira Zanovelo,Eliane Milharcix Ferraz Filho,José Roberto Lopes Neiva,Cassiano Merussi Rodrigues Junior,Antonio Carlos Ponde Godoy,Moacir Fernandes de Lancelloti,Carmen Lucia Penteado Tognola,Waldir Antonio Souza,Dorotéia Rossi Silva |
author_role |
author |
author2 |
Rodrigues,Nicolas Luz Toledo Ortega Hatori,Gabriela Gregório,Michele Lima Brancati,Camila Ive Ferreira Oliveira Zanovelo,Eliane Milharcix Ferraz Filho,José Roberto Lopes Neiva,Cassiano Merussi Rodrigues Junior,Antonio Carlos Ponde Godoy,Moacir Fernandes de Lancelloti,Carmen Lucia Penteado Tognola,Waldir Antonio Souza,Dorotéia Rossi Silva |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Calastri,Maria Clara Jessica Rodrigues,Nicolas Luz Toledo Ortega Hatori,Gabriela Gregório,Michele Lima Brancati,Camila Ive Ferreira Oliveira Zanovelo,Eliane Milharcix Ferraz Filho,José Roberto Lopes Neiva,Cassiano Merussi Rodrigues Junior,Antonio Carlos Ponde Godoy,Moacir Fernandes de Lancelloti,Carmen Lucia Penteado Tognola,Waldir Antonio Souza,Dorotéia Rossi Silva |
dc.subject.por.fl_str_mv |
central nervous system genes, erbB-1 glioblastoma |
topic |
central nervous system genes, erbB-1 glioblastoma |
description |
ABSTRACT Background Glioma, the most common primary malignant brain tumor in adults, is highly aggressive and associated with a poor prognosis. The objectives of this study were to evaluate the association of genetic polymorphisms related to angiogenesis and apoptosis with gliomas, as well as comorbidities, lifestyle, clinical profile, survival and response to treatment (temozolomide [TMZ] and radiotherapy [RT]) in patients with the disease. Methods In a total of 303 individuals, genotypes were performed by real-time PCR, and clinical data, lifestyle and comorbidities were obtained from medical records and questionnaires. The significance level was set at 5%. Results Smoking, alcohol consumption, systemic arterial hypertension, diabetes mellitus and body mass index prevailed among patients, compared to controls (p < 0.05). The heterozygous genotype rs1468727 (T/C) and the homozygous genotype rs2010963 (G/G) (p > 0.05) were observed in both groups. Lifestyle and comorbidities showed independent risk factors for the disease (p < 0.0001, p = 0.0069, p = 0.0394, respectively). Patients with low-grade gliomas had a survival rate of 80.0 ± 1.7% in three years. For the combination of TMZ+RT, survival was 78.7 ± 7.6% in 20 months, compared to TMZ only (21.9 ± 5.1%, p = 0.8711). Conclusions Genetic variants were not associated with gliomas. Specific lifestyle habits and comorbidities stood out as independent risk factors for the disease. Low-grade gliomas showed an increase in patient survival with TMZ+RT treatment. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000600393 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000600393 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282x20180051 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.76 n.6 2018 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
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