Real-world experience of ocrelizumab in multiple sclerosis patients in Latin America
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000400305 |
Resumo: | ABSTRACT Background: Despite the abundance of information concerning ocrelizumab in phase III clinical trials, there is scarce evidence regarding real-world patient profiles. Objective: The aim of this study was to investigate patient profiles, effectiveness and persistence with treatment among patients who used ocrelizumab for treatment of multiple sclerosis in Latin America. Methods: This was a retrospective multicenter study in Argentina, Chile and Mexico. Medical record databases on patients who received ocrelizumab were analyzed. Demographic and clinical variables were described, along with effectiveness outcomes, which included the proportions of patients free from clinical relapses, from disability progression and from new or enlarging T2 or T1 gadolinium-enhancing lesions, on annual magnetic resonance imaging. Results: A total of 81 patients were included. The most frequent phenotype was relapsing-remitting MS, in 64.2% of the patients. The mean age at study entry was 41.3 ± 12.0 years and 51.8% were women. A total of 38% had had relapse activity during the 12 months before starting on ocrelizumab, with a mean relapse rate of 1.3 ± 0.6 during that period. 75% were free from clinical relapses and 91% were free from gadolinium-enhancing lesions in the relapsing-remitting course. Ocrelizumab discontinuation during the first 12 months was observed in three patients (3.7%). The mean persistence observed during the first-year follow-up was 338 ± 24 days. Conclusions: Our study is in line with previous randomized clinical trials and recent real-world studies describing patient profiles, effectiveness and persistence regarding ocrelizumab treatment in multiple sclerosis patients in Latin America. |
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Arquivos de neuro-psiquiatria (Online) |
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Real-world experience of ocrelizumab in multiple sclerosis patients in Latin AmericaMultiple SclerosisPharmaceutical PreparationsLatin AmericaEffective LifeABSTRACT Background: Despite the abundance of information concerning ocrelizumab in phase III clinical trials, there is scarce evidence regarding real-world patient profiles. Objective: The aim of this study was to investigate patient profiles, effectiveness and persistence with treatment among patients who used ocrelizumab for treatment of multiple sclerosis in Latin America. Methods: This was a retrospective multicenter study in Argentina, Chile and Mexico. Medical record databases on patients who received ocrelizumab were analyzed. Demographic and clinical variables were described, along with effectiveness outcomes, which included the proportions of patients free from clinical relapses, from disability progression and from new or enlarging T2 or T1 gadolinium-enhancing lesions, on annual magnetic resonance imaging. Results: A total of 81 patients were included. The most frequent phenotype was relapsing-remitting MS, in 64.2% of the patients. The mean age at study entry was 41.3 ± 12.0 years and 51.8% were women. A total of 38% had had relapse activity during the 12 months before starting on ocrelizumab, with a mean relapse rate of 1.3 ± 0.6 during that period. 75% were free from clinical relapses and 91% were free from gadolinium-enhancing lesions in the relapsing-remitting course. Ocrelizumab discontinuation during the first 12 months was observed in three patients (3.7%). The mean persistence observed during the first-year follow-up was 338 ± 24 days. Conclusions: Our study is in line with previous randomized clinical trials and recent real-world studies describing patient profiles, effectiveness and persistence regarding ocrelizumab treatment in multiple sclerosis patients in Latin America.Academia Brasileira de Neurologia - ABNEURO2021-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000400305Arquivos de Neuro-Psiquiatria v.79 n.4 2021reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x-anp-2020-0339info:eu-repo/semantics/openAccessROJAS,Juan IgnacioPATRUCCO,LilianaFRUNS,ManuelHORNUNG,GieselaFLORES,JoséCARNERO CONTENTTI,EdgarLOPEZ,Pablo AdrianPETTINICCHI,Juan PabloCARIDE,AlejandroGALLEGUILLOS,LornaBARAHONA,JorgeDIAZ,VioletaHERNÁNDEZ,MarianellaALONSO,RicardoCRISTIANO,Edgardoeng2021-06-07T00:00:00Zoai:scielo:S0004-282X2021000400305Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2021-06-07T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Real-world experience of ocrelizumab in multiple sclerosis patients in Latin America |
title |
Real-world experience of ocrelizumab in multiple sclerosis patients in Latin America |
spellingShingle |
Real-world experience of ocrelizumab in multiple sclerosis patients in Latin America ROJAS,Juan Ignacio Multiple Sclerosis Pharmaceutical Preparations Latin America Effective Life |
title_short |
Real-world experience of ocrelizumab in multiple sclerosis patients in Latin America |
title_full |
Real-world experience of ocrelizumab in multiple sclerosis patients in Latin America |
title_fullStr |
Real-world experience of ocrelizumab in multiple sclerosis patients in Latin America |
title_full_unstemmed |
Real-world experience of ocrelizumab in multiple sclerosis patients in Latin America |
title_sort |
Real-world experience of ocrelizumab in multiple sclerosis patients in Latin America |
author |
ROJAS,Juan Ignacio |
author_facet |
ROJAS,Juan Ignacio PATRUCCO,Liliana FRUNS,Manuel HORNUNG,Giesela FLORES,José CARNERO CONTENTTI,Edgar LOPEZ,Pablo Adrian PETTINICCHI,Juan Pablo CARIDE,Alejandro GALLEGUILLOS,Lorna BARAHONA,Jorge DIAZ,Violeta HERNÁNDEZ,Marianella ALONSO,Ricardo CRISTIANO,Edgardo |
author_role |
author |
author2 |
PATRUCCO,Liliana FRUNS,Manuel HORNUNG,Giesela FLORES,José CARNERO CONTENTTI,Edgar LOPEZ,Pablo Adrian PETTINICCHI,Juan Pablo CARIDE,Alejandro GALLEGUILLOS,Lorna BARAHONA,Jorge DIAZ,Violeta HERNÁNDEZ,Marianella ALONSO,Ricardo CRISTIANO,Edgardo |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
ROJAS,Juan Ignacio PATRUCCO,Liliana FRUNS,Manuel HORNUNG,Giesela FLORES,José CARNERO CONTENTTI,Edgar LOPEZ,Pablo Adrian PETTINICCHI,Juan Pablo CARIDE,Alejandro GALLEGUILLOS,Lorna BARAHONA,Jorge DIAZ,Violeta HERNÁNDEZ,Marianella ALONSO,Ricardo CRISTIANO,Edgardo |
dc.subject.por.fl_str_mv |
Multiple Sclerosis Pharmaceutical Preparations Latin America Effective Life |
topic |
Multiple Sclerosis Pharmaceutical Preparations Latin America Effective Life |
description |
ABSTRACT Background: Despite the abundance of information concerning ocrelizumab in phase III clinical trials, there is scarce evidence regarding real-world patient profiles. Objective: The aim of this study was to investigate patient profiles, effectiveness and persistence with treatment among patients who used ocrelizumab for treatment of multiple sclerosis in Latin America. Methods: This was a retrospective multicenter study in Argentina, Chile and Mexico. Medical record databases on patients who received ocrelizumab were analyzed. Demographic and clinical variables were described, along with effectiveness outcomes, which included the proportions of patients free from clinical relapses, from disability progression and from new or enlarging T2 or T1 gadolinium-enhancing lesions, on annual magnetic resonance imaging. Results: A total of 81 patients were included. The most frequent phenotype was relapsing-remitting MS, in 64.2% of the patients. The mean age at study entry was 41.3 ± 12.0 years and 51.8% were women. A total of 38% had had relapse activity during the 12 months before starting on ocrelizumab, with a mean relapse rate of 1.3 ± 0.6 during that period. 75% were free from clinical relapses and 91% were free from gadolinium-enhancing lesions in the relapsing-remitting course. Ocrelizumab discontinuation during the first 12 months was observed in three patients (3.7%). The mean persistence observed during the first-year follow-up was 338 ± 24 days. Conclusions: Our study is in line with previous randomized clinical trials and recent real-world studies describing patient profiles, effectiveness and persistence regarding ocrelizumab treatment in multiple sclerosis patients in Latin America. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000400305 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000400305 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282x-anp-2020-0339 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.79 n.4 2021 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212788415234048 |