Clinical and Histopathological Evaluation of Photodynamic Therapy Associated with The Low-Level Laser Therapy on Patients with Actinic Cheilitis - A Six-Month Follow-Up Trial
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Odontologia |
Texto Completo: | https://revista.aborj.org.br/index.php/rbo/article/view/1861 |
Resumo: | Objective: the aim of the present study was to evaluate the clinical and histopathological efficacy of photodynamic therapy (PDT) associated with the low-level laser therapy (LLLT) in the treatment of patients with Actinic Cheilitis (AC) after a six-month follow-up. Material and Methods: patients with active AC undergone through two sessions of PDT, associated with the low-level laser therapy using the Methyl 5-aminolevulinate as a photosensybilizer drug. After a six-month follow-up, a new incisional biopsy was performed in order to evaluate the response to treatment. Results: excellent efficacy rates were observed in the improvement of symptoms in this study, however, histopathological analysis was not so promising and the improvement of dysplasia degree could only be seen in 20% of the sample. Conclusion: according to the results of the present study, we concluded that the photodynamic therapy associated with low-level laser therapy is an option to be considered when treating Actinic Cheilits. However, patients should be clinically followed-up in a severing agenda and eventually, histopathologically |
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Clinical and Histopathological Evaluation of Photodynamic Therapy Associated with The Low-Level Laser Therapy on Patients with Actinic Cheilitis - A Six-Month Follow-Up TrialAvaliação clínica e histopatológica da eficácia do tratamento utilizando terapia fotodinâmica associada ao laser de baixa potência em pacientes portadores de queilite actínica - Um acompanhamento de 6 mesesDENTAL MEDICINE (DENTISTRY)Actinic chellits; Photochemotherapy; Low-level light therapy; BiopsyMEDICINA DENTÁRIA (ODONTOLOGIA)Queilite Actínica; Fotoquimioterapia; Laserterapia de baixa potência; BiópsiaObjective: the aim of the present study was to evaluate the clinical and histopathological efficacy of photodynamic therapy (PDT) associated with the low-level laser therapy (LLLT) in the treatment of patients with Actinic Cheilitis (AC) after a six-month follow-up. Material and Methods: patients with active AC undergone through two sessions of PDT, associated with the low-level laser therapy using the Methyl 5-aminolevulinate as a photosensybilizer drug. After a six-month follow-up, a new incisional biopsy was performed in order to evaluate the response to treatment. Results: excellent efficacy rates were observed in the improvement of symptoms in this study, however, histopathological analysis was not so promising and the improvement of dysplasia degree could only be seen in 20% of the sample. Conclusion: according to the results of the present study, we concluded that the photodynamic therapy associated with low-level laser therapy is an option to be considered when treating Actinic Cheilits. However, patients should be clinically followed-up in a severing agenda and eventually, histopathologicallyO objetivo do presente estudo foi avaliar a eficácia clínica e histopatológica da terapia fotodinâmica (TFD) associada à terapia a laser de baixa potência no tratamento de pacientes com queilite actínica (QA) após seis meses de acompanhamento. Material e Métodos: pacientes com QA ativa foram submetidos a duas sessões de TFD associadas à laserterapia de baixa potência, utilizando o 5-aminolevulinato de metila como droga fotossensibilizadora. Após seis meses de acompanhamento, uma nova biópsia incisional foi realizada para avaliar a resposta ao tratamento. Resultados: excelentes taxas de eficácia foram observadas na melhora dos sintomas neste estudo, no entanto, a análise histopatológica não foi tão promissora e apenas a melhora do grau de displasia só pode ser observada em 20% da amostra. Conclusão: de acordo com os resultados do presente estudo, pode-se concluir que a terapia fotodinâmica associada à laserterapia de baixa potência parece ser uma opção a ser considerada no tratamento da Queilite Actínica. No entanto, os pacientes devem ser acompanhados de perto clinicamente e, eventualmente, histopatologicamenteAssociação Brasileira de Odontologia - Seção Rio de JaneiroBNDESFINEPNational Institute of Optics and Photonics - INCT programCePOFFAPESPOral Pathology Lab of the State University of Rio de JaneiroBNDESFINEPInstituto Nacional de Ótica e Fotônica - programa INCTCePOFFAPESPLaboratório de Patologia Oral da Universidade Estadual do Rio de JaneiroRodrigues, Bruno Teixeira GonçalvesEspaña, Manuella Braun de Oliveiradas Chagas, Wagner PintoFreire, Nathália de AlmeidaBuzzá, Hilde HarbIsrael, Mônica Simões2020-07-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revista.aborj.org.br/index.php/rbo/article/view/186110.18363/rbo.v77.2020.e1861Revista Brasileira de Odontologia; v. 77 (2020); 1/6Revista Brasileira de Odontologia; v. 77 (2020); 1/61984-3747reponame:Revista Brasileira de Odontologiainstname:Associação Brasileira de Odontologia (ABO)instacron:ABOenghttps://revista.aborj.org.br/index.php/rbo/article/view/1861/pdfhttps://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1861/2191https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1861/2192Rio de Janeiro; Brazil; Latin AmericaRio de Janeiro; Brasil; América LatinaDireitos autorais 2020 Rev. Bras. Odontol.http://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess2020-12-23T17:40:46Zoai:revista_aborj_org_br.www.revista.aborj.org.br:article/1861Revistahttps://revista.aborj.org.br/index.php/rboONGhttp://www.revista.aborj.org.br/index.php/rbo/oaihttps://revista.aborj.org.br/index.php/rbo/oai0034-72721984-3747opendoar:2020-12-23T17:40:46Revista Brasileira de Odontologia - Associação Brasileira de Odontologia (ABO)false |
dc.title.none.fl_str_mv |
Clinical and Histopathological Evaluation of Photodynamic Therapy Associated with The Low-Level Laser Therapy on Patients with Actinic Cheilitis - A Six-Month Follow-Up Trial Avaliação clínica e histopatológica da eficácia do tratamento utilizando terapia fotodinâmica associada ao laser de baixa potência em pacientes portadores de queilite actínica - Um acompanhamento de 6 meses |
title |
Clinical and Histopathological Evaluation of Photodynamic Therapy Associated with The Low-Level Laser Therapy on Patients with Actinic Cheilitis - A Six-Month Follow-Up Trial |
spellingShingle |
Clinical and Histopathological Evaluation of Photodynamic Therapy Associated with The Low-Level Laser Therapy on Patients with Actinic Cheilitis - A Six-Month Follow-Up Trial Rodrigues, Bruno Teixeira Gonçalves DENTAL MEDICINE (DENTISTRY) Actinic chellits; Photochemotherapy; Low-level light therapy; Biopsy MEDICINA DENTÁRIA (ODONTOLOGIA) Queilite Actínica; Fotoquimioterapia; Laserterapia de baixa potência; Biópsia |
title_short |
Clinical and Histopathological Evaluation of Photodynamic Therapy Associated with The Low-Level Laser Therapy on Patients with Actinic Cheilitis - A Six-Month Follow-Up Trial |
title_full |
Clinical and Histopathological Evaluation of Photodynamic Therapy Associated with The Low-Level Laser Therapy on Patients with Actinic Cheilitis - A Six-Month Follow-Up Trial |
title_fullStr |
Clinical and Histopathological Evaluation of Photodynamic Therapy Associated with The Low-Level Laser Therapy on Patients with Actinic Cheilitis - A Six-Month Follow-Up Trial |
title_full_unstemmed |
Clinical and Histopathological Evaluation of Photodynamic Therapy Associated with The Low-Level Laser Therapy on Patients with Actinic Cheilitis - A Six-Month Follow-Up Trial |
title_sort |
Clinical and Histopathological Evaluation of Photodynamic Therapy Associated with The Low-Level Laser Therapy on Patients with Actinic Cheilitis - A Six-Month Follow-Up Trial |
author |
Rodrigues, Bruno Teixeira Gonçalves |
author_facet |
Rodrigues, Bruno Teixeira Gonçalves España, Manuella Braun de Oliveira das Chagas, Wagner Pinto Freire, Nathália de Almeida Buzzá, Hilde Harb Israel, Mônica Simões |
author_role |
author |
author2 |
España, Manuella Braun de Oliveira das Chagas, Wagner Pinto Freire, Nathália de Almeida Buzzá, Hilde Harb Israel, Mônica Simões |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
BNDES FINEP National Institute of Optics and Photonics - INCT program CePOF FAPESP Oral Pathology Lab of the State University of Rio de Janeiro BNDES FINEP Instituto Nacional de Ótica e Fotônica - programa INCT CePOF FAPESP Laboratório de Patologia Oral da Universidade Estadual do Rio de Janeiro |
dc.contributor.author.fl_str_mv |
Rodrigues, Bruno Teixeira Gonçalves España, Manuella Braun de Oliveira das Chagas, Wagner Pinto Freire, Nathália de Almeida Buzzá, Hilde Harb Israel, Mônica Simões |
dc.subject.none.fl_str_mv |
|
dc.subject.por.fl_str_mv |
DENTAL MEDICINE (DENTISTRY) Actinic chellits; Photochemotherapy; Low-level light therapy; Biopsy MEDICINA DENTÁRIA (ODONTOLOGIA) Queilite Actínica; Fotoquimioterapia; Laserterapia de baixa potência; Biópsia |
topic |
DENTAL MEDICINE (DENTISTRY) Actinic chellits; Photochemotherapy; Low-level light therapy; Biopsy MEDICINA DENTÁRIA (ODONTOLOGIA) Queilite Actínica; Fotoquimioterapia; Laserterapia de baixa potência; Biópsia |
description |
Objective: the aim of the present study was to evaluate the clinical and histopathological efficacy of photodynamic therapy (PDT) associated with the low-level laser therapy (LLLT) in the treatment of patients with Actinic Cheilitis (AC) after a six-month follow-up. Material and Methods: patients with active AC undergone through two sessions of PDT, associated with the low-level laser therapy using the Methyl 5-aminolevulinate as a photosensybilizer drug. After a six-month follow-up, a new incisional biopsy was performed in order to evaluate the response to treatment. Results: excellent efficacy rates were observed in the improvement of symptoms in this study, however, histopathological analysis was not so promising and the improvement of dysplasia degree could only be seen in 20% of the sample. Conclusion: according to the results of the present study, we concluded that the photodynamic therapy associated with low-level laser therapy is an option to be considered when treating Actinic Cheilits. However, patients should be clinically followed-up in a severing agenda and eventually, histopathologically |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-07-15 |
dc.type.none.fl_str_mv |
|
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revista.aborj.org.br/index.php/rbo/article/view/1861 10.18363/rbo.v77.2020.e1861 |
url |
https://revista.aborj.org.br/index.php/rbo/article/view/1861 |
identifier_str_mv |
10.18363/rbo.v77.2020.e1861 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revista.aborj.org.br/index.php/rbo/article/view/1861/pdf https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1861/2191 https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1861/2192 |
dc.rights.driver.fl_str_mv |
Direitos autorais 2020 Rev. Bras. Odontol. http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Direitos autorais 2020 Rev. Bras. Odontol. http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
Rio de Janeiro; Brazil; Latin America Rio de Janeiro; Brasil; América Latina |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Odontologia - Seção Rio de Janeiro |
publisher.none.fl_str_mv |
Associação Brasileira de Odontologia - Seção Rio de Janeiro |
dc.source.none.fl_str_mv |
Revista Brasileira de Odontologia; v. 77 (2020); 1/6 Revista Brasileira de Odontologia; v. 77 (2020); 1/6 1984-3747 reponame:Revista Brasileira de Odontologia instname:Associação Brasileira de Odontologia (ABO) instacron:ABO |
instname_str |
Associação Brasileira de Odontologia (ABO) |
instacron_str |
ABO |
institution |
ABO |
reponame_str |
Revista Brasileira de Odontologia |
collection |
Revista Brasileira de Odontologia |
repository.name.fl_str_mv |
Revista Brasileira de Odontologia - Associação Brasileira de Odontologia (ABO) |
repository.mail.fl_str_mv |
https://revista.aborj.org.br/index.php/rbo/oai |
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1798313202680856576 |