Analysis of drug interactions in dental prescriptions.
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Odontologia |
Texto Completo: | https://revista.aborj.org.br/index.php/rbo/article/view/1021 |
Resumo: | Objective: to evaluate the potential drug interactions (DI) in prescriptions for patients of a private university’s dental clinic. Material and Methods: this is an exploratory descriptive study. A total of 204 dental prescriptions were analyzed between April 2015 and October 2016. The databases for the analysis of DI potential wereaccessed through the programs Medscape, Drugs.com and Micromedex.The DIs were classified by intensity in major, moderate and minor. Results: the mean age was 43 ± 14 years old and 61% of the participants were female. Hypertension and Type II diabetes were the most prevalent diseases. 237 non-steroidal anti-inflammatory drugs were prescribed, with nimesulide being the most prevalent in the prescriptions, followed by dipyrone with analgesic and antipyretic effect. Of these, eighty-nine were antimicrobials, mostly amoxicillin. We identified 95 potential drug interactions, 28% being of major intensity and 67% of moderate intensity. Twelve interactions involved non-steroidal anti-inflammatory drugs, mainly ketoprofen, diclofenac and ibuprofen; and nine were related to the antimicrobials amoxicillin, metronizadol and azithromycin. Conclusion: The need for a careful analysis of dental prescriptions and a review of the concomitant therapy used by patients, reducing the risk of interactions, and consequently, preventing adverse reactions and preserving the patients’ safety, are observed. |
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Analysis of drug interactions in dental prescriptions.Análise de interações medicamentosas em prescrições dentáriasPHARMACOLOGYDrug Interactions; Dentistry; Non-steroidal anti-inflammatory drugs; Anti-Infectious.MEDICINA DENTÁRIA (ODONTOLOGIA)Interações medicamentosas; Odontologia; Anti-inflamatórios não esteróides; Anti-infecciosoObjective: to evaluate the potential drug interactions (DI) in prescriptions for patients of a private university’s dental clinic. Material and Methods: this is an exploratory descriptive study. A total of 204 dental prescriptions were analyzed between April 2015 and October 2016. The databases for the analysis of DI potential wereaccessed through the programs Medscape, Drugs.com and Micromedex.The DIs were classified by intensity in major, moderate and minor. Results: the mean age was 43 ± 14 years old and 61% of the participants were female. Hypertension and Type II diabetes were the most prevalent diseases. 237 non-steroidal anti-inflammatory drugs were prescribed, with nimesulide being the most prevalent in the prescriptions, followed by dipyrone with analgesic and antipyretic effect. Of these, eighty-nine were antimicrobials, mostly amoxicillin. We identified 95 potential drug interactions, 28% being of major intensity and 67% of moderate intensity. Twelve interactions involved non-steroidal anti-inflammatory drugs, mainly ketoprofen, diclofenac and ibuprofen; and nine were related to the antimicrobials amoxicillin, metronizadol and azithromycin. Conclusion: The need for a careful analysis of dental prescriptions and a review of the concomitant therapy used by patients, reducing the risk of interactions, and consequently, preventing adverse reactions and preserving the patients’ safety, are observed.Objetivo: avaliar as interações medicamentosas potenciais (DI) em prescrições para pacientes de clínica odontológica de uma universidade privada. Material e Métodos: trata-se de um estudo exploratório descritivo. Foram analisadas 204 prescrições odontológicas entre abril de 2015 e outubro de 2016. As bases de dados para a análise do potencial de DI foram acessadas pelos programas Medscape, Drugs.com e Micromedex. Os DIs foram classificados por intensidade em maior, moderada e menor. Resultados: a média de idade foi de 43 ± 14 anos e 61% dos participantes eram do sexo feminino. Hipertensão e diabetes tipo II foram as doenças mais prevalentes. 237 anti-inflamatórios não esteroidais foram prescritos, sendo a nimesulida a mais prevalente nas prescrições, seguida da dipirona com efeito analgésico e antipirético. Destes, oitenta e nove eram antimicrobianos, principalmente amoxicilina. Foram identificadas 95 interações medicamentosas potenciais, sendo 28% de maior intensidade e 67% de intensidade moderada. Doze interações envolveram drogas antiinflamatórias não esteroidais, principalmente cetoprofeno, diclofenaco e ibuprofeno; e nove foram relacionados aos antimicrobianos amoxicilina, metronizadol e azitromicina. Conclusão: A necessidade de uma análise cuidadosa das prescrições dentárias e uma revisão da terapia concomitante utilizada pelos pacientes, reduzindo o risco de interações e, conseqüentemente, prevenindo reações adversas e preservando a segurança dos pacientes, são observadas.Associação Brasileira de Odontologia - Seção Rio de JaneiroFurini, Adriana Antônia da CruzMalagoli, Juliana Mendes de AlmeidaDias, Nayane JustiLima, Bruna MirandaBonjardin, Manuela ManzanoMachado, Ponatyellen SouzaLima, Tiago Aparecido Maschio de2018-07-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionOriginal ArticleArtigo Originalapplication/pdfhttps://revista.aborj.org.br/index.php/rbo/article/view/102110.18363/rbo.v75.2018.e1021Revista Brasileira de Odontologia; v. 75 (2018); 1/6Revista Brasileira de Odontologia; v. 75 (2018); 1/61984-3747reponame:Revista Brasileira de Odontologiainstname:Associação Brasileira de Odontologia (ABO)instacron:ABOenghttps://revista.aborj.org.br/index.php/rbo/article/view/1021/682https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1021/1306https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1021/1307https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1021/1308São José do Rio Preto; BrazilModernby sexSão José do Rio Preto; BrasilModernapor sexoDireitos autorais 2018 Rev. Bras. Odontol.http://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess2019-08-06T15:46:42Zoai:revista_aborj_org_br.www.revista.aborj.org.br:article/1021Revistahttps://revista.aborj.org.br/index.php/rboONGhttp://www.revista.aborj.org.br/index.php/rbo/oaihttps://revista.aborj.org.br/index.php/rbo/oai0034-72721984-3747opendoar:2019-08-06T15:46:42Revista Brasileira de Odontologia - Associação Brasileira de Odontologia (ABO)false |
dc.title.none.fl_str_mv |
Analysis of drug interactions in dental prescriptions. Análise de interações medicamentosas em prescrições dentárias |
title |
Analysis of drug interactions in dental prescriptions. |
spellingShingle |
Analysis of drug interactions in dental prescriptions. Furini, Adriana Antônia da Cruz PHARMACOLOGY Drug Interactions; Dentistry; Non-steroidal anti-inflammatory drugs; Anti-Infectious. MEDICINA DENTÁRIA (ODONTOLOGIA) Interações medicamentosas; Odontologia; Anti-inflamatórios não esteróides; Anti-infeccioso |
title_short |
Analysis of drug interactions in dental prescriptions. |
title_full |
Analysis of drug interactions in dental prescriptions. |
title_fullStr |
Analysis of drug interactions in dental prescriptions. |
title_full_unstemmed |
Analysis of drug interactions in dental prescriptions. |
title_sort |
Analysis of drug interactions in dental prescriptions. |
author |
Furini, Adriana Antônia da Cruz |
author_facet |
Furini, Adriana Antônia da Cruz Malagoli, Juliana Mendes de Almeida Dias, Nayane Justi Lima, Bruna Miranda Bonjardin, Manuela Manzano Machado, Ponatyellen Souza Lima, Tiago Aparecido Maschio de |
author_role |
author |
author2 |
Malagoli, Juliana Mendes de Almeida Dias, Nayane Justi Lima, Bruna Miranda Bonjardin, Manuela Manzano Machado, Ponatyellen Souza Lima, Tiago Aparecido Maschio de |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
|
dc.contributor.author.fl_str_mv |
Furini, Adriana Antônia da Cruz Malagoli, Juliana Mendes de Almeida Dias, Nayane Justi Lima, Bruna Miranda Bonjardin, Manuela Manzano Machado, Ponatyellen Souza Lima, Tiago Aparecido Maschio de |
dc.subject.none.fl_str_mv |
|
dc.subject.por.fl_str_mv |
PHARMACOLOGY Drug Interactions; Dentistry; Non-steroidal anti-inflammatory drugs; Anti-Infectious. MEDICINA DENTÁRIA (ODONTOLOGIA) Interações medicamentosas; Odontologia; Anti-inflamatórios não esteróides; Anti-infeccioso |
topic |
PHARMACOLOGY Drug Interactions; Dentistry; Non-steroidal anti-inflammatory drugs; Anti-Infectious. MEDICINA DENTÁRIA (ODONTOLOGIA) Interações medicamentosas; Odontologia; Anti-inflamatórios não esteróides; Anti-infeccioso |
description |
Objective: to evaluate the potential drug interactions (DI) in prescriptions for patients of a private university’s dental clinic. Material and Methods: this is an exploratory descriptive study. A total of 204 dental prescriptions were analyzed between April 2015 and October 2016. The databases for the analysis of DI potential wereaccessed through the programs Medscape, Drugs.com and Micromedex.The DIs were classified by intensity in major, moderate and minor. Results: the mean age was 43 ± 14 years old and 61% of the participants were female. Hypertension and Type II diabetes were the most prevalent diseases. 237 non-steroidal anti-inflammatory drugs were prescribed, with nimesulide being the most prevalent in the prescriptions, followed by dipyrone with analgesic and antipyretic effect. Of these, eighty-nine were antimicrobials, mostly amoxicillin. We identified 95 potential drug interactions, 28% being of major intensity and 67% of moderate intensity. Twelve interactions involved non-steroidal anti-inflammatory drugs, mainly ketoprofen, diclofenac and ibuprofen; and nine were related to the antimicrobials amoxicillin, metronizadol and azithromycin. Conclusion: The need for a careful analysis of dental prescriptions and a review of the concomitant therapy used by patients, reducing the risk of interactions, and consequently, preventing adverse reactions and preserving the patients’ safety, are observed. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-07-26 |
dc.type.none.fl_str_mv |
|
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Original Article Artigo Original |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revista.aborj.org.br/index.php/rbo/article/view/1021 10.18363/rbo.v75.2018.e1021 |
url |
https://revista.aborj.org.br/index.php/rbo/article/view/1021 |
identifier_str_mv |
10.18363/rbo.v75.2018.e1021 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revista.aborj.org.br/index.php/rbo/article/view/1021/682 https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1021/1306 https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1021/1307 https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1021/1308 |
dc.rights.driver.fl_str_mv |
Direitos autorais 2018 Rev. Bras. Odontol. http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Direitos autorais 2018 Rev. Bras. Odontol. http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
São José do Rio Preto; Brazil Modern by sex São José do Rio Preto; Brasil Moderna por sexo |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Odontologia - Seção Rio de Janeiro |
publisher.none.fl_str_mv |
Associação Brasileira de Odontologia - Seção Rio de Janeiro |
dc.source.none.fl_str_mv |
Revista Brasileira de Odontologia; v. 75 (2018); 1/6 Revista Brasileira de Odontologia; v. 75 (2018); 1/6 1984-3747 reponame:Revista Brasileira de Odontologia instname:Associação Brasileira de Odontologia (ABO) instacron:ABO |
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Associação Brasileira de Odontologia (ABO) |
instacron_str |
ABO |
institution |
ABO |
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Revista Brasileira de Odontologia |
collection |
Revista Brasileira de Odontologia |
repository.name.fl_str_mv |
Revista Brasileira de Odontologia - Associação Brasileira de Odontologia (ABO) |
repository.mail.fl_str_mv |
https://revista.aborj.org.br/index.php/rbo/oai |
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1798313204824145920 |