Spontaneous healing of the tympanic membrane after traumatic perforation in rats

Detalhes bibliográficos
Autor(a) principal: Araújo,Marcos Miranda de
Data de Publicação: 2014
Outros Autores: Murashima,Adriana Andrade Batista, Alves,Vani Maria, Jamur,Maria Celia, Hyppolito,Miguel Angelo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Otorhinolaryngology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942014000400330
Resumo: OBJECTIVE: The objective of the present study was to assess the healing of traumatic tympanic membrane perforation in rats. METHODS: The tympanic membrane from male Wistar rats was perforated in the anterior and posterior portions to the handle of the malleus. Five tympanic membranes were evaluated 3 days after tympanic perforation; 5 after 5 days; 5 after 7 days; 3 after 10 days; and 4 after 14 days. The tympanic membranes were submitted to histopathological evaluation after hematoxylin-eosin staining. RESULTS: Tympanic membrane closure occurred at about 7-10 days after injury and the healing process was complete by day 14. The proliferative activity of the outer epithelial layer was present close to the handle of the malleus and to the tympanic annulus. CONCLUSION: The spontaneous healing process of the tympanic membrane starts from the outer epithelial layer, with later healing of the lamina propria and the mucosal layer.
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spelling Spontaneous healing of the tympanic membrane after traumatic perforation in rats Tympanic membrane perforationWound healingHistology OBJECTIVE: The objective of the present study was to assess the healing of traumatic tympanic membrane perforation in rats. METHODS: The tympanic membrane from male Wistar rats was perforated in the anterior and posterior portions to the handle of the malleus. Five tympanic membranes were evaluated 3 days after tympanic perforation; 5 after 5 days; 5 after 7 days; 3 after 10 days; and 4 after 14 days. The tympanic membranes were submitted to histopathological evaluation after hematoxylin-eosin staining. RESULTS: Tympanic membrane closure occurred at about 7-10 days after injury and the healing process was complete by day 14. The proliferative activity of the outer epithelial layer was present close to the handle of the malleus and to the tympanic annulus. CONCLUSION: The spontaneous healing process of the tympanic membrane starts from the outer epithelial layer, with later healing of the lamina propria and the mucosal layer. Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.2014-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942014000400330Brazilian Journal of Otorhinolaryngology v.80 n.4 2014reponame:Brazilian Journal of Otorhinolaryngologyinstname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)instacron:ABORL-CCF10.1016/j.bjorl.2014.05.014info:eu-repo/semantics/openAccessAraújo,Marcos Miranda deMurashima,Adriana Andrade BatistaAlves,Vani MariaJamur,Maria CeliaHyppolito,Miguel Angeloeng2015-08-25T00:00:00Zoai:scielo:S1808-86942014000400330Revistahttp://www.bjorl.org.br/https://old.scielo.br/oai/scielo-oai.phprevista@aborlccf.org.br||revista@aborlccf.org.br1808-86861808-8686opendoar:2015-08-25T00:00Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)false
dc.title.none.fl_str_mv Spontaneous healing of the tympanic membrane after traumatic perforation in rats
title Spontaneous healing of the tympanic membrane after traumatic perforation in rats
spellingShingle Spontaneous healing of the tympanic membrane after traumatic perforation in rats
Araújo,Marcos Miranda de
Tympanic membrane perforation
Wound healing
Histology
title_short Spontaneous healing of the tympanic membrane after traumatic perforation in rats
title_full Spontaneous healing of the tympanic membrane after traumatic perforation in rats
title_fullStr Spontaneous healing of the tympanic membrane after traumatic perforation in rats
title_full_unstemmed Spontaneous healing of the tympanic membrane after traumatic perforation in rats
title_sort Spontaneous healing of the tympanic membrane after traumatic perforation in rats
author Araújo,Marcos Miranda de
author_facet Araújo,Marcos Miranda de
Murashima,Adriana Andrade Batista
Alves,Vani Maria
Jamur,Maria Celia
Hyppolito,Miguel Angelo
author_role author
author2 Murashima,Adriana Andrade Batista
Alves,Vani Maria
Jamur,Maria Celia
Hyppolito,Miguel Angelo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Araújo,Marcos Miranda de
Murashima,Adriana Andrade Batista
Alves,Vani Maria
Jamur,Maria Celia
Hyppolito,Miguel Angelo
dc.subject.por.fl_str_mv Tympanic membrane perforation
Wound healing
Histology
topic Tympanic membrane perforation
Wound healing
Histology
description OBJECTIVE: The objective of the present study was to assess the healing of traumatic tympanic membrane perforation in rats. METHODS: The tympanic membrane from male Wistar rats was perforated in the anterior and posterior portions to the handle of the malleus. Five tympanic membranes were evaluated 3 days after tympanic perforation; 5 after 5 days; 5 after 7 days; 3 after 10 days; and 4 after 14 days. The tympanic membranes were submitted to histopathological evaluation after hematoxylin-eosin staining. RESULTS: Tympanic membrane closure occurred at about 7-10 days after injury and the healing process was complete by day 14. The proliferative activity of the outer epithelial layer was present close to the handle of the malleus and to the tympanic annulus. CONCLUSION: The spontaneous healing process of the tympanic membrane starts from the outer epithelial layer, with later healing of the lamina propria and the mucosal layer.
publishDate 2014
dc.date.none.fl_str_mv 2014-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942014000400330
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942014000400330
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjorl.2014.05.014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.
publisher.none.fl_str_mv Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.
dc.source.none.fl_str_mv Brazilian Journal of Otorhinolaryngology v.80 n.4 2014
reponame:Brazilian Journal of Otorhinolaryngology
instname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
instacron:ABORL-CCF
instname_str Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
instacron_str ABORL-CCF
institution ABORL-CCF
reponame_str Brazilian Journal of Otorhinolaryngology
collection Brazilian Journal of Otorhinolaryngology
repository.name.fl_str_mv Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
repository.mail.fl_str_mv revista@aborlccf.org.br||revista@aborlccf.org.br
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