Experimental study on the effects of bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosa
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Otorhinolaryngology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942016000100017 |
Resumo: | ABSTRACT INTRODUCTION: Bismuth subgallate is a salt derived from heavy metal. The aim of this study was to evaluate the effect of this salt on some phases of healing. OBJECTIVES: To assess the effect of subgallate on mucosa and to evaluate the association between the use of bismuth subgallate and neogenesis of vessels in oral mucosal wounds. METHODS: This was a prospective and experimental study. This study used sixty rats, which were divided into control and experimental groups. The animals were submitted to a surgical procedure, which caused oral mucosal injury. A saline solution was applied on the wound of the control group, and in the experimental group, a solution of bismuth subgallate was administrated. RESULTS: The experimental group showed greater inflammatory reaction with increasing monomorphic proliferation. There was increased vessel proliferation in the control group. CONCLUSION: Bismuth subgallate had a negative influence on the healing process, delaying the rate of new vessel formation and optimal wound healing. |
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Brazilian Journal of Otorhinolaryngology |
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Experimental study on the effects of bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosaWound healingTonsillectomyAngiogenesis-inducing agentsABSTRACT INTRODUCTION: Bismuth subgallate is a salt derived from heavy metal. The aim of this study was to evaluate the effect of this salt on some phases of healing. OBJECTIVES: To assess the effect of subgallate on mucosa and to evaluate the association between the use of bismuth subgallate and neogenesis of vessels in oral mucosal wounds. METHODS: This was a prospective and experimental study. This study used sixty rats, which were divided into control and experimental groups. The animals were submitted to a surgical procedure, which caused oral mucosal injury. A saline solution was applied on the wound of the control group, and in the experimental group, a solution of bismuth subgallate was administrated. RESULTS: The experimental group showed greater inflammatory reaction with increasing monomorphic proliferation. There was increased vessel proliferation in the control group. CONCLUSION: Bismuth subgallate had a negative influence on the healing process, delaying the rate of new vessel formation and optimal wound healing.Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.2016-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942016000100017Brazilian Journal of Otorhinolaryngology v.82 n.1 2016reponame:Brazilian Journal of Otorhinolaryngologyinstname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)instacron:ABORL-CCF10.1016/j.bjorl.2014.12.009info:eu-repo/semantics/openAccessCouto,Eduardo VieiraBallin,Carlos RobertoSampaio,Claudia Paraguaçu PupoMaeda,Carlos Augusto SeijeBallin,Carlos HenriqueDassi,Camila SoaresYukari Miura,Lilianeng2016-03-04T00:00:00Zoai:scielo:S1808-86942016000100017Revistahttp://www.bjorl.org.br/https://old.scielo.br/oai/scielo-oai.phprevista@aborlccf.org.br||revista@aborlccf.org.br1808-86861808-8686opendoar:2016-03-04T00:00Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)false |
dc.title.none.fl_str_mv |
Experimental study on the effects of bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosa |
title |
Experimental study on the effects of bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosa |
spellingShingle |
Experimental study on the effects of bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosa Couto,Eduardo Vieira Wound healing Tonsillectomy Angiogenesis-inducing agents |
title_short |
Experimental study on the effects of bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosa |
title_full |
Experimental study on the effects of bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosa |
title_fullStr |
Experimental study on the effects of bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosa |
title_full_unstemmed |
Experimental study on the effects of bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosa |
title_sort |
Experimental study on the effects of bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosa |
author |
Couto,Eduardo Vieira |
author_facet |
Couto,Eduardo Vieira Ballin,Carlos Roberto Sampaio,Claudia Paraguaçu Pupo Maeda,Carlos Augusto Seije Ballin,Carlos Henrique Dassi,Camila Soares Yukari Miura,Lilian |
author_role |
author |
author2 |
Ballin,Carlos Roberto Sampaio,Claudia Paraguaçu Pupo Maeda,Carlos Augusto Seije Ballin,Carlos Henrique Dassi,Camila Soares Yukari Miura,Lilian |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Couto,Eduardo Vieira Ballin,Carlos Roberto Sampaio,Claudia Paraguaçu Pupo Maeda,Carlos Augusto Seije Ballin,Carlos Henrique Dassi,Camila Soares Yukari Miura,Lilian |
dc.subject.por.fl_str_mv |
Wound healing Tonsillectomy Angiogenesis-inducing agents |
topic |
Wound healing Tonsillectomy Angiogenesis-inducing agents |
description |
ABSTRACT INTRODUCTION: Bismuth subgallate is a salt derived from heavy metal. The aim of this study was to evaluate the effect of this salt on some phases of healing. OBJECTIVES: To assess the effect of subgallate on mucosa and to evaluate the association between the use of bismuth subgallate and neogenesis of vessels in oral mucosal wounds. METHODS: This was a prospective and experimental study. This study used sixty rats, which were divided into control and experimental groups. The animals were submitted to a surgical procedure, which caused oral mucosal injury. A saline solution was applied on the wound of the control group, and in the experimental group, a solution of bismuth subgallate was administrated. RESULTS: The experimental group showed greater inflammatory reaction with increasing monomorphic proliferation. There was increased vessel proliferation in the control group. CONCLUSION: Bismuth subgallate had a negative influence on the healing process, delaying the rate of new vessel formation and optimal wound healing. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942016000100017 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942016000100017 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjorl.2014.12.009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. |
publisher.none.fl_str_mv |
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. |
dc.source.none.fl_str_mv |
Brazilian Journal of Otorhinolaryngology v.82 n.1 2016 reponame:Brazilian Journal of Otorhinolaryngology instname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF) instacron:ABORL-CCF |
instname_str |
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF) |
instacron_str |
ABORL-CCF |
institution |
ABORL-CCF |
reponame_str |
Brazilian Journal of Otorhinolaryngology |
collection |
Brazilian Journal of Otorhinolaryngology |
repository.name.fl_str_mv |
Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF) |
repository.mail.fl_str_mv |
revista@aborlccf.org.br||revista@aborlccf.org.br |
_version_ |
1754575991736369152 |