Association between interleukin-6 polymorphism in the -174 G/C region and hearing loss in the elderly with a history of occupational noise exposure
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Otorhinolaryngology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942014000500373 |
Resumo: | INTRODUCTION: The biological processes involved in noise-induced hearing loss (NIHL) are still unclear. The involvement of inflammation in this condition has been suggested. OBJECTIVE: To investigate the association between interleukin - 6 (IL-6) polymorphism and susceptibility to NIHL. METHODS: This was a cross-sectional study with a sample of 191 independent elderly individuals aged > 60 years of age. Information on exposure to occupational noise was obtained by interviews. Audiological evaluation was performed using pure tone audiometry and genotyped through PCR by restriction fragment length polymorphism - PCR-RFLP. Data were analyzed using the Chi-square test and the Odds ratio (OR), with the significance level set at 5%. RESULTS: Among elderly with hearing loss (78.0%), 18.8% had a history of exposure to occupational noise. There was a statistically significant association between the genotype frequencies of the IL-6 -174 and NIHL. The elderly with the CC genotype were less likely to have hearing loss due to occupational noise exposure when compared to those carrying the GG genotype (OR = 0.0124; 95% CI 0.0023-0.0671; p < 0.001). CONCLUSION: This study suggests there is an association of polymorphisms in the IL- 6 gene at position - G174C with susceptibility to noise-induced hearing loss. |
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Brazilian Journal of Otorhinolaryngology |
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Association between interleukin-6 polymorphism in the -174 G/C region and hearing loss in the elderly with a history of occupational noise exposure Occupational noise Sensorineural hearing lossCytokines INTRODUCTION: The biological processes involved in noise-induced hearing loss (NIHL) are still unclear. The involvement of inflammation in this condition has been suggested. OBJECTIVE: To investigate the association between interleukin - 6 (IL-6) polymorphism and susceptibility to NIHL. METHODS: This was a cross-sectional study with a sample of 191 independent elderly individuals aged > 60 years of age. Information on exposure to occupational noise was obtained by interviews. Audiological evaluation was performed using pure tone audiometry and genotyped through PCR by restriction fragment length polymorphism - PCR-RFLP. Data were analyzed using the Chi-square test and the Odds ratio (OR), with the significance level set at 5%. RESULTS: Among elderly with hearing loss (78.0%), 18.8% had a history of exposure to occupational noise. There was a statistically significant association between the genotype frequencies of the IL-6 -174 and NIHL. The elderly with the CC genotype were less likely to have hearing loss due to occupational noise exposure when compared to those carrying the GG genotype (OR = 0.0124; 95% CI 0.0023-0.0671; p < 0.001). CONCLUSION: This study suggests there is an association of polymorphisms in the IL- 6 gene at position - G174C with susceptibility to noise-induced hearing loss. Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.2014-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942014000500373Brazilian Journal of Otorhinolaryngology v.80 n.5 2014reponame:Brazilian Journal of Otorhinolaryngologyinstname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)instacron:ABORL-CCF10.1016/j.bjorl.2014.07.001info:eu-repo/semantics/openAccessBraga,Miula PortelinhaMaciel,Sandra MaraMarchiori,Luciana Lozza de MoraesPoli-Frederico,Regina Céliaeng2015-08-25T00:00:00Zoai:scielo:S1808-86942014000500373Revistahttp://www.bjorl.org.br/https://old.scielo.br/oai/scielo-oai.phprevista@aborlccf.org.br||revista@aborlccf.org.br1808-86861808-8686opendoar:2015-08-25T00:00Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)false |
dc.title.none.fl_str_mv |
Association between interleukin-6 polymorphism in the -174 G/C region and hearing loss in the elderly with a history of occupational noise exposure |
title |
Association between interleukin-6 polymorphism in the -174 G/C region and hearing loss in the elderly with a history of occupational noise exposure |
spellingShingle |
Association between interleukin-6 polymorphism in the -174 G/C region and hearing loss in the elderly with a history of occupational noise exposure Braga,Miula Portelinha Occupational noise Sensorineural hearing loss Cytokines |
title_short |
Association between interleukin-6 polymorphism in the -174 G/C region and hearing loss in the elderly with a history of occupational noise exposure |
title_full |
Association between interleukin-6 polymorphism in the -174 G/C region and hearing loss in the elderly with a history of occupational noise exposure |
title_fullStr |
Association between interleukin-6 polymorphism in the -174 G/C region and hearing loss in the elderly with a history of occupational noise exposure |
title_full_unstemmed |
Association between interleukin-6 polymorphism in the -174 G/C region and hearing loss in the elderly with a history of occupational noise exposure |
title_sort |
Association between interleukin-6 polymorphism in the -174 G/C region and hearing loss in the elderly with a history of occupational noise exposure |
author |
Braga,Miula Portelinha |
author_facet |
Braga,Miula Portelinha Maciel,Sandra Mara Marchiori,Luciana Lozza de Moraes Poli-Frederico,Regina Célia |
author_role |
author |
author2 |
Maciel,Sandra Mara Marchiori,Luciana Lozza de Moraes Poli-Frederico,Regina Célia |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Braga,Miula Portelinha Maciel,Sandra Mara Marchiori,Luciana Lozza de Moraes Poli-Frederico,Regina Célia |
dc.subject.por.fl_str_mv |
Occupational noise Sensorineural hearing loss Cytokines |
topic |
Occupational noise Sensorineural hearing loss Cytokines |
description |
INTRODUCTION: The biological processes involved in noise-induced hearing loss (NIHL) are still unclear. The involvement of inflammation in this condition has been suggested. OBJECTIVE: To investigate the association between interleukin - 6 (IL-6) polymorphism and susceptibility to NIHL. METHODS: This was a cross-sectional study with a sample of 191 independent elderly individuals aged > 60 years of age. Information on exposure to occupational noise was obtained by interviews. Audiological evaluation was performed using pure tone audiometry and genotyped through PCR by restriction fragment length polymorphism - PCR-RFLP. Data were analyzed using the Chi-square test and the Odds ratio (OR), with the significance level set at 5%. RESULTS: Among elderly with hearing loss (78.0%), 18.8% had a history of exposure to occupational noise. There was a statistically significant association between the genotype frequencies of the IL-6 -174 and NIHL. The elderly with the CC genotype were less likely to have hearing loss due to occupational noise exposure when compared to those carrying the GG genotype (OR = 0.0124; 95% CI 0.0023-0.0671; p < 0.001). CONCLUSION: This study suggests there is an association of polymorphisms in the IL- 6 gene at position - G174C with susceptibility to noise-induced hearing loss. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942014000500373 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942014000500373 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjorl.2014.07.001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. |
publisher.none.fl_str_mv |
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. |
dc.source.none.fl_str_mv |
Brazilian Journal of Otorhinolaryngology v.80 n.5 2014 reponame:Brazilian Journal of Otorhinolaryngology instname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF) instacron:ABORL-CCF |
instname_str |
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF) |
instacron_str |
ABORL-CCF |
institution |
ABORL-CCF |
reponame_str |
Brazilian Journal of Otorhinolaryngology |
collection |
Brazilian Journal of Otorhinolaryngology |
repository.name.fl_str_mv |
Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF) |
repository.mail.fl_str_mv |
revista@aborlccf.org.br||revista@aborlccf.org.br |
_version_ |
1754575991278141441 |