Mucosa-associated lymphoid tissue in individuals with AIDS

Detalhes bibliográficos
Autor(a) principal: Olegario,Janainna Grazielle Pacheco
Data de Publicação: 2011
Outros Autores: Silva,Renata Calciolari Rossi e, Teixeira,Vicente de Paula Antunes, Castro,Eumênia Costa da Cunha, Corrêa,Rosana Rosa Miranda
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Otorhinolaryngology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942011000300007
Resumo: Vestibular folds (VF) protect upper airways, but contain fewer immune cells in AIDS patients, which affects the structure of lymphoid follicles (LF). OBJECTIVE: To characterize fibrosis and immunoglobulin production in vestibular fold lymphoid tissues of AIDS patients with or with no infection and malnutrition. MATERIALS AND METHODS: A retrospective study of 71 adult vestibular fold autopsy specimens. The morphological analysis was done using the picrosirius staining method. Immunohistochemical methods consisted of anti-IgA, anti IgG, and anti IgM antibodies. RESULTS: Fibrosis was less intense in AIDS patients compared to subjects without AIDS; the same applied to patients with infection or malnutrition. IgA and IgG titers were higher in AIDS patients; IgM titers were higher in cases with infection. CONCLUSION: This study helps understand variations in lymphoid follicle components of AIDS patients; it also shows the influence of architectural changes and the effect of associated respiratory infection and malnutrition on lymphoid follicle function.
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spelling Mucosa-associated lymphoid tissue in individuals with AIDSacquired immunodeficiency syndromefibrosisimmunoglobulinslymphoid tissueVestibular folds (VF) protect upper airways, but contain fewer immune cells in AIDS patients, which affects the structure of lymphoid follicles (LF). OBJECTIVE: To characterize fibrosis and immunoglobulin production in vestibular fold lymphoid tissues of AIDS patients with or with no infection and malnutrition. MATERIALS AND METHODS: A retrospective study of 71 adult vestibular fold autopsy specimens. The morphological analysis was done using the picrosirius staining method. Immunohistochemical methods consisted of anti-IgA, anti IgG, and anti IgM antibodies. RESULTS: Fibrosis was less intense in AIDS patients compared to subjects without AIDS; the same applied to patients with infection or malnutrition. IgA and IgG titers were higher in AIDS patients; IgM titers were higher in cases with infection. CONCLUSION: This study helps understand variations in lymphoid follicle components of AIDS patients; it also shows the influence of architectural changes and the effect of associated respiratory infection and malnutrition on lymphoid follicle function.Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.2011-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942011000300007Brazilian Journal of Otorhinolaryngology v.77 n.3 2011reponame:Brazilian Journal of Otorhinolaryngologyinstname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)instacron:ABORL-CCF10.1590/S1808-86942011000300007info:eu-repo/semantics/openAccessOlegario,Janainna Grazielle PachecoSilva,Renata Calciolari Rossi eTeixeira,Vicente de Paula AntunesCastro,Eumênia Costa da CunhaCorrêa,Rosana Rosa Mirandaeng2011-08-30T00:00:00Zoai:scielo:S1808-86942011000300007Revistahttp://www.bjorl.org.br/https://old.scielo.br/oai/scielo-oai.phprevista@aborlccf.org.br||revista@aborlccf.org.br1808-86861808-8686opendoar:2011-08-30T00:00Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)false
dc.title.none.fl_str_mv Mucosa-associated lymphoid tissue in individuals with AIDS
title Mucosa-associated lymphoid tissue in individuals with AIDS
spellingShingle Mucosa-associated lymphoid tissue in individuals with AIDS
Olegario,Janainna Grazielle Pacheco
acquired immunodeficiency syndrome
fibrosis
immunoglobulins
lymphoid tissue
title_short Mucosa-associated lymphoid tissue in individuals with AIDS
title_full Mucosa-associated lymphoid tissue in individuals with AIDS
title_fullStr Mucosa-associated lymphoid tissue in individuals with AIDS
title_full_unstemmed Mucosa-associated lymphoid tissue in individuals with AIDS
title_sort Mucosa-associated lymphoid tissue in individuals with AIDS
author Olegario,Janainna Grazielle Pacheco
author_facet Olegario,Janainna Grazielle Pacheco
Silva,Renata Calciolari Rossi e
Teixeira,Vicente de Paula Antunes
Castro,Eumênia Costa da Cunha
Corrêa,Rosana Rosa Miranda
author_role author
author2 Silva,Renata Calciolari Rossi e
Teixeira,Vicente de Paula Antunes
Castro,Eumênia Costa da Cunha
Corrêa,Rosana Rosa Miranda
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Olegario,Janainna Grazielle Pacheco
Silva,Renata Calciolari Rossi e
Teixeira,Vicente de Paula Antunes
Castro,Eumênia Costa da Cunha
Corrêa,Rosana Rosa Miranda
dc.subject.por.fl_str_mv acquired immunodeficiency syndrome
fibrosis
immunoglobulins
lymphoid tissue
topic acquired immunodeficiency syndrome
fibrosis
immunoglobulins
lymphoid tissue
description Vestibular folds (VF) protect upper airways, but contain fewer immune cells in AIDS patients, which affects the structure of lymphoid follicles (LF). OBJECTIVE: To characterize fibrosis and immunoglobulin production in vestibular fold lymphoid tissues of AIDS patients with or with no infection and malnutrition. MATERIALS AND METHODS: A retrospective study of 71 adult vestibular fold autopsy specimens. The morphological analysis was done using the picrosirius staining method. Immunohistochemical methods consisted of anti-IgA, anti IgG, and anti IgM antibodies. RESULTS: Fibrosis was less intense in AIDS patients compared to subjects without AIDS; the same applied to patients with infection or malnutrition. IgA and IgG titers were higher in AIDS patients; IgM titers were higher in cases with infection. CONCLUSION: This study helps understand variations in lymphoid follicle components of AIDS patients; it also shows the influence of architectural changes and the effect of associated respiratory infection and malnutrition on lymphoid follicle function.
publishDate 2011
dc.date.none.fl_str_mv 2011-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942011000300007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942011000300007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1808-86942011000300007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.
publisher.none.fl_str_mv Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.
dc.source.none.fl_str_mv Brazilian Journal of Otorhinolaryngology v.77 n.3 2011
reponame:Brazilian Journal of Otorhinolaryngology
instname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
instacron:ABORL-CCF
instname_str Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
instacron_str ABORL-CCF
institution ABORL-CCF
reponame_str Brazilian Journal of Otorhinolaryngology
collection Brazilian Journal of Otorhinolaryngology
repository.name.fl_str_mv Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
repository.mail.fl_str_mv revista@aborlccf.org.br||revista@aborlccf.org.br
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