Behavioral, affective, and cognitive alterations induced by individual and combined environmental stressors in rats
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462019000400289 |
Resumo: | Objective: To evaluate whether exposing rats to individual or combined environmental stressors triggers endophenotypes related to mood and anxiety disorders, and whether this effect depends on the nature of the behavior (i.e., innate or learned). Methods: We conducted a three-phase experimental protocol. In phase I (baseline), animals subjected to mixed schedule of reinforcement were trained to press a lever with a fixed interval of 1 minute and a limited hold of 3 seconds. On the last day of phase I, an open-field test was performed and the animals were divided into four experimental groups (n=8/group). In phase II (repeated stress), each group was exposed to either hot air blast (HAB), paradoxical sleep deprivation (PSD) or both (HAB+PSD group) on alternate days over a 10-day period. Control group animals were not exposed to stressors. In phase III (post-stress evaluation), behavior was analyzed on the first (short-term effects), third (mid-term effects), and fifth (long-term effects) days after repeated stress. Results: The PSD group presented operant hyperactivity, the HAB group presented spontaneous hypoactivity and anxiety, and the HAB+PSD group presented spontaneous hyperactivity, operant hypoactivity, impulsivity, loss of interest, and cognitive impairment. Conclusion: A combination of environmental stressors (HAB and PSD) may induce endophenotypes related to bipolar disorder. |
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Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
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Behavioral, affective, and cognitive alterations induced by individual and combined environmental stressors in ratsAnimal modelcombined stressorsparadoxical sleep deprivationhot air blastbipolar disorder Objective: To evaluate whether exposing rats to individual or combined environmental stressors triggers endophenotypes related to mood and anxiety disorders, and whether this effect depends on the nature of the behavior (i.e., innate or learned). Methods: We conducted a three-phase experimental protocol. In phase I (baseline), animals subjected to mixed schedule of reinforcement were trained to press a lever with a fixed interval of 1 minute and a limited hold of 3 seconds. On the last day of phase I, an open-field test was performed and the animals were divided into four experimental groups (n=8/group). In phase II (repeated stress), each group was exposed to either hot air blast (HAB), paradoxical sleep deprivation (PSD) or both (HAB+PSD group) on alternate days over a 10-day period. Control group animals were not exposed to stressors. In phase III (post-stress evaluation), behavior was analyzed on the first (short-term effects), third (mid-term effects), and fifth (long-term effects) days after repeated stress. Results: The PSD group presented operant hyperactivity, the HAB group presented spontaneous hypoactivity and anxiety, and the HAB+PSD group presented spontaneous hyperactivity, operant hypoactivity, impulsivity, loss of interest, and cognitive impairment. Conclusion: A combination of environmental stressors (HAB and PSD) may induce endophenotypes related to bipolar disorder.Associação Brasileira de Psiquiatria2019-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462019000400289Brazilian Journal of Psychiatry v.41 n.4 2019reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABP10.1590/1516-4446-2018-0009info:eu-repo/semantics/openAccessRabelo-da-Ponte,Francisco DiegoPessoa Gomes,Jessica MariaTorres,Nathércia LimaBarbosa,João Ilo Coelhode Andrade,Geanne MatosMacedo,DanielleCeppi,Brunoeng2019-10-11T00:00:00Zoai:scielo:S1516-44462019000400289Revistahttp://www.bjp.org.br/ahead_of_print.asphttps://old.scielo.br/oai/scielo-oai.php||rbp@abpbrasil.org.br1809-452X1516-4446opendoar:2019-10-11T00:00Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)false |
dc.title.none.fl_str_mv |
Behavioral, affective, and cognitive alterations induced by individual and combined environmental stressors in rats |
title |
Behavioral, affective, and cognitive alterations induced by individual and combined environmental stressors in rats |
spellingShingle |
Behavioral, affective, and cognitive alterations induced by individual and combined environmental stressors in rats Rabelo-da-Ponte,Francisco Diego Animal model combined stressors paradoxical sleep deprivation hot air blast bipolar disorder |
title_short |
Behavioral, affective, and cognitive alterations induced by individual and combined environmental stressors in rats |
title_full |
Behavioral, affective, and cognitive alterations induced by individual and combined environmental stressors in rats |
title_fullStr |
Behavioral, affective, and cognitive alterations induced by individual and combined environmental stressors in rats |
title_full_unstemmed |
Behavioral, affective, and cognitive alterations induced by individual and combined environmental stressors in rats |
title_sort |
Behavioral, affective, and cognitive alterations induced by individual and combined environmental stressors in rats |
author |
Rabelo-da-Ponte,Francisco Diego |
author_facet |
Rabelo-da-Ponte,Francisco Diego Pessoa Gomes,Jessica Maria Torres,Nathércia Lima Barbosa,João Ilo Coelho de Andrade,Geanne Matos Macedo,Danielle Ceppi,Bruno |
author_role |
author |
author2 |
Pessoa Gomes,Jessica Maria Torres,Nathércia Lima Barbosa,João Ilo Coelho de Andrade,Geanne Matos Macedo,Danielle Ceppi,Bruno |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Rabelo-da-Ponte,Francisco Diego Pessoa Gomes,Jessica Maria Torres,Nathércia Lima Barbosa,João Ilo Coelho de Andrade,Geanne Matos Macedo,Danielle Ceppi,Bruno |
dc.subject.por.fl_str_mv |
Animal model combined stressors paradoxical sleep deprivation hot air blast bipolar disorder |
topic |
Animal model combined stressors paradoxical sleep deprivation hot air blast bipolar disorder |
description |
Objective: To evaluate whether exposing rats to individual or combined environmental stressors triggers endophenotypes related to mood and anxiety disorders, and whether this effect depends on the nature of the behavior (i.e., innate or learned). Methods: We conducted a three-phase experimental protocol. In phase I (baseline), animals subjected to mixed schedule of reinforcement were trained to press a lever with a fixed interval of 1 minute and a limited hold of 3 seconds. On the last day of phase I, an open-field test was performed and the animals were divided into four experimental groups (n=8/group). In phase II (repeated stress), each group was exposed to either hot air blast (HAB), paradoxical sleep deprivation (PSD) or both (HAB+PSD group) on alternate days over a 10-day period. Control group animals were not exposed to stressors. In phase III (post-stress evaluation), behavior was analyzed on the first (short-term effects), third (mid-term effects), and fifth (long-term effects) days after repeated stress. Results: The PSD group presented operant hyperactivity, the HAB group presented spontaneous hypoactivity and anxiety, and the HAB+PSD group presented spontaneous hyperactivity, operant hypoactivity, impulsivity, loss of interest, and cognitive impairment. Conclusion: A combination of environmental stressors (HAB and PSD) may induce endophenotypes related to bipolar disorder. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462019000400289 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462019000400289 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1516-4446-2018-0009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
dc.source.none.fl_str_mv |
Brazilian Journal of Psychiatry v.41 n.4 2019 reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online) instname:Associação Brasileira de Psiquiatria (ABP) instacron:ABP |
instname_str |
Associação Brasileira de Psiquiatria (ABP) |
instacron_str |
ABP |
institution |
ABP |
reponame_str |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
collection |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
repository.name.fl_str_mv |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP) |
repository.mail.fl_str_mv |
||rbp@abpbrasil.org.br |
_version_ |
1754212558722564096 |