Structural and functional neuroimaging findings associated with the use of clozapine in schizophrenia: a systematic review

Detalhes bibliográficos
Autor(a) principal: Garcia,Giovana J.
Data de Publicação: 2015
Outros Autores: Chagas,Marcos H., Silva,Carlos H., Machado-de-Sousa,João P., Crippa,José A., Hallak,Jaime E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462015000100071
Resumo: Objective: Schizophrenia is one of the most severe psychiatric disorders, and its current treatment relies on antipsychotic medications with only partial effectiveness. Clozapine is an atypical antipsychotic with a specific profile of action indicated for treatment-resistant schizophrenia. Neuroimaging studies assessing the effects of clozapine could help shed light on the neural underpinnings of the effects of this drug in the brain. The objective of this study was to review the available literature on the structural and functional neuroimaging findings associated with use of clozapine. Method: We conducted a systematic review of the indexed literature using the PubMed, BIREME, and ISI Web of Knowledge search engines and the following keywords: clozapine, neuroimaging, computed tomography, MRI, functional magnetic resonance, PET, SPECT, and DTI. Results: A total of 23 articles were included in the review. In structural studies, the use of clozapine was associated with volume reductions in the basal ganglia, especially the caudate nucleus, where functional neuroimaging studies also found decreased perfusion. In the frontal lobe, clozapine treatment was associated with increased gray matter volume and reduced perfusion. Conclusion: The results of the studies reviewed suggest that the use of clozapine is associated with distinctive structural and functional neuroimaging findings that are not shared with other antipsychotics.
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spelling Structural and functional neuroimaging findings associated with the use of clozapine in schizophrenia: a systematic reviewClozapineneuroimagingschizophreniamagnetic resonancecomputed tomography Objective: Schizophrenia is one of the most severe psychiatric disorders, and its current treatment relies on antipsychotic medications with only partial effectiveness. Clozapine is an atypical antipsychotic with a specific profile of action indicated for treatment-resistant schizophrenia. Neuroimaging studies assessing the effects of clozapine could help shed light on the neural underpinnings of the effects of this drug in the brain. The objective of this study was to review the available literature on the structural and functional neuroimaging findings associated with use of clozapine. Method: We conducted a systematic review of the indexed literature using the PubMed, BIREME, and ISI Web of Knowledge search engines and the following keywords: clozapine, neuroimaging, computed tomography, MRI, functional magnetic resonance, PET, SPECT, and DTI. Results: A total of 23 articles were included in the review. In structural studies, the use of clozapine was associated with volume reductions in the basal ganglia, especially the caudate nucleus, where functional neuroimaging studies also found decreased perfusion. In the frontal lobe, clozapine treatment was associated with increased gray matter volume and reduced perfusion. Conclusion: The results of the studies reviewed suggest that the use of clozapine is associated with distinctive structural and functional neuroimaging findings that are not shared with other antipsychotics. Associação Brasileira de Psiquiatria2015-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462015000100071Brazilian Journal of Psychiatry v.37 n.1 2015reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABP10.1590/1516-4446-2014-1387info:eu-repo/semantics/openAccessGarcia,Giovana J.Chagas,Marcos H.Silva,Carlos H.Machado-de-Sousa,João P.Crippa,José A.Hallak,Jaime E.eng2015-03-19T00:00:00Zoai:scielo:S1516-44462015000100071Revistahttp://www.bjp.org.br/ahead_of_print.asphttps://old.scielo.br/oai/scielo-oai.php||rbp@abpbrasil.org.br1809-452X1516-4446opendoar:2015-03-19T00:00Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)false
dc.title.none.fl_str_mv Structural and functional neuroimaging findings associated with the use of clozapine in schizophrenia: a systematic review
title Structural and functional neuroimaging findings associated with the use of clozapine in schizophrenia: a systematic review
spellingShingle Structural and functional neuroimaging findings associated with the use of clozapine in schizophrenia: a systematic review
Garcia,Giovana J.
Clozapine
neuroimaging
schizophrenia
magnetic resonance
computed tomography
title_short Structural and functional neuroimaging findings associated with the use of clozapine in schizophrenia: a systematic review
title_full Structural and functional neuroimaging findings associated with the use of clozapine in schizophrenia: a systematic review
title_fullStr Structural and functional neuroimaging findings associated with the use of clozapine in schizophrenia: a systematic review
title_full_unstemmed Structural and functional neuroimaging findings associated with the use of clozapine in schizophrenia: a systematic review
title_sort Structural and functional neuroimaging findings associated with the use of clozapine in schizophrenia: a systematic review
author Garcia,Giovana J.
author_facet Garcia,Giovana J.
Chagas,Marcos H.
Silva,Carlos H.
Machado-de-Sousa,João P.
Crippa,José A.
Hallak,Jaime E.
author_role author
author2 Chagas,Marcos H.
Silva,Carlos H.
Machado-de-Sousa,João P.
Crippa,José A.
Hallak,Jaime E.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Garcia,Giovana J.
Chagas,Marcos H.
Silva,Carlos H.
Machado-de-Sousa,João P.
Crippa,José A.
Hallak,Jaime E.
dc.subject.por.fl_str_mv Clozapine
neuroimaging
schizophrenia
magnetic resonance
computed tomography
topic Clozapine
neuroimaging
schizophrenia
magnetic resonance
computed tomography
description Objective: Schizophrenia is one of the most severe psychiatric disorders, and its current treatment relies on antipsychotic medications with only partial effectiveness. Clozapine is an atypical antipsychotic with a specific profile of action indicated for treatment-resistant schizophrenia. Neuroimaging studies assessing the effects of clozapine could help shed light on the neural underpinnings of the effects of this drug in the brain. The objective of this study was to review the available literature on the structural and functional neuroimaging findings associated with use of clozapine. Method: We conducted a systematic review of the indexed literature using the PubMed, BIREME, and ISI Web of Knowledge search engines and the following keywords: clozapine, neuroimaging, computed tomography, MRI, functional magnetic resonance, PET, SPECT, and DTI. Results: A total of 23 articles were included in the review. In structural studies, the use of clozapine was associated with volume reductions in the basal ganglia, especially the caudate nucleus, where functional neuroimaging studies also found decreased perfusion. In the frontal lobe, clozapine treatment was associated with increased gray matter volume and reduced perfusion. Conclusion: The results of the studies reviewed suggest that the use of clozapine is associated with distinctive structural and functional neuroimaging findings that are not shared with other antipsychotics.
publishDate 2015
dc.date.none.fl_str_mv 2015-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462015000100071
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462015000100071
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1516-4446-2014-1387
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
dc.source.none.fl_str_mv Brazilian Journal of Psychiatry v.37 n.1 2015
reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
instname:Associação Brasileira de Psiquiatria (ABP)
instacron:ABP
instname_str Associação Brasileira de Psiquiatria (ABP)
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reponame_str Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
collection Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
repository.name.fl_str_mv Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)
repository.mail.fl_str_mv ||rbp@abpbrasil.org.br
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