Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients

Detalhes bibliográficos
Autor(a) principal: Dutra,Gustavo Pimentel
Data de Publicação: 2010
Outros Autores: Ottoni,Gustavo L., Lara,Diogo R., Bogo,Maurício Reis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462010000300011
Resumo: OBJECTIVE: Adenosine may play a role in the pathophysiology of schizophrenia, since it modulates the release of several neurotransmitters such as glutamate, dopamine, serotonin and acetylcholine, decreases neuronal activity by pos-synaptic hyperpolarization and inhibits dopaminergic activity. Adenosine deaminase participates in purine metabolism by converting adenosine into inosine. The most frequent functional polymorphism of adenosine deaminase (22G→A) (ADA1*2) exhibits 20-30% lower enzymatic activity in individuals with the G/A genotype than individuals with the G/G genotype. The aim of this study was to evaluate the ADA polymorphism 22G→A (ADA1*2) in schizophrenic patients and healthy controls. METHOD: The genotypes of the ADA 22G→A were identified with allele-specific PCR strategy in 152 schizophrenic patients and 111 healthy individuals. RESULTS: A significant decrease in the frequency of the G/A genotype was seen in schizophrenic patients (7/152 - 4.6%) relative to controls (13/111 - 11.7%, p = 0.032, OR = 2.6). CONCLUSION: These results suggest that the G/A genotype associated with low adenosine deaminase activity and, supposingly, with higher adenosine levels is less frequent among schizophrenic patients.
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spelling Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patientsPolymorphism, restriction fragment lengthAdenosineAdenosine deaminaseSchizophreniaGene frequencyOBJECTIVE: Adenosine may play a role in the pathophysiology of schizophrenia, since it modulates the release of several neurotransmitters such as glutamate, dopamine, serotonin and acetylcholine, decreases neuronal activity by pos-synaptic hyperpolarization and inhibits dopaminergic activity. Adenosine deaminase participates in purine metabolism by converting adenosine into inosine. The most frequent functional polymorphism of adenosine deaminase (22G→A) (ADA1*2) exhibits 20-30% lower enzymatic activity in individuals with the G/A genotype than individuals with the G/G genotype. The aim of this study was to evaluate the ADA polymorphism 22G→A (ADA1*2) in schizophrenic patients and healthy controls. METHOD: The genotypes of the ADA 22G→A were identified with allele-specific PCR strategy in 152 schizophrenic patients and 111 healthy individuals. RESULTS: A significant decrease in the frequency of the G/A genotype was seen in schizophrenic patients (7/152 - 4.6%) relative to controls (13/111 - 11.7%, p = 0.032, OR = 2.6). CONCLUSION: These results suggest that the G/A genotype associated with low adenosine deaminase activity and, supposingly, with higher adenosine levels is less frequent among schizophrenic patients.Associação Brasileira de Psiquiatria2010-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462010000300011Brazilian Journal of Psychiatry v.32 n.3 2010reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABP10.1590/S1516-44462010005000003info:eu-repo/semantics/openAccessDutra,Gustavo PimentelOttoni,Gustavo L.Lara,Diogo R.Bogo,Maurício Reiseng2010-10-01T00:00:00Zoai:scielo:S1516-44462010000300011Revistahttp://www.bjp.org.br/ahead_of_print.asphttps://old.scielo.br/oai/scielo-oai.php||rbp@abpbrasil.org.br1809-452X1516-4446opendoar:2010-10-01T00:00Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)false
dc.title.none.fl_str_mv Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients
title Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients
spellingShingle Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients
Dutra,Gustavo Pimentel
Polymorphism, restriction fragment length
Adenosine
Adenosine deaminase
Schizophrenia
Gene frequency
title_short Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients
title_full Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients
title_fullStr Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients
title_full_unstemmed Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients
title_sort Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients
author Dutra,Gustavo Pimentel
author_facet Dutra,Gustavo Pimentel
Ottoni,Gustavo L.
Lara,Diogo R.
Bogo,Maurício Reis
author_role author
author2 Ottoni,Gustavo L.
Lara,Diogo R.
Bogo,Maurício Reis
author2_role author
author
author
dc.contributor.author.fl_str_mv Dutra,Gustavo Pimentel
Ottoni,Gustavo L.
Lara,Diogo R.
Bogo,Maurício Reis
dc.subject.por.fl_str_mv Polymorphism, restriction fragment length
Adenosine
Adenosine deaminase
Schizophrenia
Gene frequency
topic Polymorphism, restriction fragment length
Adenosine
Adenosine deaminase
Schizophrenia
Gene frequency
description OBJECTIVE: Adenosine may play a role in the pathophysiology of schizophrenia, since it modulates the release of several neurotransmitters such as glutamate, dopamine, serotonin and acetylcholine, decreases neuronal activity by pos-synaptic hyperpolarization and inhibits dopaminergic activity. Adenosine deaminase participates in purine metabolism by converting adenosine into inosine. The most frequent functional polymorphism of adenosine deaminase (22G→A) (ADA1*2) exhibits 20-30% lower enzymatic activity in individuals with the G/A genotype than individuals with the G/G genotype. The aim of this study was to evaluate the ADA polymorphism 22G→A (ADA1*2) in schizophrenic patients and healthy controls. METHOD: The genotypes of the ADA 22G→A were identified with allele-specific PCR strategy in 152 schizophrenic patients and 111 healthy individuals. RESULTS: A significant decrease in the frequency of the G/A genotype was seen in schizophrenic patients (7/152 - 4.6%) relative to controls (13/111 - 11.7%, p = 0.032, OR = 2.6). CONCLUSION: These results suggest that the G/A genotype associated with low adenosine deaminase activity and, supposingly, with higher adenosine levels is less frequent among schizophrenic patients.
publishDate 2010
dc.date.none.fl_str_mv 2010-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462010000300011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462010000300011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-44462010005000003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
dc.source.none.fl_str_mv Brazilian Journal of Psychiatry v.32 n.3 2010
reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
instname:Associação Brasileira de Psiquiatria (ABP)
instacron:ABP
instname_str Associação Brasileira de Psiquiatria (ABP)
instacron_str ABP
institution ABP
reponame_str Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
collection Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
repository.name.fl_str_mv Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)
repository.mail.fl_str_mv ||rbp@abpbrasil.org.br
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