Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients
Autor(a) principal: | |
---|---|
Data de Publicação: | 2010 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462010000300011 |
Resumo: | OBJECTIVE: Adenosine may play a role in the pathophysiology of schizophrenia, since it modulates the release of several neurotransmitters such as glutamate, dopamine, serotonin and acetylcholine, decreases neuronal activity by pos-synaptic hyperpolarization and inhibits dopaminergic activity. Adenosine deaminase participates in purine metabolism by converting adenosine into inosine. The most frequent functional polymorphism of adenosine deaminase (22G→A) (ADA1*2) exhibits 20-30% lower enzymatic activity in individuals with the G/A genotype than individuals with the G/G genotype. The aim of this study was to evaluate the ADA polymorphism 22G→A (ADA1*2) in schizophrenic patients and healthy controls. METHOD: The genotypes of the ADA 22G→A were identified with allele-specific PCR strategy in 152 schizophrenic patients and 111 healthy individuals. RESULTS: A significant decrease in the frequency of the G/A genotype was seen in schizophrenic patients (7/152 - 4.6%) relative to controls (13/111 - 11.7%, p = 0.032, OR = 2.6). CONCLUSION: These results suggest that the G/A genotype associated with low adenosine deaminase activity and, supposingly, with higher adenosine levels is less frequent among schizophrenic patients. |
id |
ABP-1_2c414ab4eb40b2a8ee950bda38b1c710 |
---|---|
oai_identifier_str |
oai:scielo:S1516-44462010000300011 |
network_acronym_str |
ABP-1 |
network_name_str |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
repository_id_str |
|
spelling |
Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patientsPolymorphism, restriction fragment lengthAdenosineAdenosine deaminaseSchizophreniaGene frequencyOBJECTIVE: Adenosine may play a role in the pathophysiology of schizophrenia, since it modulates the release of several neurotransmitters such as glutamate, dopamine, serotonin and acetylcholine, decreases neuronal activity by pos-synaptic hyperpolarization and inhibits dopaminergic activity. Adenosine deaminase participates in purine metabolism by converting adenosine into inosine. The most frequent functional polymorphism of adenosine deaminase (22G→A) (ADA1*2) exhibits 20-30% lower enzymatic activity in individuals with the G/A genotype than individuals with the G/G genotype. The aim of this study was to evaluate the ADA polymorphism 22G→A (ADA1*2) in schizophrenic patients and healthy controls. METHOD: The genotypes of the ADA 22G→A were identified with allele-specific PCR strategy in 152 schizophrenic patients and 111 healthy individuals. RESULTS: A significant decrease in the frequency of the G/A genotype was seen in schizophrenic patients (7/152 - 4.6%) relative to controls (13/111 - 11.7%, p = 0.032, OR = 2.6). CONCLUSION: These results suggest that the G/A genotype associated with low adenosine deaminase activity and, supposingly, with higher adenosine levels is less frequent among schizophrenic patients.Associação Brasileira de Psiquiatria2010-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462010000300011Brazilian Journal of Psychiatry v.32 n.3 2010reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABP10.1590/S1516-44462010005000003info:eu-repo/semantics/openAccessDutra,Gustavo PimentelOttoni,Gustavo L.Lara,Diogo R.Bogo,Maurício Reiseng2010-10-01T00:00:00Zoai:scielo:S1516-44462010000300011Revistahttp://www.bjp.org.br/ahead_of_print.asphttps://old.scielo.br/oai/scielo-oai.php||rbp@abpbrasil.org.br1809-452X1516-4446opendoar:2010-10-01T00:00Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)false |
dc.title.none.fl_str_mv |
Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients |
title |
Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients |
spellingShingle |
Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients Dutra,Gustavo Pimentel Polymorphism, restriction fragment length Adenosine Adenosine deaminase Schizophrenia Gene frequency |
title_short |
Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients |
title_full |
Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients |
title_fullStr |
Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients |
title_full_unstemmed |
Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients |
title_sort |
Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients |
author |
Dutra,Gustavo Pimentel |
author_facet |
Dutra,Gustavo Pimentel Ottoni,Gustavo L. Lara,Diogo R. Bogo,Maurício Reis |
author_role |
author |
author2 |
Ottoni,Gustavo L. Lara,Diogo R. Bogo,Maurício Reis |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Dutra,Gustavo Pimentel Ottoni,Gustavo L. Lara,Diogo R. Bogo,Maurício Reis |
dc.subject.por.fl_str_mv |
Polymorphism, restriction fragment length Adenosine Adenosine deaminase Schizophrenia Gene frequency |
topic |
Polymorphism, restriction fragment length Adenosine Adenosine deaminase Schizophrenia Gene frequency |
description |
OBJECTIVE: Adenosine may play a role in the pathophysiology of schizophrenia, since it modulates the release of several neurotransmitters such as glutamate, dopamine, serotonin and acetylcholine, decreases neuronal activity by pos-synaptic hyperpolarization and inhibits dopaminergic activity. Adenosine deaminase participates in purine metabolism by converting adenosine into inosine. The most frequent functional polymorphism of adenosine deaminase (22G→A) (ADA1*2) exhibits 20-30% lower enzymatic activity in individuals with the G/A genotype than individuals with the G/G genotype. The aim of this study was to evaluate the ADA polymorphism 22G→A (ADA1*2) in schizophrenic patients and healthy controls. METHOD: The genotypes of the ADA 22G→A were identified with allele-specific PCR strategy in 152 schizophrenic patients and 111 healthy individuals. RESULTS: A significant decrease in the frequency of the G/A genotype was seen in schizophrenic patients (7/152 - 4.6%) relative to controls (13/111 - 11.7%, p = 0.032, OR = 2.6). CONCLUSION: These results suggest that the G/A genotype associated with low adenosine deaminase activity and, supposingly, with higher adenosine levels is less frequent among schizophrenic patients. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462010000300011 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462010000300011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-44462010005000003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
dc.source.none.fl_str_mv |
Brazilian Journal of Psychiatry v.32 n.3 2010 reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online) instname:Associação Brasileira de Psiquiatria (ABP) instacron:ABP |
instname_str |
Associação Brasileira de Psiquiatria (ABP) |
instacron_str |
ABP |
institution |
ABP |
reponame_str |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
collection |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
repository.name.fl_str_mv |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP) |
repository.mail.fl_str_mv |
||rbp@abpbrasil.org.br |
_version_ |
1754212555130142720 |