The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description

Detalhes bibliográficos
Autor(a) principal: Hoexter,Marcelo Queiroz
Data de Publicação: 2009
Outros Autores: Shavitt,Roseli Gedanke, D'Alcante,Carina Chaubet, Cecconi,Janaina Philippi, Diniz,Juliana Belo, Belotto-Silva,Cristina, Hounie,Ana Gabriela, Borcato,Sonia, Moraes,Ivanil, Joaquim,Marines Alves, Cappi,Carolina, Sampaio,Aline Santos, Mathis,Maria Alice de, Batistuzzo,Marcelo Camargo, Lopes,Antonio Carlos, Rosa,Ana Carolina Ferreira, Muniz,Renan Kawano, Marques,Andrea Horvath, Santos,Luciana Cristina, Taub,Anita, Duran,Fábio Luís de Souza, Dougherty,Darin Dean, Busatto,Geraldo Filho, Bressan,Rodrigo Affonseca, Miguel,Euripedes Constantino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462009000400011
Resumo: OBJECTIVE: To describe a protocol that was based on an integrative neurobiological model of scientific investigation to better understand the pathophysiology of obsessive-compulsive disorder and to present the clinical and demographic characteristics of the sample. METHOD: A standardized research protocol that combines different methods of investigation (genetics, neuropsychology, morphometric magnetic resonance imaging and molecular neuroimaging of the dopamine transporter) obtained before and after treatment of drug-naïve adult obsessive-compulsive disorder patients submitted to a sequentially allocated 12-week clinical trial with a selective serotonin reuptake inhibitor (fluoxetine) and group cognitive-behavioral therapy. RESULTS: Fifty-two treatment-naïve obsessive-compulsive disorder patients entered the clinical trial (27 received fluoxetine and 25 received group cognitive-behavioral therapy). At baseline, 47 blood samples for genetic studies, 50 neuropsychological evaluations, 50 morphometrical magnetic resonance images and 48 TRODAT-1 single-photon emission computed tomography (SPECT) exams were obtained. After 12 weeks, 38 patients completed the protocol (fluoxetine = 20 and GCBT = 18). Thirty-eight neuropsychological evaluations, 31 morphometrical magnetic resonance images and 34 TRODAT-1 SPECT exams were obtained post-treatment. Forty-one healthy controls matched for age, gender, socioeconomic status, level of education and laterality were submitted to the same research procedures at baseline. CONCLUSION: The comprehensive treatment response protocol applied in this project allowing integration on genetic, neuropsychological, morphometrical and molecular imaging of the dopamine transporter data in drug-naïve patients has the potential to generate important original information on the neurobiology of obsessive-compulsive disorder, and at the same time be clinically meaningful.
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spelling The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample descriptionObsessive-compulsive disorderGeneticsCognitionImagingTreatment outcomeOBJECTIVE: To describe a protocol that was based on an integrative neurobiological model of scientific investigation to better understand the pathophysiology of obsessive-compulsive disorder and to present the clinical and demographic characteristics of the sample. METHOD: A standardized research protocol that combines different methods of investigation (genetics, neuropsychology, morphometric magnetic resonance imaging and molecular neuroimaging of the dopamine transporter) obtained before and after treatment of drug-naïve adult obsessive-compulsive disorder patients submitted to a sequentially allocated 12-week clinical trial with a selective serotonin reuptake inhibitor (fluoxetine) and group cognitive-behavioral therapy. RESULTS: Fifty-two treatment-naïve obsessive-compulsive disorder patients entered the clinical trial (27 received fluoxetine and 25 received group cognitive-behavioral therapy). At baseline, 47 blood samples for genetic studies, 50 neuropsychological evaluations, 50 morphometrical magnetic resonance images and 48 TRODAT-1 single-photon emission computed tomography (SPECT) exams were obtained. After 12 weeks, 38 patients completed the protocol (fluoxetine = 20 and GCBT = 18). Thirty-eight neuropsychological evaluations, 31 morphometrical magnetic resonance images and 34 TRODAT-1 SPECT exams were obtained post-treatment. Forty-one healthy controls matched for age, gender, socioeconomic status, level of education and laterality were submitted to the same research procedures at baseline. CONCLUSION: The comprehensive treatment response protocol applied in this project allowing integration on genetic, neuropsychological, morphometrical and molecular imaging of the dopamine transporter data in drug-naïve patients has the potential to generate important original information on the neurobiology of obsessive-compulsive disorder, and at the same time be clinically meaningful.Associação Brasileira de Psiquiatria2009-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462009000400011Brazilian Journal of Psychiatry v.31 n.4 2009reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABP10.1590/S1516-44462009000400011info:eu-repo/semantics/openAccessHoexter,Marcelo QueirozShavitt,Roseli GedankeD'Alcante,Carina ChaubetCecconi,Janaina PhilippiDiniz,Juliana BeloBelotto-Silva,CristinaHounie,Ana GabrielaBorcato,SoniaMoraes,IvanilJoaquim,Marines AlvesCappi,CarolinaSampaio,Aline SantosMathis,Maria Alice deBatistuzzo,Marcelo CamargoLopes,Antonio CarlosRosa,Ana Carolina FerreiraMuniz,Renan KawanoMarques,Andrea HorvathSantos,Luciana CristinaTaub,AnitaDuran,Fábio Luís de SouzaDougherty,Darin DeanBusatto,Geraldo FilhoBressan,Rodrigo AffonsecaMiguel,Euripedes Constantinoeng2010-01-22T00:00:00Zoai:scielo:S1516-44462009000400011Revistahttp://www.bjp.org.br/ahead_of_print.asphttps://old.scielo.br/oai/scielo-oai.php||rbp@abpbrasil.org.br1809-452X1516-4446opendoar:2010-01-22T00:00Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)false
dc.title.none.fl_str_mv The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description
title The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description
spellingShingle The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description
Hoexter,Marcelo Queiroz
Obsessive-compulsive disorder
Genetics
Cognition
Imaging
Treatment outcome
title_short The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description
title_full The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description
title_fullStr The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description
title_full_unstemmed The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description
title_sort The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description
author Hoexter,Marcelo Queiroz
author_facet Hoexter,Marcelo Queiroz
Shavitt,Roseli Gedanke
D'Alcante,Carina Chaubet
Cecconi,Janaina Philippi
Diniz,Juliana Belo
Belotto-Silva,Cristina
Hounie,Ana Gabriela
Borcato,Sonia
Moraes,Ivanil
Joaquim,Marines Alves
Cappi,Carolina
Sampaio,Aline Santos
Mathis,Maria Alice de
Batistuzzo,Marcelo Camargo
Lopes,Antonio Carlos
Rosa,Ana Carolina Ferreira
Muniz,Renan Kawano
Marques,Andrea Horvath
Santos,Luciana Cristina
Taub,Anita
Duran,Fábio Luís de Souza
Dougherty,Darin Dean
Busatto,Geraldo Filho
Bressan,Rodrigo Affonseca
Miguel,Euripedes Constantino
author_role author
author2 Shavitt,Roseli Gedanke
D'Alcante,Carina Chaubet
Cecconi,Janaina Philippi
Diniz,Juliana Belo
Belotto-Silva,Cristina
Hounie,Ana Gabriela
Borcato,Sonia
Moraes,Ivanil
Joaquim,Marines Alves
Cappi,Carolina
Sampaio,Aline Santos
Mathis,Maria Alice de
Batistuzzo,Marcelo Camargo
Lopes,Antonio Carlos
Rosa,Ana Carolina Ferreira
Muniz,Renan Kawano
Marques,Andrea Horvath
Santos,Luciana Cristina
Taub,Anita
Duran,Fábio Luís de Souza
Dougherty,Darin Dean
Busatto,Geraldo Filho
Bressan,Rodrigo Affonseca
Miguel,Euripedes Constantino
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Hoexter,Marcelo Queiroz
Shavitt,Roseli Gedanke
D'Alcante,Carina Chaubet
Cecconi,Janaina Philippi
Diniz,Juliana Belo
Belotto-Silva,Cristina
Hounie,Ana Gabriela
Borcato,Sonia
Moraes,Ivanil
Joaquim,Marines Alves
Cappi,Carolina
Sampaio,Aline Santos
Mathis,Maria Alice de
Batistuzzo,Marcelo Camargo
Lopes,Antonio Carlos
Rosa,Ana Carolina Ferreira
Muniz,Renan Kawano
Marques,Andrea Horvath
Santos,Luciana Cristina
Taub,Anita
Duran,Fábio Luís de Souza
Dougherty,Darin Dean
Busatto,Geraldo Filho
Bressan,Rodrigo Affonseca
Miguel,Euripedes Constantino
dc.subject.por.fl_str_mv Obsessive-compulsive disorder
Genetics
Cognition
Imaging
Treatment outcome
topic Obsessive-compulsive disorder
Genetics
Cognition
Imaging
Treatment outcome
description OBJECTIVE: To describe a protocol that was based on an integrative neurobiological model of scientific investigation to better understand the pathophysiology of obsessive-compulsive disorder and to present the clinical and demographic characteristics of the sample. METHOD: A standardized research protocol that combines different methods of investigation (genetics, neuropsychology, morphometric magnetic resonance imaging and molecular neuroimaging of the dopamine transporter) obtained before and after treatment of drug-naïve adult obsessive-compulsive disorder patients submitted to a sequentially allocated 12-week clinical trial with a selective serotonin reuptake inhibitor (fluoxetine) and group cognitive-behavioral therapy. RESULTS: Fifty-two treatment-naïve obsessive-compulsive disorder patients entered the clinical trial (27 received fluoxetine and 25 received group cognitive-behavioral therapy). At baseline, 47 blood samples for genetic studies, 50 neuropsychological evaluations, 50 morphometrical magnetic resonance images and 48 TRODAT-1 single-photon emission computed tomography (SPECT) exams were obtained. After 12 weeks, 38 patients completed the protocol (fluoxetine = 20 and GCBT = 18). Thirty-eight neuropsychological evaluations, 31 morphometrical magnetic resonance images and 34 TRODAT-1 SPECT exams were obtained post-treatment. Forty-one healthy controls matched for age, gender, socioeconomic status, level of education and laterality were submitted to the same research procedures at baseline. CONCLUSION: The comprehensive treatment response protocol applied in this project allowing integration on genetic, neuropsychological, morphometrical and molecular imaging of the dopamine transporter data in drug-naïve patients has the potential to generate important original information on the neurobiology of obsessive-compulsive disorder, and at the same time be clinically meaningful.
publishDate 2009
dc.date.none.fl_str_mv 2009-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462009000400011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462009000400011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-44462009000400011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
dc.source.none.fl_str_mv Brazilian Journal of Psychiatry v.31 n.4 2009
reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
instname:Associação Brasileira de Psiquiatria (ABP)
instacron:ABP
instname_str Associação Brasileira de Psiquiatria (ABP)
instacron_str ABP
institution ABP
reponame_str Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
collection Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
repository.name.fl_str_mv Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)
repository.mail.fl_str_mv ||rbp@abpbrasil.org.br
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