The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description
Autor(a) principal: | |
---|---|
Data de Publicação: | 2009 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462009000400011 |
Resumo: | OBJECTIVE: To describe a protocol that was based on an integrative neurobiological model of scientific investigation to better understand the pathophysiology of obsessive-compulsive disorder and to present the clinical and demographic characteristics of the sample. METHOD: A standardized research protocol that combines different methods of investigation (genetics, neuropsychology, morphometric magnetic resonance imaging and molecular neuroimaging of the dopamine transporter) obtained before and after treatment of drug-naïve adult obsessive-compulsive disorder patients submitted to a sequentially allocated 12-week clinical trial with a selective serotonin reuptake inhibitor (fluoxetine) and group cognitive-behavioral therapy. RESULTS: Fifty-two treatment-naïve obsessive-compulsive disorder patients entered the clinical trial (27 received fluoxetine and 25 received group cognitive-behavioral therapy). At baseline, 47 blood samples for genetic studies, 50 neuropsychological evaluations, 50 morphometrical magnetic resonance images and 48 TRODAT-1 single-photon emission computed tomography (SPECT) exams were obtained. After 12 weeks, 38 patients completed the protocol (fluoxetine = 20 and GCBT = 18). Thirty-eight neuropsychological evaluations, 31 morphometrical magnetic resonance images and 34 TRODAT-1 SPECT exams were obtained post-treatment. Forty-one healthy controls matched for age, gender, socioeconomic status, level of education and laterality were submitted to the same research procedures at baseline. CONCLUSION: The comprehensive treatment response protocol applied in this project allowing integration on genetic, neuropsychological, morphometrical and molecular imaging of the dopamine transporter data in drug-naïve patients has the potential to generate important original information on the neurobiology of obsessive-compulsive disorder, and at the same time be clinically meaningful. |
id |
ABP-1_4437ed8661bd2dc6d8c42712cd44b79c |
---|---|
oai_identifier_str |
oai:scielo:S1516-44462009000400011 |
network_acronym_str |
ABP-1 |
network_name_str |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
repository_id_str |
|
spelling |
The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample descriptionObsessive-compulsive disorderGeneticsCognitionImagingTreatment outcomeOBJECTIVE: To describe a protocol that was based on an integrative neurobiological model of scientific investigation to better understand the pathophysiology of obsessive-compulsive disorder and to present the clinical and demographic characteristics of the sample. METHOD: A standardized research protocol that combines different methods of investigation (genetics, neuropsychology, morphometric magnetic resonance imaging and molecular neuroimaging of the dopamine transporter) obtained before and after treatment of drug-naïve adult obsessive-compulsive disorder patients submitted to a sequentially allocated 12-week clinical trial with a selective serotonin reuptake inhibitor (fluoxetine) and group cognitive-behavioral therapy. RESULTS: Fifty-two treatment-naïve obsessive-compulsive disorder patients entered the clinical trial (27 received fluoxetine and 25 received group cognitive-behavioral therapy). At baseline, 47 blood samples for genetic studies, 50 neuropsychological evaluations, 50 morphometrical magnetic resonance images and 48 TRODAT-1 single-photon emission computed tomography (SPECT) exams were obtained. After 12 weeks, 38 patients completed the protocol (fluoxetine = 20 and GCBT = 18). Thirty-eight neuropsychological evaluations, 31 morphometrical magnetic resonance images and 34 TRODAT-1 SPECT exams were obtained post-treatment. Forty-one healthy controls matched for age, gender, socioeconomic status, level of education and laterality were submitted to the same research procedures at baseline. CONCLUSION: The comprehensive treatment response protocol applied in this project allowing integration on genetic, neuropsychological, morphometrical and molecular imaging of the dopamine transporter data in drug-naïve patients has the potential to generate important original information on the neurobiology of obsessive-compulsive disorder, and at the same time be clinically meaningful.Associação Brasileira de Psiquiatria2009-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462009000400011Brazilian Journal of Psychiatry v.31 n.4 2009reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABP10.1590/S1516-44462009000400011info:eu-repo/semantics/openAccessHoexter,Marcelo QueirozShavitt,Roseli GedankeD'Alcante,Carina ChaubetCecconi,Janaina PhilippiDiniz,Juliana BeloBelotto-Silva,CristinaHounie,Ana GabrielaBorcato,SoniaMoraes,IvanilJoaquim,Marines AlvesCappi,CarolinaSampaio,Aline SantosMathis,Maria Alice deBatistuzzo,Marcelo CamargoLopes,Antonio CarlosRosa,Ana Carolina FerreiraMuniz,Renan KawanoMarques,Andrea HorvathSantos,Luciana CristinaTaub,AnitaDuran,Fábio Luís de SouzaDougherty,Darin DeanBusatto,Geraldo FilhoBressan,Rodrigo AffonsecaMiguel,Euripedes Constantinoeng2010-01-22T00:00:00Zoai:scielo:S1516-44462009000400011Revistahttp://www.bjp.org.br/ahead_of_print.asphttps://old.scielo.br/oai/scielo-oai.php||rbp@abpbrasil.org.br1809-452X1516-4446opendoar:2010-01-22T00:00Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)false |
dc.title.none.fl_str_mv |
The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description |
title |
The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description |
spellingShingle |
The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description Hoexter,Marcelo Queiroz Obsessive-compulsive disorder Genetics Cognition Imaging Treatment outcome |
title_short |
The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description |
title_full |
The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description |
title_fullStr |
The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description |
title_full_unstemmed |
The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description |
title_sort |
The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description |
author |
Hoexter,Marcelo Queiroz |
author_facet |
Hoexter,Marcelo Queiroz Shavitt,Roseli Gedanke D'Alcante,Carina Chaubet Cecconi,Janaina Philippi Diniz,Juliana Belo Belotto-Silva,Cristina Hounie,Ana Gabriela Borcato,Sonia Moraes,Ivanil Joaquim,Marines Alves Cappi,Carolina Sampaio,Aline Santos Mathis,Maria Alice de Batistuzzo,Marcelo Camargo Lopes,Antonio Carlos Rosa,Ana Carolina Ferreira Muniz,Renan Kawano Marques,Andrea Horvath Santos,Luciana Cristina Taub,Anita Duran,Fábio Luís de Souza Dougherty,Darin Dean Busatto,Geraldo Filho Bressan,Rodrigo Affonseca Miguel,Euripedes Constantino |
author_role |
author |
author2 |
Shavitt,Roseli Gedanke D'Alcante,Carina Chaubet Cecconi,Janaina Philippi Diniz,Juliana Belo Belotto-Silva,Cristina Hounie,Ana Gabriela Borcato,Sonia Moraes,Ivanil Joaquim,Marines Alves Cappi,Carolina Sampaio,Aline Santos Mathis,Maria Alice de Batistuzzo,Marcelo Camargo Lopes,Antonio Carlos Rosa,Ana Carolina Ferreira Muniz,Renan Kawano Marques,Andrea Horvath Santos,Luciana Cristina Taub,Anita Duran,Fábio Luís de Souza Dougherty,Darin Dean Busatto,Geraldo Filho Bressan,Rodrigo Affonseca Miguel,Euripedes Constantino |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Hoexter,Marcelo Queiroz Shavitt,Roseli Gedanke D'Alcante,Carina Chaubet Cecconi,Janaina Philippi Diniz,Juliana Belo Belotto-Silva,Cristina Hounie,Ana Gabriela Borcato,Sonia Moraes,Ivanil Joaquim,Marines Alves Cappi,Carolina Sampaio,Aline Santos Mathis,Maria Alice de Batistuzzo,Marcelo Camargo Lopes,Antonio Carlos Rosa,Ana Carolina Ferreira Muniz,Renan Kawano Marques,Andrea Horvath Santos,Luciana Cristina Taub,Anita Duran,Fábio Luís de Souza Dougherty,Darin Dean Busatto,Geraldo Filho Bressan,Rodrigo Affonseca Miguel,Euripedes Constantino |
dc.subject.por.fl_str_mv |
Obsessive-compulsive disorder Genetics Cognition Imaging Treatment outcome |
topic |
Obsessive-compulsive disorder Genetics Cognition Imaging Treatment outcome |
description |
OBJECTIVE: To describe a protocol that was based on an integrative neurobiological model of scientific investigation to better understand the pathophysiology of obsessive-compulsive disorder and to present the clinical and demographic characteristics of the sample. METHOD: A standardized research protocol that combines different methods of investigation (genetics, neuropsychology, morphometric magnetic resonance imaging and molecular neuroimaging of the dopamine transporter) obtained before and after treatment of drug-naïve adult obsessive-compulsive disorder patients submitted to a sequentially allocated 12-week clinical trial with a selective serotonin reuptake inhibitor (fluoxetine) and group cognitive-behavioral therapy. RESULTS: Fifty-two treatment-naïve obsessive-compulsive disorder patients entered the clinical trial (27 received fluoxetine and 25 received group cognitive-behavioral therapy). At baseline, 47 blood samples for genetic studies, 50 neuropsychological evaluations, 50 morphometrical magnetic resonance images and 48 TRODAT-1 single-photon emission computed tomography (SPECT) exams were obtained. After 12 weeks, 38 patients completed the protocol (fluoxetine = 20 and GCBT = 18). Thirty-eight neuropsychological evaluations, 31 morphometrical magnetic resonance images and 34 TRODAT-1 SPECT exams were obtained post-treatment. Forty-one healthy controls matched for age, gender, socioeconomic status, level of education and laterality were submitted to the same research procedures at baseline. CONCLUSION: The comprehensive treatment response protocol applied in this project allowing integration on genetic, neuropsychological, morphometrical and molecular imaging of the dopamine transporter data in drug-naïve patients has the potential to generate important original information on the neurobiology of obsessive-compulsive disorder, and at the same time be clinically meaningful. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462009000400011 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462009000400011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-44462009000400011 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
dc.source.none.fl_str_mv |
Brazilian Journal of Psychiatry v.31 n.4 2009 reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online) instname:Associação Brasileira de Psiquiatria (ABP) instacron:ABP |
instname_str |
Associação Brasileira de Psiquiatria (ABP) |
instacron_str |
ABP |
institution |
ABP |
reponame_str |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
collection |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
repository.name.fl_str_mv |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP) |
repository.mail.fl_str_mv |
||rbp@abpbrasil.org.br |
_version_ |
1754212554701275136 |