Transtorno obsessivo-compulsivo resistente: conceito e estratégias de tratamento
Autor(a) principal: | |
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Data de Publicação: | 2001 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462001000600016 |
Resumo: | Despite the fact that majority of OCD patients responds to conventional treatments, about 40% remain symptomatic after appropriate trials with serotonin uptake inhibitors (SRIs) or behavioral therapy. A patient is considered treatment-resistant after failing to respond to three pharmacological trials with SRIs as well as to behavior therapy. When all somatic strategies have been tried, including augmentation with other medications, and the patient remains symptomatic, he or she is considered treatment refractory. The concepts of resistance and refractoriness are briefly revised, and the current augmentation strategies, as well as non-pharmacological approaches such as neurosurgery and transcranial magnetic stimulation, are addressed in this paper. Finally, issues of predictive response factors, pharmacogenetics, and the pathophysiology of resistant cases are suggested as targets for further researches. |
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Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
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Transtorno obsessivo-compulsivo resistente: conceito e estratégias de tratamentoObsessive-compulsive disorderTreatmentDespite the fact that majority of OCD patients responds to conventional treatments, about 40% remain symptomatic after appropriate trials with serotonin uptake inhibitors (SRIs) or behavioral therapy. A patient is considered treatment-resistant after failing to respond to three pharmacological trials with SRIs as well as to behavior therapy. When all somatic strategies have been tried, including augmentation with other medications, and the patient remains symptomatic, he or she is considered treatment refractory. The concepts of resistance and refractoriness are briefly revised, and the current augmentation strategies, as well as non-pharmacological approaches such as neurosurgery and transcranial magnetic stimulation, are addressed in this paper. Finally, issues of predictive response factors, pharmacogenetics, and the pathophysiology of resistant cases are suggested as targets for further researches.Associação Brasileira de Psiquiatria2001-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462001000600016Brazilian Journal of Psychiatry v.23 suppl.2 2001reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABP10.1590/S1516-44462001000600016info:eu-repo/semantics/openAccessShavitt,Roseli GFerrão,Ygor ABravo,Maria ClaudiaBelotto,CristinaLopes Junior,AdemirMiguel,Eurípedes Cpor2001-12-11T00:00:00Zoai:scielo:S1516-44462001000600016Revistahttp://www.bjp.org.br/ahead_of_print.asphttps://old.scielo.br/oai/scielo-oai.php||rbp@abpbrasil.org.br1809-452X1516-4446opendoar:2001-12-11T00:00Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)false |
dc.title.none.fl_str_mv |
Transtorno obsessivo-compulsivo resistente: conceito e estratégias de tratamento |
title |
Transtorno obsessivo-compulsivo resistente: conceito e estratégias de tratamento |
spellingShingle |
Transtorno obsessivo-compulsivo resistente: conceito e estratégias de tratamento Shavitt,Roseli G Obsessive-compulsive disorder Treatment |
title_short |
Transtorno obsessivo-compulsivo resistente: conceito e estratégias de tratamento |
title_full |
Transtorno obsessivo-compulsivo resistente: conceito e estratégias de tratamento |
title_fullStr |
Transtorno obsessivo-compulsivo resistente: conceito e estratégias de tratamento |
title_full_unstemmed |
Transtorno obsessivo-compulsivo resistente: conceito e estratégias de tratamento |
title_sort |
Transtorno obsessivo-compulsivo resistente: conceito e estratégias de tratamento |
author |
Shavitt,Roseli G |
author_facet |
Shavitt,Roseli G Ferrão,Ygor A Bravo,Maria Claudia Belotto,Cristina Lopes Junior,Ademir Miguel,Eurípedes C |
author_role |
author |
author2 |
Ferrão,Ygor A Bravo,Maria Claudia Belotto,Cristina Lopes Junior,Ademir Miguel,Eurípedes C |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Shavitt,Roseli G Ferrão,Ygor A Bravo,Maria Claudia Belotto,Cristina Lopes Junior,Ademir Miguel,Eurípedes C |
dc.subject.por.fl_str_mv |
Obsessive-compulsive disorder Treatment |
topic |
Obsessive-compulsive disorder Treatment |
description |
Despite the fact that majority of OCD patients responds to conventional treatments, about 40% remain symptomatic after appropriate trials with serotonin uptake inhibitors (SRIs) or behavioral therapy. A patient is considered treatment-resistant after failing to respond to three pharmacological trials with SRIs as well as to behavior therapy. When all somatic strategies have been tried, including augmentation with other medications, and the patient remains symptomatic, he or she is considered treatment refractory. The concepts of resistance and refractoriness are briefly revised, and the current augmentation strategies, as well as non-pharmacological approaches such as neurosurgery and transcranial magnetic stimulation, are addressed in this paper. Finally, issues of predictive response factors, pharmacogenetics, and the pathophysiology of resistant cases are suggested as targets for further researches. |
publishDate |
2001 |
dc.date.none.fl_str_mv |
2001-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462001000600016 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462001000600016 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
10.1590/S1516-44462001000600016 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
dc.source.none.fl_str_mv |
Brazilian Journal of Psychiatry v.23 suppl.2 2001 reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online) instname:Associação Brasileira de Psiquiatria (ABP) instacron:ABP |
instname_str |
Associação Brasileira de Psiquiatria (ABP) |
instacron_str |
ABP |
institution |
ABP |
reponame_str |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
collection |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
repository.name.fl_str_mv |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP) |
repository.mail.fl_str_mv |
||rbp@abpbrasil.org.br |
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1754212552066203648 |