N-acetylcysteine for major depressive episodes in bipolar disorder
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462011000400011 |
Resumo: | OBJECTIVE: In this report, we aimed to evaluate the effect of add-on N-acetylcysteine (NAC) on depressive symptoms and functional outcomes in bipolar disorder. To that end, we conducted a secondary analysis of all patients meeting full criteria for a depressive episode in a placebo controlled trial of adjunctive NAC for bipolar disorder. METHOD: Twenty-four week randomised clinical trial comparing adjunctive NAC and placebo in individuals with bipolar disorder experiencing major depressive episodes. Symptomatic and functional outcome data were collected over the study period. RESULTS: Seventeen participants were available for this report. Very large effect sizes in favor of NAC were found for depressive symptoms and functional outcomes at endpoint. Eight of the ten participants on NAC had a treatment response at endpoint; the same was true for only one of the seven participants allocated to placebo. DISCUSSION: These results indicate that adjunctive NAC may be useful for major depressive episodes in bipolar disorder. Further studies designed to confirm this hypothesis are necessary. |
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Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
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N-acetylcysteine for major depressive episodes in bipolar disorderBipolar disorderDepressionAcetylcysteineAntioxidantsOxidative stressOBJECTIVE: In this report, we aimed to evaluate the effect of add-on N-acetylcysteine (NAC) on depressive symptoms and functional outcomes in bipolar disorder. To that end, we conducted a secondary analysis of all patients meeting full criteria for a depressive episode in a placebo controlled trial of adjunctive NAC for bipolar disorder. METHOD: Twenty-four week randomised clinical trial comparing adjunctive NAC and placebo in individuals with bipolar disorder experiencing major depressive episodes. Symptomatic and functional outcome data were collected over the study period. RESULTS: Seventeen participants were available for this report. Very large effect sizes in favor of NAC were found for depressive symptoms and functional outcomes at endpoint. Eight of the ten participants on NAC had a treatment response at endpoint; the same was true for only one of the seven participants allocated to placebo. DISCUSSION: These results indicate that adjunctive NAC may be useful for major depressive episodes in bipolar disorder. Further studies designed to confirm this hypothesis are necessary.Associação Brasileira de Psiquiatria2011-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462011000400011Brazilian Journal of Psychiatry v.33 n.4 2011reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABP10.1590/S1516-44462011000400011info:eu-repo/semantics/openAccessMagalhães,Pedro VDean,Olívia MBush,Ashley ICopolov,David LMalhi,Gin SKohlmann,KristyJeavons,SusanSchapkaitz,IanAnderson-Hunt,MurrayBerk,Michaeleng2013-04-05T00:00:00Zoai:scielo:S1516-44462011000400011Revistahttp://www.bjp.org.br/ahead_of_print.asphttps://old.scielo.br/oai/scielo-oai.php||rbp@abpbrasil.org.br1809-452X1516-4446opendoar:2013-04-05T00:00Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)false |
dc.title.none.fl_str_mv |
N-acetylcysteine for major depressive episodes in bipolar disorder |
title |
N-acetylcysteine for major depressive episodes in bipolar disorder |
spellingShingle |
N-acetylcysteine for major depressive episodes in bipolar disorder Magalhães,Pedro V Bipolar disorder Depression Acetylcysteine Antioxidants Oxidative stress |
title_short |
N-acetylcysteine for major depressive episodes in bipolar disorder |
title_full |
N-acetylcysteine for major depressive episodes in bipolar disorder |
title_fullStr |
N-acetylcysteine for major depressive episodes in bipolar disorder |
title_full_unstemmed |
N-acetylcysteine for major depressive episodes in bipolar disorder |
title_sort |
N-acetylcysteine for major depressive episodes in bipolar disorder |
author |
Magalhães,Pedro V |
author_facet |
Magalhães,Pedro V Dean,Olívia M Bush,Ashley I Copolov,David L Malhi,Gin S Kohlmann,Kristy Jeavons,Susan Schapkaitz,Ian Anderson-Hunt,Murray Berk,Michael |
author_role |
author |
author2 |
Dean,Olívia M Bush,Ashley I Copolov,David L Malhi,Gin S Kohlmann,Kristy Jeavons,Susan Schapkaitz,Ian Anderson-Hunt,Murray Berk,Michael |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Magalhães,Pedro V Dean,Olívia M Bush,Ashley I Copolov,David L Malhi,Gin S Kohlmann,Kristy Jeavons,Susan Schapkaitz,Ian Anderson-Hunt,Murray Berk,Michael |
dc.subject.por.fl_str_mv |
Bipolar disorder Depression Acetylcysteine Antioxidants Oxidative stress |
topic |
Bipolar disorder Depression Acetylcysteine Antioxidants Oxidative stress |
description |
OBJECTIVE: In this report, we aimed to evaluate the effect of add-on N-acetylcysteine (NAC) on depressive symptoms and functional outcomes in bipolar disorder. To that end, we conducted a secondary analysis of all patients meeting full criteria for a depressive episode in a placebo controlled trial of adjunctive NAC for bipolar disorder. METHOD: Twenty-four week randomised clinical trial comparing adjunctive NAC and placebo in individuals with bipolar disorder experiencing major depressive episodes. Symptomatic and functional outcome data were collected over the study period. RESULTS: Seventeen participants were available for this report. Very large effect sizes in favor of NAC were found for depressive symptoms and functional outcomes at endpoint. Eight of the ten participants on NAC had a treatment response at endpoint; the same was true for only one of the seven participants allocated to placebo. DISCUSSION: These results indicate that adjunctive NAC may be useful for major depressive episodes in bipolar disorder. Further studies designed to confirm this hypothesis are necessary. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462011000400011 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462011000400011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-44462011000400011 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
dc.source.none.fl_str_mv |
Brazilian Journal of Psychiatry v.33 n.4 2011 reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online) instname:Associação Brasileira de Psiquiatria (ABP) instacron:ABP |
instname_str |
Associação Brasileira de Psiquiatria (ABP) |
instacron_str |
ABP |
institution |
ABP |
reponame_str |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
collection |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
repository.name.fl_str_mv |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP) |
repository.mail.fl_str_mv |
||rbp@abpbrasil.org.br |
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1754212555520212992 |