Increased oxidative stress as a mechanism for decreased BDNF levels in acute manic episodes

• Autor(a) principal: Kapczinski,Flávio
• Data de Publicação: 2008
• Outros Autores: Frey,Benício N, Andreazza,Ana C, Kauer-Sant'Anna,Márcia, Cunha,Ângelo B M, Post,Robert M
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462008000300011
• topic: Bipolar disorder; Brain-derived neurotrophic factor; Mania Depression; Oxidative stress; Thiobarbituric acid reactive substances

OBJECTIVE AND METHOD: There is a growing amount of data indicating that alterations in brain-derived neurotrophic factor and increased oxidative stress may play a role in the pathophysiology of bipolar disorder. In light of recent evidence demonstrating that brain-derived neurotrophic factor levels are decreased in situations of increased oxidative stress, we have examined the correlation between serum thiobarbituric acid reactive substances, a measure of lipid peroxidation, and serum brain-derived neurotrophic factor levels in bipolar disorder patients during acute mania and in healthy controls. RESULTS: Serum thiobarbituric acid reactive substances and brain-derived neurotrophic factor levels were negatively correlated in bipolar disorder patients (r = -0.56; p = 0.001), whereas no significant correlation was observed in the control group.. CONCLUSION: These results suggest that alterations in oxidative status may be mechanistically associated with abnormal low levels of brain-derived neurotrophic factor observed in individuals with bipolar disorder.