Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000200157 |
Resumo: | Objective: To evaluate serum levels of different biomarkers associated with cardiovascular disease in patients with bipolar disorder (BD). Patients were prospectively evaluated in two separate instances: during acute mania and after remission of manic symptoms. All measurements were compared with those of healthy controls. Methods: The study included 30 patients with BD and 30 healthy controls, matched for gender and age. Biochemical parameters evaluated included homocysteine (Hcy), folic acid, vitamin B12, ferritin, creatine kinase (CK) and C-reactive protein (CRP). Results: Hcy levels were significantly higher in the BD patients, both during mania and after achieving euthymia. When Hcy was adjusted for body mass index, there was no significant difference between patients and controls. Ferritin was the only marker that showed a significant decrease during mania when compared to both euthymic patients and controls. There were no significant differences for folate, vitamin B12, CK and CRP. Conclusions: These findings do not show an association between alterations of markers of cardiovascular risk during manic episodes. Further studies are necessary to determine factors and mechanisms associated with cardiovascular risk in patients with BD. |
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Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
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Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorderHomocysteineferritinbipolar disordercardiovascular disease Objective: To evaluate serum levels of different biomarkers associated with cardiovascular disease in patients with bipolar disorder (BD). Patients were prospectively evaluated in two separate instances: during acute mania and after remission of manic symptoms. All measurements were compared with those of healthy controls. Methods: The study included 30 patients with BD and 30 healthy controls, matched for gender and age. Biochemical parameters evaluated included homocysteine (Hcy), folic acid, vitamin B12, ferritin, creatine kinase (CK) and C-reactive protein (CRP). Results: Hcy levels were significantly higher in the BD patients, both during mania and after achieving euthymia. When Hcy was adjusted for body mass index, there was no significant difference between patients and controls. Ferritin was the only marker that showed a significant decrease during mania when compared to both euthymic patients and controls. There were no significant differences for folate, vitamin B12, CK and CRP. Conclusions: These findings do not show an association between alterations of markers of cardiovascular risk during manic episodes. Further studies are necessary to determine factors and mechanisms associated with cardiovascular risk in patients with BD. Associação Brasileira de Psiquiatria2013-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000200157Brazilian Journal of Psychiatry v.35 n.2 2013reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABP10.1590/1516-4446-2012-0797info:eu-repo/semantics/openAccessChiarani,FábriaTramontina,Juliana FernandesCeresér,Keila MariaKunz,MaurícioPaim,LeonardoVargas,Carmen ReglaSitta,AngelaMachado,Sérgio PintoWyse,Angela Terezinha de SouzaKapczinski,Flávio Pereiraeng2015-03-20T00:00:00Zoai:scielo:S1516-44462013000200157Revistahttp://www.bjp.org.br/ahead_of_print.asphttps://old.scielo.br/oai/scielo-oai.php||rbp@abpbrasil.org.br1809-452X1516-4446opendoar:2015-03-20T00:00Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)false |
dc.title.none.fl_str_mv |
Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder |
title |
Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder |
spellingShingle |
Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder Chiarani,Fábria Homocysteine ferritin bipolar disorder cardiovascular disease |
title_short |
Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder |
title_full |
Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder |
title_fullStr |
Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder |
title_full_unstemmed |
Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder |
title_sort |
Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder |
author |
Chiarani,Fábria |
author_facet |
Chiarani,Fábria Tramontina,Juliana Fernandes Ceresér,Keila Maria Kunz,Maurício Paim,Leonardo Vargas,Carmen Regla Sitta,Angela Machado,Sérgio Pinto Wyse,Angela Terezinha de Souza Kapczinski,Flávio Pereira |
author_role |
author |
author2 |
Tramontina,Juliana Fernandes Ceresér,Keila Maria Kunz,Maurício Paim,Leonardo Vargas,Carmen Regla Sitta,Angela Machado,Sérgio Pinto Wyse,Angela Terezinha de Souza Kapczinski,Flávio Pereira |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Chiarani,Fábria Tramontina,Juliana Fernandes Ceresér,Keila Maria Kunz,Maurício Paim,Leonardo Vargas,Carmen Regla Sitta,Angela Machado,Sérgio Pinto Wyse,Angela Terezinha de Souza Kapczinski,Flávio Pereira |
dc.subject.por.fl_str_mv |
Homocysteine ferritin bipolar disorder cardiovascular disease |
topic |
Homocysteine ferritin bipolar disorder cardiovascular disease |
description |
Objective: To evaluate serum levels of different biomarkers associated with cardiovascular disease in patients with bipolar disorder (BD). Patients were prospectively evaluated in two separate instances: during acute mania and after remission of manic symptoms. All measurements were compared with those of healthy controls. Methods: The study included 30 patients with BD and 30 healthy controls, matched for gender and age. Biochemical parameters evaluated included homocysteine (Hcy), folic acid, vitamin B12, ferritin, creatine kinase (CK) and C-reactive protein (CRP). Results: Hcy levels were significantly higher in the BD patients, both during mania and after achieving euthymia. When Hcy was adjusted for body mass index, there was no significant difference between patients and controls. Ferritin was the only marker that showed a significant decrease during mania when compared to both euthymic patients and controls. There were no significant differences for folate, vitamin B12, CK and CRP. Conclusions: These findings do not show an association between alterations of markers of cardiovascular risk during manic episodes. Further studies are necessary to determine factors and mechanisms associated with cardiovascular risk in patients with BD. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000200157 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000200157 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1516-4446-2012-0797 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
dc.source.none.fl_str_mv |
Brazilian Journal of Psychiatry v.35 n.2 2013 reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online) instname:Associação Brasileira de Psiquiatria (ABP) instacron:ABP |
instname_str |
Associação Brasileira de Psiquiatria (ABP) |
instacron_str |
ABP |
institution |
ABP |
reponame_str |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
collection |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
repository.name.fl_str_mv |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP) |
repository.mail.fl_str_mv |
||rbp@abpbrasil.org.br |
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1754212555979489280 |