Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls

Detalhes bibliográficos
Autor(a) principal: Vasconcelos-Moreno,Mirela P.
Data de Publicação: 2016
Outros Autores: Bücker,Joana, Bürke,Kelen P., Czepielewski,Leticia, Santos,Barbara T., Fijtman,Adam, Passos,Ives C., Kunz,Mauricio, Bonnín,Caterina del Mar, Vieta,Eduard, Kapczinski,Flavio, Rosa,Adriane R., Kauer-Sant’Anna,Marcia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016000400275
Resumo: Objective: To assess cognitive performance and psychosocial functioning in patients with bipolar disorder (BD), in unaffected siblings, and in healthy controls. Methods: Subjects were patients with BD (n=36), unaffected siblings (n=35), and healthy controls (n=44). Psychosocial functioning was accessed using the Functioning Assessment Short Test (FAST). A sub-group of patients with BD (n=21), unaffected siblings (n=14), and healthy controls (n=22) also underwent a battery of neuropsychological tests: California Verbal Learning Test (CVLT), Stroop Color and Word Test, and Wisconsin Card Sorting Test (WCST). Clinical and sociodemographic characteristics were analyzed using one-way analysis of variance or the chi-square test; multivariate analysis of covariance was used to examine differences in neuropsychological variables. Results: Patients with BD showed higher FAST total scores (23.90±11.35) than healthy controls (5.86±5.47; p < 0.001) and siblings (12.60±11.83; p 0.001). Siblings and healthy controls also showed statistically significant differences in FAST total scores (p = 0.008). Patients performed worse than healthy controls on all CVLT sub-tests (p < 0.030) and in the number of correctly completed categories on WCST (p = 0.030). Siblings did not differ from healthy controls in cognitive tests. Conclusion: Unaffected siblings of patients with BD may show poorer functional performance compared to healthy controls. FAST scores may contribute to the development of markers of vulnerability and endophenotypic traits in at-risk populations.
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spelling Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controlsBipolar disordersiblingsfunctional impairmentcognitionendophenotype Objective: To assess cognitive performance and psychosocial functioning in patients with bipolar disorder (BD), in unaffected siblings, and in healthy controls. Methods: Subjects were patients with BD (n=36), unaffected siblings (n=35), and healthy controls (n=44). Psychosocial functioning was accessed using the Functioning Assessment Short Test (FAST). A sub-group of patients with BD (n=21), unaffected siblings (n=14), and healthy controls (n=22) also underwent a battery of neuropsychological tests: California Verbal Learning Test (CVLT), Stroop Color and Word Test, and Wisconsin Card Sorting Test (WCST). Clinical and sociodemographic characteristics were analyzed using one-way analysis of variance or the chi-square test; multivariate analysis of covariance was used to examine differences in neuropsychological variables. Results: Patients with BD showed higher FAST total scores (23.90±11.35) than healthy controls (5.86±5.47; p < 0.001) and siblings (12.60±11.83; p 0.001). Siblings and healthy controls also showed statistically significant differences in FAST total scores (p = 0.008). Patients performed worse than healthy controls on all CVLT sub-tests (p < 0.030) and in the number of correctly completed categories on WCST (p = 0.030). Siblings did not differ from healthy controls in cognitive tests. Conclusion: Unaffected siblings of patients with BD may show poorer functional performance compared to healthy controls. FAST scores may contribute to the development of markers of vulnerability and endophenotypic traits in at-risk populations.Associação Brasileira de Psiquiatria2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016000400275Brazilian Journal of Psychiatry v.38 n.4 2016reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABP10.1590/1516-4446-2015-1868info:eu-repo/semantics/openAccessVasconcelos-Moreno,Mirela P.Bücker,JoanaBürke,Kelen P.Czepielewski,LeticiaSantos,Barbara T.Fijtman,AdamPassos,Ives C.Kunz,MauricioBonnín,Caterina del MarVieta,EduardKapczinski,FlavioRosa,Adriane R.Kauer-Sant’Anna,Marciaeng2016-11-01T00:00:00Zoai:scielo:S1516-44462016000400275Revistahttp://www.bjp.org.br/ahead_of_print.asphttps://old.scielo.br/oai/scielo-oai.php||rbp@abpbrasil.org.br1809-452X1516-4446opendoar:2016-11-01T00:00Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)false
dc.title.none.fl_str_mv Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls
title Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls
spellingShingle Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls
Vasconcelos-Moreno,Mirela P.
Bipolar disorder
siblings
functional impairment
cognition
endophenotype
title_short Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls
title_full Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls
title_fullStr Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls
title_full_unstemmed Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls
title_sort Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls
author Vasconcelos-Moreno,Mirela P.
author_facet Vasconcelos-Moreno,Mirela P.
Bücker,Joana
Bürke,Kelen P.
Czepielewski,Leticia
Santos,Barbara T.
Fijtman,Adam
Passos,Ives C.
Kunz,Mauricio
Bonnín,Caterina del Mar
Vieta,Eduard
Kapczinski,Flavio
Rosa,Adriane R.
Kauer-Sant’Anna,Marcia
author_role author
author2 Bücker,Joana
Bürke,Kelen P.
Czepielewski,Leticia
Santos,Barbara T.
Fijtman,Adam
Passos,Ives C.
Kunz,Mauricio
Bonnín,Caterina del Mar
Vieta,Eduard
Kapczinski,Flavio
Rosa,Adriane R.
Kauer-Sant’Anna,Marcia
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vasconcelos-Moreno,Mirela P.
Bücker,Joana
Bürke,Kelen P.
Czepielewski,Leticia
Santos,Barbara T.
Fijtman,Adam
Passos,Ives C.
Kunz,Mauricio
Bonnín,Caterina del Mar
Vieta,Eduard
Kapczinski,Flavio
Rosa,Adriane R.
Kauer-Sant’Anna,Marcia
dc.subject.por.fl_str_mv Bipolar disorder
siblings
functional impairment
cognition
endophenotype
topic Bipolar disorder
siblings
functional impairment
cognition
endophenotype
description Objective: To assess cognitive performance and psychosocial functioning in patients with bipolar disorder (BD), in unaffected siblings, and in healthy controls. Methods: Subjects were patients with BD (n=36), unaffected siblings (n=35), and healthy controls (n=44). Psychosocial functioning was accessed using the Functioning Assessment Short Test (FAST). A sub-group of patients with BD (n=21), unaffected siblings (n=14), and healthy controls (n=22) also underwent a battery of neuropsychological tests: California Verbal Learning Test (CVLT), Stroop Color and Word Test, and Wisconsin Card Sorting Test (WCST). Clinical and sociodemographic characteristics were analyzed using one-way analysis of variance or the chi-square test; multivariate analysis of covariance was used to examine differences in neuropsychological variables. Results: Patients with BD showed higher FAST total scores (23.90±11.35) than healthy controls (5.86±5.47; p < 0.001) and siblings (12.60±11.83; p 0.001). Siblings and healthy controls also showed statistically significant differences in FAST total scores (p = 0.008). Patients performed worse than healthy controls on all CVLT sub-tests (p < 0.030) and in the number of correctly completed categories on WCST (p = 0.030). Siblings did not differ from healthy controls in cognitive tests. Conclusion: Unaffected siblings of patients with BD may show poorer functional performance compared to healthy controls. FAST scores may contribute to the development of markers of vulnerability and endophenotypic traits in at-risk populations.
publishDate 2016
dc.date.none.fl_str_mv 2016-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016000400275
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016000400275
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1516-4446-2015-1868
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
dc.source.none.fl_str_mv Brazilian Journal of Psychiatry v.38 n.4 2016
reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
instname:Associação Brasileira de Psiquiatria (ABP)
instacron:ABP
instname_str Associação Brasileira de Psiquiatria (ABP)
instacron_str ABP
institution ABP
reponame_str Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
collection Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
repository.name.fl_str_mv Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)
repository.mail.fl_str_mv ||rbp@abpbrasil.org.br
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