Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016000300247 |
Resumo: | Objective: To evaluate the antidepressant effects of exercise in older adults, using randomized controlled trial (RCT) data. Methods: We conducted a meta-analysis of exercise in older adults, addressing limitations of previous works. RCTs of exercise interventions in older people with depression (≥ 60 years) comparing exercise vs. control were eligible. A random-effects meta-analysis calculating the standardized mean difference (SMD) (95% confidence interval [95%CI]), meta-regressions, and trim, fill, and fail-safe number analyses were conducted. Results: Eight RCTs were included, representing 138 participants in exercise arms and 129 controls. Exercise had a large and significant effect on depression (SMD = -0.90 [95%CI -0.29 to -1.51]), with a fail-safe number of 71 studies. Significant effects were found for 1) mixed aerobic and anaerobic interventions, 2) at moderate intensity, 3) that were group-based, 4) that utilized mixed supervised and unsupervised formats, and 5) in people without other clinical comorbidities. Conclusion: Adjusting for publication bias increased the beneficial effects of exercise in three subgroup analysis, suggesting that previous meta-analyses have underestimated the benefits of exercise due to publication bias. We advocate that exercise be considered as a routine component of the management of depression in older adults. |
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Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
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Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication biasExercisedepressionolder adultspublication biasmeta-analysis Objective: To evaluate the antidepressant effects of exercise in older adults, using randomized controlled trial (RCT) data. Methods: We conducted a meta-analysis of exercise in older adults, addressing limitations of previous works. RCTs of exercise interventions in older people with depression (≥ 60 years) comparing exercise vs. control were eligible. A random-effects meta-analysis calculating the standardized mean difference (SMD) (95% confidence interval [95%CI]), meta-regressions, and trim, fill, and fail-safe number analyses were conducted. Results: Eight RCTs were included, representing 138 participants in exercise arms and 129 controls. Exercise had a large and significant effect on depression (SMD = -0.90 [95%CI -0.29 to -1.51]), with a fail-safe number of 71 studies. Significant effects were found for 1) mixed aerobic and anaerobic interventions, 2) at moderate intensity, 3) that were group-based, 4) that utilized mixed supervised and unsupervised formats, and 5) in people without other clinical comorbidities. Conclusion: Adjusting for publication bias increased the beneficial effects of exercise in three subgroup analysis, suggesting that previous meta-analyses have underestimated the benefits of exercise due to publication bias. We advocate that exercise be considered as a routine component of the management of depression in older adults.Associação Brasileira de Psiquiatria2016-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016000300247Brazilian Journal of Psychiatry v.38 n.3 2016reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABP10.1590/1516-4446-2016-1915info:eu-repo/semantics/openAccessSchuch,Felipe B.Vancampfort,DavyRosenbaum,SimonRichards,JustinWard,Philip B.Veronese,NicolaSolmi,MarcoCadore,Eduardo L.Stubbs,Brendoneng2016-08-23T00:00:00Zoai:scielo:S1516-44462016000300247Revistahttp://www.bjp.org.br/ahead_of_print.asphttps://old.scielo.br/oai/scielo-oai.php||rbp@abpbrasil.org.br1809-452X1516-4446opendoar:2016-08-23T00:00Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)false |
dc.title.none.fl_str_mv |
Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias |
title |
Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias |
spellingShingle |
Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias Schuch,Felipe B. Exercise depression older adults publication bias meta-analysis |
title_short |
Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias |
title_full |
Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias |
title_fullStr |
Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias |
title_full_unstemmed |
Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias |
title_sort |
Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias |
author |
Schuch,Felipe B. |
author_facet |
Schuch,Felipe B. Vancampfort,Davy Rosenbaum,Simon Richards,Justin Ward,Philip B. Veronese,Nicola Solmi,Marco Cadore,Eduardo L. Stubbs,Brendon |
author_role |
author |
author2 |
Vancampfort,Davy Rosenbaum,Simon Richards,Justin Ward,Philip B. Veronese,Nicola Solmi,Marco Cadore,Eduardo L. Stubbs,Brendon |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Schuch,Felipe B. Vancampfort,Davy Rosenbaum,Simon Richards,Justin Ward,Philip B. Veronese,Nicola Solmi,Marco Cadore,Eduardo L. Stubbs,Brendon |
dc.subject.por.fl_str_mv |
Exercise depression older adults publication bias meta-analysis |
topic |
Exercise depression older adults publication bias meta-analysis |
description |
Objective: To evaluate the antidepressant effects of exercise in older adults, using randomized controlled trial (RCT) data. Methods: We conducted a meta-analysis of exercise in older adults, addressing limitations of previous works. RCTs of exercise interventions in older people with depression (≥ 60 years) comparing exercise vs. control were eligible. A random-effects meta-analysis calculating the standardized mean difference (SMD) (95% confidence interval [95%CI]), meta-regressions, and trim, fill, and fail-safe number analyses were conducted. Results: Eight RCTs were included, representing 138 participants in exercise arms and 129 controls. Exercise had a large and significant effect on depression (SMD = -0.90 [95%CI -0.29 to -1.51]), with a fail-safe number of 71 studies. Significant effects were found for 1) mixed aerobic and anaerobic interventions, 2) at moderate intensity, 3) that were group-based, 4) that utilized mixed supervised and unsupervised formats, and 5) in people without other clinical comorbidities. Conclusion: Adjusting for publication bias increased the beneficial effects of exercise in three subgroup analysis, suggesting that previous meta-analyses have underestimated the benefits of exercise due to publication bias. We advocate that exercise be considered as a routine component of the management of depression in older adults. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016000300247 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016000300247 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1516-4446-2016-1915 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
dc.source.none.fl_str_mv |
Brazilian Journal of Psychiatry v.38 n.3 2016 reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online) instname:Associação Brasileira de Psiquiatria (ABP) instacron:ABP |
instname_str |
Associação Brasileira de Psiquiatria (ABP) |
instacron_str |
ABP |
institution |
ABP |
reponame_str |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
collection |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
repository.name.fl_str_mv |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP) |
repository.mail.fl_str_mv |
||rbp@abpbrasil.org.br |
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1754212557313277952 |