Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias

Detalhes bibliográficos
Autor(a) principal: Schuch,Felipe B.
Data de Publicação: 2016
Outros Autores: Vancampfort,Davy, Rosenbaum,Simon, Richards,Justin, Ward,Philip B., Veronese,Nicola, Solmi,Marco, Cadore,Eduardo L., Stubbs,Brendon
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016000300247
Resumo: Objective: To evaluate the antidepressant effects of exercise in older adults, using randomized controlled trial (RCT) data. Methods: We conducted a meta-analysis of exercise in older adults, addressing limitations of previous works. RCTs of exercise interventions in older people with depression (≥ 60 years) comparing exercise vs. control were eligible. A random-effects meta-analysis calculating the standardized mean difference (SMD) (95% confidence interval [95%CI]), meta-regressions, and trim, fill, and fail-safe number analyses were conducted. Results: Eight RCTs were included, representing 138 participants in exercise arms and 129 controls. Exercise had a large and significant effect on depression (SMD = -0.90 [95%CI -0.29 to -1.51]), with a fail-safe number of 71 studies. Significant effects were found for 1) mixed aerobic and anaerobic interventions, 2) at moderate intensity, 3) that were group-based, 4) that utilized mixed supervised and unsupervised formats, and 5) in people without other clinical comorbidities. Conclusion: Adjusting for publication bias increased the beneficial effects of exercise in three subgroup analysis, suggesting that previous meta-analyses have underestimated the benefits of exercise due to publication bias. We advocate that exercise be considered as a routine component of the management of depression in older adults.
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spelling Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication biasExercisedepressionolder adultspublication biasmeta-analysis Objective: To evaluate the antidepressant effects of exercise in older adults, using randomized controlled trial (RCT) data. Methods: We conducted a meta-analysis of exercise in older adults, addressing limitations of previous works. RCTs of exercise interventions in older people with depression (≥ 60 years) comparing exercise vs. control were eligible. A random-effects meta-analysis calculating the standardized mean difference (SMD) (95% confidence interval [95%CI]), meta-regressions, and trim, fill, and fail-safe number analyses were conducted. Results: Eight RCTs were included, representing 138 participants in exercise arms and 129 controls. Exercise had a large and significant effect on depression (SMD = -0.90 [95%CI -0.29 to -1.51]), with a fail-safe number of 71 studies. Significant effects were found for 1) mixed aerobic and anaerobic interventions, 2) at moderate intensity, 3) that were group-based, 4) that utilized mixed supervised and unsupervised formats, and 5) in people without other clinical comorbidities. Conclusion: Adjusting for publication bias increased the beneficial effects of exercise in three subgroup analysis, suggesting that previous meta-analyses have underestimated the benefits of exercise due to publication bias. We advocate that exercise be considered as a routine component of the management of depression in older adults.Associação Brasileira de Psiquiatria2016-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016000300247Brazilian Journal of Psychiatry v.38 n.3 2016reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABP10.1590/1516-4446-2016-1915info:eu-repo/semantics/openAccessSchuch,Felipe B.Vancampfort,DavyRosenbaum,SimonRichards,JustinWard,Philip B.Veronese,NicolaSolmi,MarcoCadore,Eduardo L.Stubbs,Brendoneng2016-08-23T00:00:00Zoai:scielo:S1516-44462016000300247Revistahttp://www.bjp.org.br/ahead_of_print.asphttps://old.scielo.br/oai/scielo-oai.php||rbp@abpbrasil.org.br1809-452X1516-4446opendoar:2016-08-23T00:00Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)false
dc.title.none.fl_str_mv Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias
title Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias
spellingShingle Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias
Schuch,Felipe B.
Exercise
depression
older adults
publication bias
meta-analysis
title_short Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias
title_full Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias
title_fullStr Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias
title_full_unstemmed Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias
title_sort Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias
author Schuch,Felipe B.
author_facet Schuch,Felipe B.
Vancampfort,Davy
Rosenbaum,Simon
Richards,Justin
Ward,Philip B.
Veronese,Nicola
Solmi,Marco
Cadore,Eduardo L.
Stubbs,Brendon
author_role author
author2 Vancampfort,Davy
Rosenbaum,Simon
Richards,Justin
Ward,Philip B.
Veronese,Nicola
Solmi,Marco
Cadore,Eduardo L.
Stubbs,Brendon
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Schuch,Felipe B.
Vancampfort,Davy
Rosenbaum,Simon
Richards,Justin
Ward,Philip B.
Veronese,Nicola
Solmi,Marco
Cadore,Eduardo L.
Stubbs,Brendon
dc.subject.por.fl_str_mv Exercise
depression
older adults
publication bias
meta-analysis
topic Exercise
depression
older adults
publication bias
meta-analysis
description Objective: To evaluate the antidepressant effects of exercise in older adults, using randomized controlled trial (RCT) data. Methods: We conducted a meta-analysis of exercise in older adults, addressing limitations of previous works. RCTs of exercise interventions in older people with depression (≥ 60 years) comparing exercise vs. control were eligible. A random-effects meta-analysis calculating the standardized mean difference (SMD) (95% confidence interval [95%CI]), meta-regressions, and trim, fill, and fail-safe number analyses were conducted. Results: Eight RCTs were included, representing 138 participants in exercise arms and 129 controls. Exercise had a large and significant effect on depression (SMD = -0.90 [95%CI -0.29 to -1.51]), with a fail-safe number of 71 studies. Significant effects were found for 1) mixed aerobic and anaerobic interventions, 2) at moderate intensity, 3) that were group-based, 4) that utilized mixed supervised and unsupervised formats, and 5) in people without other clinical comorbidities. Conclusion: Adjusting for publication bias increased the beneficial effects of exercise in three subgroup analysis, suggesting that previous meta-analyses have underestimated the benefits of exercise due to publication bias. We advocate that exercise be considered as a routine component of the management of depression in older adults.
publishDate 2016
dc.date.none.fl_str_mv 2016-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016000300247
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016000300247
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1516-4446-2016-1915
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
dc.source.none.fl_str_mv Brazilian Journal of Psychiatry v.38 n.3 2016
reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
instname:Associação Brasileira de Psiquiatria (ABP)
instacron:ABP
instname_str Associação Brasileira de Psiquiatria (ABP)
instacron_str ABP
institution ABP
reponame_str Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
collection Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
repository.name.fl_str_mv Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)
repository.mail.fl_str_mv ||rbp@abpbrasil.org.br
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