The effect of 5-HT2a/2c receptor agonist microinjected into central amygdaloid nucleus and median preoptic area on maternal aggressive behavior in rats
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462006000200011 |
Resumo: | OBJECTIVE: Much evidence supports the hypothesis that 5-hydroxytryptamine (5-HT) activation is related to the inhibition of aggression. We examined potentially pro- and anti-aggressive effects of the 5-HT2A/2C receptor agonist on specific brain sites. METHOD: Female Wistar rats on the 7th day postpartum were microinjected with the selective 5-HT2A/2C receptor agonist, alpha-methyl-5-hydroxytryptamine maleate (0.2 to 1.0 µg/0.2 µl) into the central amygdaloid nucleus and median preoptic nucleus. For each brain area studied, the frequency of the behaviors: locomotion, social investigation, lateral threat, attacks (frontal and lateral), and biting the intruder were compared among the various treatments by an Analysis of Variance, followed when appropriate, by Tukey's test. RESULTS: Microinjection of the selective 5-HT2A/2C receptor agonist, a-methyl-5-hydroxytryptamine maleate into central amygdaloid nucleus increased maternal aggression in the absence of concurrent changes in non-aggressive behavior. By contrast, microinjection of the selective 5-HT2A/2C receptor agonist at several dilutions into the median preoptic nucleusdid not alter aggressive behavior. CONCLUSIONS: The current and earlier data with pro- and anti-aggressive effects of the 5-HT2a/2c receptor agonist, when microinjected into the median preoptic nucleus relative to the central amygdaloid nucleus, medial septum and periaqueductal grey area in female rats point to functionally separate serotonin receptor populations in the amygdaloid-septal-hypothalamic and periaqueductal gray matter areas controlling aggressive behavior. It is possible that amygdaloid 5-HT2a/2c receptors may increase aggressive behavior in lactating females as a result of changes in fear. |
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Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
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The effect of 5-HT2a/2c receptor agonist microinjected into central amygdaloid nucleus and median preoptic area on maternal aggressive behavior in ratsSerotonin agonistBehavior, animalRats, WistarMaternal behaviorViolenceOBJECTIVE: Much evidence supports the hypothesis that 5-hydroxytryptamine (5-HT) activation is related to the inhibition of aggression. We examined potentially pro- and anti-aggressive effects of the 5-HT2A/2C receptor agonist on specific brain sites. METHOD: Female Wistar rats on the 7th day postpartum were microinjected with the selective 5-HT2A/2C receptor agonist, alpha-methyl-5-hydroxytryptamine maleate (0.2 to 1.0 µg/0.2 µl) into the central amygdaloid nucleus and median preoptic nucleus. For each brain area studied, the frequency of the behaviors: locomotion, social investigation, lateral threat, attacks (frontal and lateral), and biting the intruder were compared among the various treatments by an Analysis of Variance, followed when appropriate, by Tukey's test. RESULTS: Microinjection of the selective 5-HT2A/2C receptor agonist, a-methyl-5-hydroxytryptamine maleate into central amygdaloid nucleus increased maternal aggression in the absence of concurrent changes in non-aggressive behavior. By contrast, microinjection of the selective 5-HT2A/2C receptor agonist at several dilutions into the median preoptic nucleusdid not alter aggressive behavior. CONCLUSIONS: The current and earlier data with pro- and anti-aggressive effects of the 5-HT2a/2c receptor agonist, when microinjected into the median preoptic nucleus relative to the central amygdaloid nucleus, medial septum and periaqueductal grey area in female rats point to functionally separate serotonin receptor populations in the amygdaloid-septal-hypothalamic and periaqueductal gray matter areas controlling aggressive behavior. It is possible that amygdaloid 5-HT2a/2c receptors may increase aggressive behavior in lactating females as a result of changes in fear.Associação Brasileira de Psiquiatria2006-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462006000200011Brazilian Journal of Psychiatry v.28 n.2 2006reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABP10.1590/S1516-44462006000200011info:eu-repo/semantics/openAccessAlmeida,Rosa Maria Martins deGiovenardi,MarciaSilva,Simone Perroni daOliveira,Verônica Paz deStein,Dirson Joãoeng2006-06-26T00:00:00Zoai:scielo:S1516-44462006000200011Revistahttp://www.bjp.org.br/ahead_of_print.asphttps://old.scielo.br/oai/scielo-oai.php||rbp@abpbrasil.org.br1809-452X1516-4446opendoar:2006-06-26T00:00Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)false |
dc.title.none.fl_str_mv |
The effect of 5-HT2a/2c receptor agonist microinjected into central amygdaloid nucleus and median preoptic area on maternal aggressive behavior in rats |
title |
The effect of 5-HT2a/2c receptor agonist microinjected into central amygdaloid nucleus and median preoptic area on maternal aggressive behavior in rats |
spellingShingle |
The effect of 5-HT2a/2c receptor agonist microinjected into central amygdaloid nucleus and median preoptic area on maternal aggressive behavior in rats Almeida,Rosa Maria Martins de Serotonin agonist Behavior, animal Rats, Wistar Maternal behavior Violence |
title_short |
The effect of 5-HT2a/2c receptor agonist microinjected into central amygdaloid nucleus and median preoptic area on maternal aggressive behavior in rats |
title_full |
The effect of 5-HT2a/2c receptor agonist microinjected into central amygdaloid nucleus and median preoptic area on maternal aggressive behavior in rats |
title_fullStr |
The effect of 5-HT2a/2c receptor agonist microinjected into central amygdaloid nucleus and median preoptic area on maternal aggressive behavior in rats |
title_full_unstemmed |
The effect of 5-HT2a/2c receptor agonist microinjected into central amygdaloid nucleus and median preoptic area on maternal aggressive behavior in rats |
title_sort |
The effect of 5-HT2a/2c receptor agonist microinjected into central amygdaloid nucleus and median preoptic area on maternal aggressive behavior in rats |
author |
Almeida,Rosa Maria Martins de |
author_facet |
Almeida,Rosa Maria Martins de Giovenardi,Marcia Silva,Simone Perroni da Oliveira,Verônica Paz de Stein,Dirson João |
author_role |
author |
author2 |
Giovenardi,Marcia Silva,Simone Perroni da Oliveira,Verônica Paz de Stein,Dirson João |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Almeida,Rosa Maria Martins de Giovenardi,Marcia Silva,Simone Perroni da Oliveira,Verônica Paz de Stein,Dirson João |
dc.subject.por.fl_str_mv |
Serotonin agonist Behavior, animal Rats, Wistar Maternal behavior Violence |
topic |
Serotonin agonist Behavior, animal Rats, Wistar Maternal behavior Violence |
description |
OBJECTIVE: Much evidence supports the hypothesis that 5-hydroxytryptamine (5-HT) activation is related to the inhibition of aggression. We examined potentially pro- and anti-aggressive effects of the 5-HT2A/2C receptor agonist on specific brain sites. METHOD: Female Wistar rats on the 7th day postpartum were microinjected with the selective 5-HT2A/2C receptor agonist, alpha-methyl-5-hydroxytryptamine maleate (0.2 to 1.0 µg/0.2 µl) into the central amygdaloid nucleus and median preoptic nucleus. For each brain area studied, the frequency of the behaviors: locomotion, social investigation, lateral threat, attacks (frontal and lateral), and biting the intruder were compared among the various treatments by an Analysis of Variance, followed when appropriate, by Tukey's test. RESULTS: Microinjection of the selective 5-HT2A/2C receptor agonist, a-methyl-5-hydroxytryptamine maleate into central amygdaloid nucleus increased maternal aggression in the absence of concurrent changes in non-aggressive behavior. By contrast, microinjection of the selective 5-HT2A/2C receptor agonist at several dilutions into the median preoptic nucleusdid not alter aggressive behavior. CONCLUSIONS: The current and earlier data with pro- and anti-aggressive effects of the 5-HT2a/2c receptor agonist, when microinjected into the median preoptic nucleus relative to the central amygdaloid nucleus, medial septum and periaqueductal grey area in female rats point to functionally separate serotonin receptor populations in the amygdaloid-septal-hypothalamic and periaqueductal gray matter areas controlling aggressive behavior. It is possible that amygdaloid 5-HT2a/2c receptors may increase aggressive behavior in lactating females as a result of changes in fear. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462006000200011 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462006000200011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-44462006000200011 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
dc.source.none.fl_str_mv |
Brazilian Journal of Psychiatry v.28 n.2 2006 reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online) instname:Associação Brasileira de Psiquiatria (ABP) instacron:ABP |
instname_str |
Associação Brasileira de Psiquiatria (ABP) |
instacron_str |
ABP |
institution |
ABP |
reponame_str |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
collection |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
repository.name.fl_str_mv |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP) |
repository.mail.fl_str_mv |
||rbp@abpbrasil.org.br |
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