Rhabdomyolysis secondary to zolpidem-induced seizures

Detalhes bibliográficos
Autor(a) principal: Carvalho, Maxwell Silva
Data de Publicação: 2023
Outros Autores: Weber, César Augusto Trinta
Tipo de documento: Artigo
Idioma: por
Título da fonte: Debates em Psiquiatria (Online)
Texto Completo: https://revistardp.org.br/revista/article/view/764
Resumo: Introduction: Rhabdomyolysis is a condition in which muscle destruction and necrosis occurs. Of varied etiology, it may be associated with convulsive crises. Zolpidem is a non-benzodiazepine sedative and hypnotic agent that under conditions of abuse and frequency can cause seizures. Case Report: Male, 26-year-old man was taken to the emergency room at a general hospital due to anxiety, where he had episodes of seizures. The condition progresses to rhabdomyolysis. History of zolpidem abuse. Discussion: High doses of zolpidem alter the selective agonism in the benzodiazepine-1 receptor and the abrupt withdrawal of the medication can lead to seizures with evolution, in severe cases, to rhabdomyolysis. Conclusions: Self-medication and abusive use of substances such as zolpidem have the potential to cause tolerance and dependence and may lead to life-threatening clinical conditions.
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spelling Rhabdomyolysis secondary to zolpidem-induced seizuresRabdomiólisis secundaria a convulsiones inducidas por zolpidemRabdomiólise secundária a convulsões induzidas por zolpidemconvulsõesmau uso de medicamentos de venda sob prescriçãorabdomiólisetranstornos relacionados ao uso de substânciaszolpidemseizuresdrug misuserhabdomyolysissubstance-related disorderszolpidemconvulsionesabuso de medicamentosrabdomiolisistrastornos relacionados com sustanciaszolpidemIntroduction: Rhabdomyolysis is a condition in which muscle destruction and necrosis occurs. Of varied etiology, it may be associated with convulsive crises. Zolpidem is a non-benzodiazepine sedative and hypnotic agent that under conditions of abuse and frequency can cause seizures. Case Report: Male, 26-year-old man was taken to the emergency room at a general hospital due to anxiety, where he had episodes of seizures. The condition progresses to rhabdomyolysis. History of zolpidem abuse. Discussion: High doses of zolpidem alter the selective agonism in the benzodiazepine-1 receptor and the abrupt withdrawal of the medication can lead to seizures with evolution, in severe cases, to rhabdomyolysis. Conclusions: Self-medication and abusive use of substances such as zolpidem have the potential to cause tolerance and dependence and may lead to life-threatening clinical conditions.Introducción: La rabdomiólisis es una condición en la que se produce destrucción y necrosis muscular. De variada etiología, puede asociarse a crisis convulsivas. Zolpidem es un agente sedante e hipnótico no benzodiacepínico que, en condiciones de abuso y frecuencia, puede causar convulsiones. Caso Clínico: Un hombre de 26 años fue llevado a urgencias de un hospital general por ansiedad, donde presentó episodios de convulsiones. La condición progresa a rabdomiolisis. Antecedentes de abuso de zolpidem. Discusión: Dosis altas de zolpidem alteran el agonismo selectivo en el receptor de la benzodiazepina-1 y la retirada brusca de la medicación puede dar lugar a convulsiones con evolución, en casos graves, a rabdomiólisis. Conclusiones: La automedicación y el uso abusivo de sustancias como el zolpidem tienen el potencial de causar tolerancia y dependencia y pueden conducir a condiciones clínicas potencialmente mortales.Introdução: Rabdomiólise é uma condição em que ocorre a destruição e necrose muscular. De etiologia variada, pode estar associada a crises convulsivas. O zolpidem é um agente sedativo e hipnótico não benzodiazepínico que sob condições de abuso e frequência pode ocasionar crises convulsivas. Relato de Caso: Homem, 26 anos, foi levado à emergência de hospital geral por ansiedade, onde apresentou episódios de crises convulsivas. Quadro evolui para rabdomiólise. História de abuso de zolpidem. Discussão: Altas doses de zolpidem alteram o agonismo seletivo no receptor benzodiazepina-1 e a retirada abrupta da medicação podem levar a crises convulsivas com evolução, em quadros graves, para rabdomiólise. Conclusões: A automedicação, e o uso abusivo de substâncias como zolpidem, apresentam potencial de causar tolerância e dependência podendo levar a quadros clínicos com risco a vida.Associação Brasileira de Psiquiatria2023-05-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado pelos paresapplication/pdfhttps://revistardp.org.br/revista/article/view/76410.25118/2763-9037.2023.v13.764Debates in Psychiatry; Vol. 13 (2023); 1-12Debates em Psiquiatria; Vol. 13 (2023); 1-12Debates em Psiquiatria; v. 13 (2023); 1-122763-90372236-918Xreponame:Debates em Psiquiatria (Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABPporhttps://revistardp.org.br/revista/article/view/764/604Copyright (c) 2023 Maxwell Silva Carvalho, César Augusto Trinta Weberhttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessCarvalho, Maxwell SilvaWeber, César Augusto Trinta2024-01-21T09:29:07Zoai:ojs.emnuvens.com.br:article/764Revistahttps://revistardp.org.br/revista/oaiPUBhttps://revistardp.org.br/revista/oairdp@abp.org.br2763-90372236-918Xopendoar:2024-01-21T09:29:07Debates em Psiquiatria (Online) - Associação Brasileira de Psiquiatria (ABP)false
dc.title.none.fl_str_mv Rhabdomyolysis secondary to zolpidem-induced seizures
Rabdomiólisis secundaria a convulsiones inducidas por zolpidem
Rabdomiólise secundária a convulsões induzidas por zolpidem
title Rhabdomyolysis secondary to zolpidem-induced seizures
spellingShingle Rhabdomyolysis secondary to zolpidem-induced seizures
Carvalho, Maxwell Silva
convulsões
mau uso de medicamentos de venda sob prescrição
rabdomiólise
transtornos relacionados ao uso de substâncias
zolpidem
seizures
drug misuse
rhabdomyolysis
substance-related disorders
zolpidem
convulsiones
abuso de medicamentos
rabdomiolisis
trastornos relacionados com sustancias
zolpidem
title_short Rhabdomyolysis secondary to zolpidem-induced seizures
title_full Rhabdomyolysis secondary to zolpidem-induced seizures
title_fullStr Rhabdomyolysis secondary to zolpidem-induced seizures
title_full_unstemmed Rhabdomyolysis secondary to zolpidem-induced seizures
title_sort Rhabdomyolysis secondary to zolpidem-induced seizures
author Carvalho, Maxwell Silva
author_facet Carvalho, Maxwell Silva
Weber, César Augusto Trinta
author_role author
author2 Weber, César Augusto Trinta
author2_role author
dc.contributor.author.fl_str_mv Carvalho, Maxwell Silva
Weber, César Augusto Trinta
dc.subject.por.fl_str_mv convulsões
mau uso de medicamentos de venda sob prescrição
rabdomiólise
transtornos relacionados ao uso de substâncias
zolpidem
seizures
drug misuse
rhabdomyolysis
substance-related disorders
zolpidem
convulsiones
abuso de medicamentos
rabdomiolisis
trastornos relacionados com sustancias
zolpidem
topic convulsões
mau uso de medicamentos de venda sob prescrição
rabdomiólise
transtornos relacionados ao uso de substâncias
zolpidem
seizures
drug misuse
rhabdomyolysis
substance-related disorders
zolpidem
convulsiones
abuso de medicamentos
rabdomiolisis
trastornos relacionados com sustancias
zolpidem
description Introduction: Rhabdomyolysis is a condition in which muscle destruction and necrosis occurs. Of varied etiology, it may be associated with convulsive crises. Zolpidem is a non-benzodiazepine sedative and hypnotic agent that under conditions of abuse and frequency can cause seizures. Case Report: Male, 26-year-old man was taken to the emergency room at a general hospital due to anxiety, where he had episodes of seizures. The condition progresses to rhabdomyolysis. History of zolpidem abuse. Discussion: High doses of zolpidem alter the selective agonism in the benzodiazepine-1 receptor and the abrupt withdrawal of the medication can lead to seizures with evolution, in severe cases, to rhabdomyolysis. Conclusions: Self-medication and abusive use of substances such as zolpidem have the potential to cause tolerance and dependence and may lead to life-threatening clinical conditions.
publishDate 2023
dc.date.none.fl_str_mv 2023-05-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistardp.org.br/revista/article/view/764
10.25118/2763-9037.2023.v13.764
url https://revistardp.org.br/revista/article/view/764
identifier_str_mv 10.25118/2763-9037.2023.v13.764
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistardp.org.br/revista/article/view/764/604
dc.rights.driver.fl_str_mv Copyright (c) 2023 Maxwell Silva Carvalho, César Augusto Trinta Weber
https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Maxwell Silva Carvalho, César Augusto Trinta Weber
https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
dc.source.none.fl_str_mv Debates in Psychiatry; Vol. 13 (2023); 1-12
Debates em Psiquiatria; Vol. 13 (2023); 1-12
Debates em Psiquiatria; v. 13 (2023); 1-12
2763-9037
2236-918X
reponame:Debates em Psiquiatria (Online)
instname:Associação Brasileira de Psiquiatria (ABP)
instacron:ABP
instname_str Associação Brasileira de Psiquiatria (ABP)
instacron_str ABP
institution ABP
reponame_str Debates em Psiquiatria (Online)
collection Debates em Psiquiatria (Online)
repository.name.fl_str_mv Debates em Psiquiatria (Online) - Associação Brasileira de Psiquiatria (ABP)
repository.mail.fl_str_mv rdp@abp.org.br
_version_ 1796798366095507456

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