The use of clozapine and other antipsychotics for treatment-resistant schizophrenia at the brazilian psychosocial care centers in Joao Pessoa, PB, Brazil

Detalhes bibliográficos
Autor(a) principal: Nascimento, Gabriela Jorge do
Data de Publicação: 2023
Outros Autores: Medeiros, Heydrich Lopes Virgulino de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Debates em Psiquiatria (Online)
Texto Completo: https://revistardp.org.br/revista/article/view/511
Resumo: Introduction: Although Clozapine is the drug recommended for treatment-resistant schizophrenia (TRS), it is underprescribed. Objectives: To analyze the pattern of clozapine prescription and use of other antipsychotics for patients with treatment-resistant schizophrenia in community mental health centers in Joao Pessoa. Methods: Antipsychotic prescriptions and medical records of patients with schizophrenia were reviewed. The psychiatrists of the services completed a survey on the difficulties associated with prescribing clozapine. Results: Among 381 patients with schizophrenia, 102 (26.8%) met the TRS criteria. Forty of the TRS patients (39.2%) were in polypharmacy; 25 in atypical antipsychotic monotherapy (24.6%), 3 with typical antipsychotic monotherapy (3%), and only 34 were using clozapine (33.3%). An important obstacle is the logistics required for blood counts routine. Conclusion: The most TRS patients (66.7%) was prescribed non-clozapine treatment, mostly polypharmacy, at the Brazilian Psychosocial Care Centers in Joao Pessoa.
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spelling The use of clozapine and other antipsychotics for treatment-resistant schizophrenia at the brazilian psychosocial care centers in Joao Pessoa, PB, BrazilEl uso de clozapina y otros antipsicóticos en esquizofrenia resistente en centros de atención psicosocial de João Pessoa, PB, BrasilO uso de clozapina e outros antipsicóticos em esquizofrenia resistente nos centros de atenção psicossocial de João Pessoa, PB, Brasilesquizofrenia resistenteclozapinaantipsicóticosresistant schizophreniaclozapineantipsychoticsesquizofrenia resistenteclozapinaantipsicóticosIntroduction: Although Clozapine is the drug recommended for treatment-resistant schizophrenia (TRS), it is underprescribed. Objectives: To analyze the pattern of clozapine prescription and use of other antipsychotics for patients with treatment-resistant schizophrenia in community mental health centers in Joao Pessoa. Methods: Antipsychotic prescriptions and medical records of patients with schizophrenia were reviewed. The psychiatrists of the services completed a survey on the difficulties associated with prescribing clozapine. Results: Among 381 patients with schizophrenia, 102 (26.8%) met the TRS criteria. Forty of the TRS patients (39.2%) were in polypharmacy; 25 in atypical antipsychotic monotherapy (24.6%), 3 with typical antipsychotic monotherapy (3%), and only 34 were using clozapine (33.3%). An important obstacle is the logistics required for blood counts routine. Conclusion: The most TRS patients (66.7%) was prescribed non-clozapine treatment, mostly polypharmacy, at the Brazilian Psychosocial Care Centers in Joao Pessoa.Introducción: La clozapina es el antipsicótico preconizado para el tratamiento de la esquizofrenia resistente (ERT). Aun así, son comunes investigaciones que evidencian la prescripción de clozapina por debajo de lo deseable. Objetivo: Avaluar el patrón de prescripción de clozapina y otros antipsicóticos en pacientes con ERT en los Centros de Atención Psicosocial (CAPS) de João Pessoa. Método: Prescripciones de antipsicóticos y registros de consultas médicas de los pacientes con esquizofrenia fueron revisados a través de prontuarios médicos a fin de verificar a aquellos que cumplían con criterios para una enfermedad refractaria. Los psiquiatras de los servicios respondieron un cuestionario sobre las dificultades de prescripción de la clozapina. Resultados: De 381 pacientes con esquizofrenia, 102 (26,8%) cumplían el criterio de ERT. Cuarenta de los pacientes ERT (39,2%) estaban en polifarmacia; 25 en monoterapia con atípicos (24,6%), 3 en monoterapia con típicos (3%) y apenas 34 en uso de clozapina (33,3%). Conclusión: La mayor parte de los pacientes ERT (66,7%) estaban bajo el uso de otro tratamiento, la mayoría polifarmacia, en detrimento de la clozapina en los CAPS de João Pessoa.Introdução: Embora a clozapina seja a droga preconizada para esquizofrenia resistente ao tratamento (ERT), ela é subprescrita. Objetivo: Avaliar o padrão de prescrição de clozapina e outros antipsicóticos em pacientes com ERT nos Centros de Atenção Psicossocial (CAPS) de João Pessoa. Método: Prescrições de antipsicóticos e registros de consultas médicas dos pacientes com esquizofrenia foram revisados através de prontuários médicos a fim de verificar aqueles que preenchiam critério para ERT. Os psiquiatras dos serviços responderam um questionário sobre as dificuldades de prescrição da clozapina. Resultados: De 381 pacientes com esquizofrenia, 102 (26,8%) preencheram critério de ERT. Quarenta dos pacientes com ERT (39,2%) estavam em uso de associação de antipsicóticos; 25 em monoterapia com antipsicóticos atípicos (24,6%), 3 em monoterapia com antipsicóticos típicos (3%) e apenas 34 em uso de clozapina (33,3%). Um obstáculo importante é a logística necessária para a realização de hemogramas.  Conclusão: A maior parte dos pacientes com ERT (66,7%) estavam sob uso de outro tratamento, a maioria fazendo associação entre antipsicóticos, em detrimento da clozapina nos CAPS de João Pessoa.Associação Brasileira de Psiquiatria2023-07-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-ReviewedRevisado por ParesAvaliado Pelos Paresapplication/pdfhttps://revistardp.org.br/revista/article/view/51110.25118/2763-9037.2023.v13.511Debates in Psychiatry; Vol. 13 (2023); 1-18Debates em Psiquiatria; Vol. 13 (2023); 1-18Debates em Psiquiatria; v. 13 (2023); 1-182763-90372236-918Xreponame:Debates em Psiquiatria (Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABPporhttps://revistardp.org.br/revista/article/view/511/731Copyright (c) 2023 Gabriela Jorge do Nascimento, Heydrich Lopes Virgulino de Medeiroshttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessNascimento, Gabriela Jorge doMedeiros, Heydrich Lopes Virgulino de2024-01-21T09:29:03Zoai:ojs.emnuvens.com.br:article/511Revistahttps://revistardp.org.br/revista/oaiPUBhttps://revistardp.org.br/revista/oairdp@abp.org.br2763-90372236-918Xopendoar:2024-01-21T09:29:03Debates em Psiquiatria (Online) - Associação Brasileira de Psiquiatria (ABP)false
dc.title.none.fl_str_mv The use of clozapine and other antipsychotics for treatment-resistant schizophrenia at the brazilian psychosocial care centers in Joao Pessoa, PB, Brazil
El uso de clozapina y otros antipsicóticos en esquizofrenia resistente en centros de atención psicosocial de João Pessoa, PB, Brasil
O uso de clozapina e outros antipsicóticos em esquizofrenia resistente nos centros de atenção psicossocial de João Pessoa, PB, Brasil
title The use of clozapine and other antipsychotics for treatment-resistant schizophrenia at the brazilian psychosocial care centers in Joao Pessoa, PB, Brazil
spellingShingle The use of clozapine and other antipsychotics for treatment-resistant schizophrenia at the brazilian psychosocial care centers in Joao Pessoa, PB, Brazil
Nascimento, Gabriela Jorge do
esquizofrenia resistente
clozapina
antipsicóticos
resistant schizophrenia
clozapine
antipsychotics
esquizofrenia resistente
clozapina
antipsicóticos
title_short The use of clozapine and other antipsychotics for treatment-resistant schizophrenia at the brazilian psychosocial care centers in Joao Pessoa, PB, Brazil
title_full The use of clozapine and other antipsychotics for treatment-resistant schizophrenia at the brazilian psychosocial care centers in Joao Pessoa, PB, Brazil
title_fullStr The use of clozapine and other antipsychotics for treatment-resistant schizophrenia at the brazilian psychosocial care centers in Joao Pessoa, PB, Brazil
title_full_unstemmed The use of clozapine and other antipsychotics for treatment-resistant schizophrenia at the brazilian psychosocial care centers in Joao Pessoa, PB, Brazil
title_sort The use of clozapine and other antipsychotics for treatment-resistant schizophrenia at the brazilian psychosocial care centers in Joao Pessoa, PB, Brazil
author Nascimento, Gabriela Jorge do
author_facet Nascimento, Gabriela Jorge do
Medeiros, Heydrich Lopes Virgulino de
author_role author
author2 Medeiros, Heydrich Lopes Virgulino de
author2_role author
dc.contributor.author.fl_str_mv Nascimento, Gabriela Jorge do
Medeiros, Heydrich Lopes Virgulino de
dc.subject.por.fl_str_mv esquizofrenia resistente
clozapina
antipsicóticos
resistant schizophrenia
clozapine
antipsychotics
esquizofrenia resistente
clozapina
antipsicóticos
topic esquizofrenia resistente
clozapina
antipsicóticos
resistant schizophrenia
clozapine
antipsychotics
esquizofrenia resistente
clozapina
antipsicóticos
description Introduction: Although Clozapine is the drug recommended for treatment-resistant schizophrenia (TRS), it is underprescribed. Objectives: To analyze the pattern of clozapine prescription and use of other antipsychotics for patients with treatment-resistant schizophrenia in community mental health centers in Joao Pessoa. Methods: Antipsychotic prescriptions and medical records of patients with schizophrenia were reviewed. The psychiatrists of the services completed a survey on the difficulties associated with prescribing clozapine. Results: Among 381 patients with schizophrenia, 102 (26.8%) met the TRS criteria. Forty of the TRS patients (39.2%) were in polypharmacy; 25 in atypical antipsychotic monotherapy (24.6%), 3 with typical antipsychotic monotherapy (3%), and only 34 were using clozapine (33.3%). An important obstacle is the logistics required for blood counts routine. Conclusion: The most TRS patients (66.7%) was prescribed non-clozapine treatment, mostly polypharmacy, at the Brazilian Psychosocial Care Centers in Joao Pessoa.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-11
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-Reviewed
Revisado por Pares
Avaliado Pelos Pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistardp.org.br/revista/article/view/511
10.25118/2763-9037.2023.v13.511
url https://revistardp.org.br/revista/article/view/511
identifier_str_mv 10.25118/2763-9037.2023.v13.511
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistardp.org.br/revista/article/view/511/731
dc.rights.driver.fl_str_mv Copyright (c) 2023 Gabriela Jorge do Nascimento, Heydrich Lopes Virgulino de Medeiros
https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Gabriela Jorge do Nascimento, Heydrich Lopes Virgulino de Medeiros
https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
dc.source.none.fl_str_mv Debates in Psychiatry; Vol. 13 (2023); 1-18
Debates em Psiquiatria; Vol. 13 (2023); 1-18
Debates em Psiquiatria; v. 13 (2023); 1-18
2763-9037
2236-918X
reponame:Debates em Psiquiatria (Online)
instname:Associação Brasileira de Psiquiatria (ABP)
instacron:ABP
instname_str Associação Brasileira de Psiquiatria (ABP)
instacron_str ABP
institution ABP
reponame_str Debates em Psiquiatria (Online)
collection Debates em Psiquiatria (Online)
repository.name.fl_str_mv Debates em Psiquiatria (Online) - Associação Brasileira de Psiquiatria (ABP)
repository.mail.fl_str_mv rdp@abp.org.br
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