Alcohol-induced epigenetic mechanisms in the expression of genes influencing suicidal behavior: fact or coincidence?

Detalhes bibliográficos
Autor(a) principal: Brunelli, Lisandre F.
Data de Publicação: 2015
Tipo de documento: Artigo
Idioma: por
Título da fonte: Debates em Psiquiatria (Online)
Texto Completo: https://revistardp.org.br/revista/article/view/165
Resumo: The objective of this article was to shed light on a very common topic in our society as well as in our globalized world, namely, the relationship between suicide and alcohol. The high number of suicides currently observedcan be considered a public health problem. At the same time, alcohol abuse has been shown to precede several organic and mental disorders, acting as a facilitator of bizarre behaviors, erroneous judgments, and impulsive acts. Epigenetics explains the possible relationship between the two events (suicidal behavior and alcohol abuse) through the activation of specific genes that would be involved in the process. Current research can help improve the treatment of severe psychiatric disorders through the study and use of psychotropic drugs that will act on specific pharmacological targets or even prevent risky behaviors that may have fatal consequences.
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spelling Alcohol-induced epigenetic mechanisms in the expression of genes influencing suicidal behavior: fact or coincidence?Mecanismos epigenéticos induzidos pelo álcool na expressão de genes determinantes do comportamento suicida: fato ou acaso?Suicídiorepressão epigenéticaalcoolismometilaçãoSuicideepigenetic repressionalcoholismmethylationThe objective of this article was to shed light on a very common topic in our society as well as in our globalized world, namely, the relationship between suicide and alcohol. The high number of suicides currently observedcan be considered a public health problem. At the same time, alcohol abuse has been shown to precede several organic and mental disorders, acting as a facilitator of bizarre behaviors, erroneous judgments, and impulsive acts. Epigenetics explains the possible relationship between the two events (suicidal behavior and alcohol abuse) through the activation of specific genes that would be involved in the process. Current research can help improve the treatment of severe psychiatric disorders through the study and use of psychotropic drugs that will act on specific pharmacological targets or even prevent risky behaviors that may have fatal consequences.O presente artigo tem como intuito lançar luz sobre um tema bastante comum em nossa sociedade, assim como em nosso mundo globalizado, a saber, a relação entre alcoolismo e suicídio. O grande número de suicídios que vêm ocorrendo atualmente pode ser considerado um problema de saúde pública. Concomitantemente, o alcoolismo tem sido evidenciado como agente precursor de diversos transtornos orgânicos e mentais, agindo como meio facilitador para comportamentos bizarros, julgamentos equivocados e atos impulsivos. A epigenética explica a possível relação entre tais eventos (comportamento suicida e alcoolismo) através da ativação de genes específicos que estariam envolvidos no processo. Pesquisas atuais podem auxiliar no tratamento de transtornos psiquiátricos graves através do estudo e emprego de psicofármacos que vão agir de forma direcionada a alvos farmacológicos específicos e até prevenir comportamentos de risco que possam culminar de forma fatal.Associação Brasileira de Psiquiatria2015-08-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-ReviewedRevisado por ParesAvaliado Pelos Paresapplication/pdfhttps://revistardp.org.br/revista/article/view/16510.25118/2236-918X-5-4-5Debates in Psychiatry; Vol. 5 No. 4 (2015); 34-36Debates em Psiquiatria; Vol. 5 Núm. 4 (2015); 34-36Debates em Psiquiatria; v. 5 n. 4 (2015); 34-362763-90372236-918Xreponame:Debates em Psiquiatria (Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABPporhttps://revistardp.org.br/revista/article/view/165/147https://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessBrunelli, Lisandre F.2022-07-14T01:26:44Zoai:ojs.emnuvens.com.br:article/165Revistahttps://revistardp.org.br/revista/oaiPUBhttps://revistardp.org.br/revista/oairdp@abp.org.br2763-90372236-918Xopendoar:2022-07-14T01:26:44Debates em Psiquiatria (Online) - Associação Brasileira de Psiquiatria (ABP)false
dc.title.none.fl_str_mv Alcohol-induced epigenetic mechanisms in the expression of genes influencing suicidal behavior: fact or coincidence?
Mecanismos epigenéticos induzidos pelo álcool na expressão de genes determinantes do comportamento suicida: fato ou acaso?
title Alcohol-induced epigenetic mechanisms in the expression of genes influencing suicidal behavior: fact or coincidence?
spellingShingle Alcohol-induced epigenetic mechanisms in the expression of genes influencing suicidal behavior: fact or coincidence?
Brunelli, Lisandre F.
Suicídio
repressão epigenética
alcoolismo
metilação
Suicide
epigenetic repression
alcoholism
methylation
title_short Alcohol-induced epigenetic mechanisms in the expression of genes influencing suicidal behavior: fact or coincidence?
title_full Alcohol-induced epigenetic mechanisms in the expression of genes influencing suicidal behavior: fact or coincidence?
title_fullStr Alcohol-induced epigenetic mechanisms in the expression of genes influencing suicidal behavior: fact or coincidence?
title_full_unstemmed Alcohol-induced epigenetic mechanisms in the expression of genes influencing suicidal behavior: fact or coincidence?
title_sort Alcohol-induced epigenetic mechanisms in the expression of genes influencing suicidal behavior: fact or coincidence?
author Brunelli, Lisandre F.
author_facet Brunelli, Lisandre F.
author_role author
dc.contributor.author.fl_str_mv Brunelli, Lisandre F.
dc.subject.por.fl_str_mv Suicídio
repressão epigenética
alcoolismo
metilação
Suicide
epigenetic repression
alcoholism
methylation
topic Suicídio
repressão epigenética
alcoolismo
metilação
Suicide
epigenetic repression
alcoholism
methylation
description The objective of this article was to shed light on a very common topic in our society as well as in our globalized world, namely, the relationship between suicide and alcohol. The high number of suicides currently observedcan be considered a public health problem. At the same time, alcohol abuse has been shown to precede several organic and mental disorders, acting as a facilitator of bizarre behaviors, erroneous judgments, and impulsive acts. Epigenetics explains the possible relationship between the two events (suicidal behavior and alcohol abuse) through the activation of specific genes that would be involved in the process. Current research can help improve the treatment of severe psychiatric disorders through the study and use of psychotropic drugs that will act on specific pharmacological targets or even prevent risky behaviors that may have fatal consequences.
publishDate 2015
dc.date.none.fl_str_mv 2015-08-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-Reviewed
Revisado por Pares
Avaliado Pelos Pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistardp.org.br/revista/article/view/165
10.25118/2236-918X-5-4-5
url https://revistardp.org.br/revista/article/view/165
identifier_str_mv 10.25118/2236-918X-5-4-5
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistardp.org.br/revista/article/view/165/147
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
dc.source.none.fl_str_mv Debates in Psychiatry; Vol. 5 No. 4 (2015); 34-36
Debates em Psiquiatria; Vol. 5 Núm. 4 (2015); 34-36
Debates em Psiquiatria; v. 5 n. 4 (2015); 34-36
2763-9037
2236-918X
reponame:Debates em Psiquiatria (Online)
instname:Associação Brasileira de Psiquiatria (ABP)
instacron:ABP
instname_str Associação Brasileira de Psiquiatria (ABP)
instacron_str ABP
institution ABP
reponame_str Debates em Psiquiatria (Online)
collection Debates em Psiquiatria (Online)
repository.name.fl_str_mv Debates em Psiquiatria (Online) - Associação Brasileira de Psiquiatria (ABP)
repository.mail.fl_str_mv rdp@abp.org.br
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