Leptin Levels, Basal Metabolic Rates, and Insulin Resistance in Obese Pubertal Children

Detalhes bibliográficos
Autor(a) principal: Conterato, Elisabete Vieira
Data de Publicação: 2022
Outros Autores: Machado, Tania Diniz, Nogueira-de-Almeida, Carlos Alberto, Mello, Elza Daniel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: International Journal of Nutrology (Online)
Texto Completo: https://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/193
Resumo: Introduction: Obesity in children and adolescents is considered a serious public health problem. The consequences of overweight can last for life. It is extremely important to have formulas to calculate the basal metabolic rate (BMR) that are truly reliable in relation to the individual caloric expenditure. Objectives: To investigate the association of serum levels of leptin, lipid profile, and insulin resistance (insuline resistance by Homeostatic Model Assessment [HOMA] index) with the body mass index (BMI) z-score of pubertal obese children. In addition, to compare the basal metabolic rate (BMR) evaluation carried out using bioimpedance (BIA) with the Food and Agricultural Organization/World Health Organization (FAO/WHO) equation. Methods: Cross-sectional study including 37 pubertal obese children (aged 7 to 12 years old) seen for the first time in the outpatient care unit specialized in child obesity between June 2013 and April 2014. The participants were assessed regarding anthropometric data, body composition (fat mass) by BIA 310 bioimpedance analyzer (Biodynamic Body Composition Analyser, model 310 - Biodynamics Corporation, Seattle, EUA), and blood pressure. Blood samples were collected to measure glucose, insulin, lipid profile, triglycerides, and leptin. The stage of sexual maturity was determined by self-assessment according to the Tanner scale. Results: Higher leptin levels were found in the severe obesity group (p = 0.007) and, as expected, higher BMI (p < 0.001), and fat mass (p = 0.029). The groups did not differ in relation to insulin, insulin resistance (HOMA-IR), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and blood pressure. The BMR measured by bioimpedance was lower as compared to the measure by the FAO/WHO equation (p < 0.001). Conclusions: These results suggest that severely obese children may present leptin resistance in this early stage of life, (since this hormone is higher in these children). It is suggested that health professionals prioritize the calculation of BMR by bioimpedance, since the FAO/WHO equation seems to overestimate the caloric values.
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spelling Leptin Levels, Basal Metabolic Rates, and Insulin Resistance in Obese Pubertal Childrenbasal metabolismchildinsulin resistanceleptinobesityIntroduction: Obesity in children and adolescents is considered a serious public health problem. The consequences of overweight can last for life. It is extremely important to have formulas to calculate the basal metabolic rate (BMR) that are truly reliable in relation to the individual caloric expenditure. Objectives: To investigate the association of serum levels of leptin, lipid profile, and insulin resistance (insuline resistance by Homeostatic Model Assessment [HOMA] index) with the body mass index (BMI) z-score of pubertal obese children. In addition, to compare the basal metabolic rate (BMR) evaluation carried out using bioimpedance (BIA) with the Food and Agricultural Organization/World Health Organization (FAO/WHO) equation. Methods: Cross-sectional study including 37 pubertal obese children (aged 7 to 12 years old) seen for the first time in the outpatient care unit specialized in child obesity between June 2013 and April 2014. The participants were assessed regarding anthropometric data, body composition (fat mass) by BIA 310 bioimpedance analyzer (Biodynamic Body Composition Analyser, model 310 - Biodynamics Corporation, Seattle, EUA), and blood pressure. Blood samples were collected to measure glucose, insulin, lipid profile, triglycerides, and leptin. The stage of sexual maturity was determined by self-assessment according to the Tanner scale. Results: Higher leptin levels were found in the severe obesity group (p = 0.007) and, as expected, higher BMI (p < 0.001), and fat mass (p = 0.029). The groups did not differ in relation to insulin, insulin resistance (HOMA-IR), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and blood pressure. The BMR measured by bioimpedance was lower as compared to the measure by the FAO/WHO equation (p < 0.001). Conclusions: These results suggest that severely obese children may present leptin resistance in this early stage of life, (since this hormone is higher in these children). It is suggested that health professionals prioritize the calculation of BMR by bioimpedance, since the FAO/WHO equation seems to overestimate the caloric values.MetaScience Press2022-03-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed Articleapplication/pdfhttps://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/19310.1055/s-0040-1713796International Journal of Nutrology; Vol. 13 No. 1 (2020): International Journal of Nutrology (IJN) - July 2020; 17-232595-28541984-301110.1055/s-010-49036reponame:International Journal of Nutrology (Online)instname:Associação Brasileira de Nutrologia (ABRAN)instacron:ABRANenghttps://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/193/189Copyright (c) 2022 International Journal of Nutrologyinfo:eu-repo/semantics/openAccessConterato, Elisabete VieiraMachado, Tania DinizNogueira-de-Almeida, Carlos AlbertoMello, Elza Daniel2022-03-06T22:41:35Zoai:ojs2.ijn.zotarellifilhoscientificworks.com:article/193Revistahttps://ijn.zotarellifilhoscientificworks.com/index.php/ijnONGhttps://ijn.zotarellifilhoscientificworks.com/index.php/ijn/oaiijn@zotarellifilhoscientificworks.com || editorchief@zotarellifilhoscientificworks.com10.544482595-28541984-3011opendoar:2022-03-06T22:41:35International Journal of Nutrology (Online) - Associação Brasileira de Nutrologia (ABRAN)false
dc.title.none.fl_str_mv Leptin Levels, Basal Metabolic Rates, and Insulin Resistance in Obese Pubertal Children
title Leptin Levels, Basal Metabolic Rates, and Insulin Resistance in Obese Pubertal Children
spellingShingle Leptin Levels, Basal Metabolic Rates, and Insulin Resistance in Obese Pubertal Children
Conterato, Elisabete Vieira
basal metabolism
child
insulin resistance
leptin
obesity
title_short Leptin Levels, Basal Metabolic Rates, and Insulin Resistance in Obese Pubertal Children
title_full Leptin Levels, Basal Metabolic Rates, and Insulin Resistance in Obese Pubertal Children
title_fullStr Leptin Levels, Basal Metabolic Rates, and Insulin Resistance in Obese Pubertal Children
title_full_unstemmed Leptin Levels, Basal Metabolic Rates, and Insulin Resistance in Obese Pubertal Children
title_sort Leptin Levels, Basal Metabolic Rates, and Insulin Resistance in Obese Pubertal Children
author Conterato, Elisabete Vieira
author_facet Conterato, Elisabete Vieira
Machado, Tania Diniz
Nogueira-de-Almeida, Carlos Alberto
Mello, Elza Daniel
author_role author
author2 Machado, Tania Diniz
Nogueira-de-Almeida, Carlos Alberto
Mello, Elza Daniel
author2_role author
author
author
dc.contributor.author.fl_str_mv Conterato, Elisabete Vieira
Machado, Tania Diniz
Nogueira-de-Almeida, Carlos Alberto
Mello, Elza Daniel
dc.subject.por.fl_str_mv basal metabolism
child
insulin resistance
leptin
obesity
topic basal metabolism
child
insulin resistance
leptin
obesity
description Introduction: Obesity in children and adolescents is considered a serious public health problem. The consequences of overweight can last for life. It is extremely important to have formulas to calculate the basal metabolic rate (BMR) that are truly reliable in relation to the individual caloric expenditure. Objectives: To investigate the association of serum levels of leptin, lipid profile, and insulin resistance (insuline resistance by Homeostatic Model Assessment [HOMA] index) with the body mass index (BMI) z-score of pubertal obese children. In addition, to compare the basal metabolic rate (BMR) evaluation carried out using bioimpedance (BIA) with the Food and Agricultural Organization/World Health Organization (FAO/WHO) equation. Methods: Cross-sectional study including 37 pubertal obese children (aged 7 to 12 years old) seen for the first time in the outpatient care unit specialized in child obesity between June 2013 and April 2014. The participants were assessed regarding anthropometric data, body composition (fat mass) by BIA 310 bioimpedance analyzer (Biodynamic Body Composition Analyser, model 310 - Biodynamics Corporation, Seattle, EUA), and blood pressure. Blood samples were collected to measure glucose, insulin, lipid profile, triglycerides, and leptin. The stage of sexual maturity was determined by self-assessment according to the Tanner scale. Results: Higher leptin levels were found in the severe obesity group (p = 0.007) and, as expected, higher BMI (p < 0.001), and fat mass (p = 0.029). The groups did not differ in relation to insulin, insulin resistance (HOMA-IR), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and blood pressure. The BMR measured by bioimpedance was lower as compared to the measure by the FAO/WHO equation (p < 0.001). Conclusions: These results suggest that severely obese children may present leptin resistance in this early stage of life, (since this hormone is higher in these children). It is suggested that health professionals prioritize the calculation of BMR by bioimpedance, since the FAO/WHO equation seems to overestimate the caloric values.
publishDate 2022
dc.date.none.fl_str_mv 2022-03-06
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/193
10.1055/s-0040-1713796
url https://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/193
identifier_str_mv 10.1055/s-0040-1713796
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/193/189
dc.rights.driver.fl_str_mv Copyright (c) 2022 International Journal of Nutrology
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 International Journal of Nutrology
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MetaScience Press
publisher.none.fl_str_mv MetaScience Press
dc.source.none.fl_str_mv International Journal of Nutrology; Vol. 13 No. 1 (2020): International Journal of Nutrology (IJN) - July 2020; 17-23
2595-2854
1984-3011
10.1055/s-010-49036
reponame:International Journal of Nutrology (Online)
instname:Associação Brasileira de Nutrologia (ABRAN)
instacron:ABRAN
instname_str Associação Brasileira de Nutrologia (ABRAN)
instacron_str ABRAN
institution ABRAN
reponame_str International Journal of Nutrology (Online)
collection International Journal of Nutrology (Online)
repository.name.fl_str_mv International Journal of Nutrology (Online) - Associação Brasileira de Nutrologia (ABRAN)
repository.mail.fl_str_mv ijn@zotarellifilhoscientificworks.com || editorchief@zotarellifilhoscientificworks.com
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