Investigation of regenerative nutrology of cells/molecules to the organism: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | International Journal of Nutrology (Online) |
Texto Completo: | https://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/349 |
Resumo: | Introduction: In the context of tissue regeneration and nutrology, stem cells from adult tissue mediate homeostasis and regeneration of tissues and organs. These decisions are directly integrated with the body's energy balance and nutritional status. Endogenous metabolites and dietary nutrients can directly influence epigenetic enzymes. Objective: It was to carry out a systematic review of the regenerative nutrology of cells and molecules in the body. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from April to June 2023 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 112 articles were found. A total of 45 articles were evaluated in full and 25 were included and developed in this systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 18 studies with a high risk of bias and 18 studies that did not meet GRADE. It was evidenced that the metabolism of stem cells was centered on the central metabolism of carbon and the balance between glycolysis versus oxidative phosphorylation in the regulation of cell destiny. Epigenetic modifications to DNA and histones, proteins that alter cellular fate, control chromatin accessibility and downstream gene expression. In addition to the connection between metabolism and epigenetic pathways, nutrients can impact cellular status by modulating signaling pathway activity. A clear example is through the mechanistic targeting of the rapamycin (mTOR) signaling pathway, and in particular the mTOR 1 complex. Nutritional supplementation accelerated the healing of skin ulcers and reduced the intensity of wound care in non-malnourished patients. |
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International Journal of Nutrology (Online) |
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Investigation of regenerative nutrology of cells/molecules to the organism: a systematic reviewNutrologyTissue regenerationMetabolismEpigeneticsNutrientsIntroduction: In the context of tissue regeneration and nutrology, stem cells from adult tissue mediate homeostasis and regeneration of tissues and organs. These decisions are directly integrated with the body's energy balance and nutritional status. Endogenous metabolites and dietary nutrients can directly influence epigenetic enzymes. Objective: It was to carry out a systematic review of the regenerative nutrology of cells and molecules in the body. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from April to June 2023 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 112 articles were found. A total of 45 articles were evaluated in full and 25 were included and developed in this systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 18 studies with a high risk of bias and 18 studies that did not meet GRADE. It was evidenced that the metabolism of stem cells was centered on the central metabolism of carbon and the balance between glycolysis versus oxidative phosphorylation in the regulation of cell destiny. Epigenetic modifications to DNA and histones, proteins that alter cellular fate, control chromatin accessibility and downstream gene expression. In addition to the connection between metabolism and epigenetic pathways, nutrients can impact cellular status by modulating signaling pathway activity. A clear example is through the mechanistic targeting of the rapamycin (mTOR) signaling pathway, and in particular the mTOR 1 complex. Nutritional supplementation accelerated the healing of skin ulcers and reduced the intensity of wound care in non-malnourished patients.MetaScience Press2024-03-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/34910.54448/ijn24201International Journal of Nutrology; Vol. 17 No. 2 (2024): International Journal of Nutrology (IJN) - May 20242595-28541984-3011reponame:International Journal of Nutrology (Online)instname:Associação Brasileira de Nutrologia (ABRAN)instacron:ABRANenghttps://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/349/324Copyright (c) 2024 Alessandra Leal de Oliveira, Thuany da Silva Teixeira, Mariana Carolina Braga, Lucas Emanuel de Lima Azevedo, Lara Souza Crepaldi, Renata Cristina Taveira Azevedo, Nathalia Galindo Cordeiro, Rodrigo siqueira de Carvalho, Cristiana Alvarenga Spadinger Soareshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessOliveira, Alessandra Leal deTeixeira, Thuany da SilvaBraga, Mariana CarolinaAzevedo, Lucas Emanuel de LimaCrepaldi, Lara Souza Azevedo, Renata Cristina TaveiraCordeiro, Nathalia GalindoCarvalho, Rodrigo siqueira deSoares, Cristiana Alvarenga Spadinger2024-03-19T13:59:40Zoai:ojs2.ijn.zotarellifilhoscientificworks.com:article/349Revistahttps://ijn.zotarellifilhoscientificworks.com/index.php/ijnONGhttps://ijn.zotarellifilhoscientificworks.com/index.php/ijn/oaiijn@zotarellifilhoscientificworks.com || editorchief@zotarellifilhoscientificworks.com10.544482595-28541984-3011opendoar:2024-03-19T13:59:40International Journal of Nutrology (Online) - Associação Brasileira de Nutrologia (ABRAN)false |
dc.title.none.fl_str_mv |
Investigation of regenerative nutrology of cells/molecules to the organism: a systematic review |
title |
Investigation of regenerative nutrology of cells/molecules to the organism: a systematic review |
spellingShingle |
Investigation of regenerative nutrology of cells/molecules to the organism: a systematic review Oliveira, Alessandra Leal de Nutrology Tissue regeneration Metabolism Epigenetics Nutrients |
title_short |
Investigation of regenerative nutrology of cells/molecules to the organism: a systematic review |
title_full |
Investigation of regenerative nutrology of cells/molecules to the organism: a systematic review |
title_fullStr |
Investigation of regenerative nutrology of cells/molecules to the organism: a systematic review |
title_full_unstemmed |
Investigation of regenerative nutrology of cells/molecules to the organism: a systematic review |
title_sort |
Investigation of regenerative nutrology of cells/molecules to the organism: a systematic review |
author |
Oliveira, Alessandra Leal de |
author_facet |
Oliveira, Alessandra Leal de Teixeira, Thuany da Silva Braga, Mariana Carolina Azevedo, Lucas Emanuel de Lima Crepaldi, Lara Souza Azevedo, Renata Cristina Taveira Cordeiro, Nathalia Galindo Carvalho, Rodrigo siqueira de Soares, Cristiana Alvarenga Spadinger |
author_role |
author |
author2 |
Teixeira, Thuany da Silva Braga, Mariana Carolina Azevedo, Lucas Emanuel de Lima Crepaldi, Lara Souza Azevedo, Renata Cristina Taveira Cordeiro, Nathalia Galindo Carvalho, Rodrigo siqueira de Soares, Cristiana Alvarenga Spadinger |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Alessandra Leal de Teixeira, Thuany da Silva Braga, Mariana Carolina Azevedo, Lucas Emanuel de Lima Crepaldi, Lara Souza Azevedo, Renata Cristina Taveira Cordeiro, Nathalia Galindo Carvalho, Rodrigo siqueira de Soares, Cristiana Alvarenga Spadinger |
dc.subject.por.fl_str_mv |
Nutrology Tissue regeneration Metabolism Epigenetics Nutrients |
topic |
Nutrology Tissue regeneration Metabolism Epigenetics Nutrients |
description |
Introduction: In the context of tissue regeneration and nutrology, stem cells from adult tissue mediate homeostasis and regeneration of tissues and organs. These decisions are directly integrated with the body's energy balance and nutritional status. Endogenous metabolites and dietary nutrients can directly influence epigenetic enzymes. Objective: It was to carry out a systematic review of the regenerative nutrology of cells and molecules in the body. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from April to June 2023 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 112 articles were found. A total of 45 articles were evaluated in full and 25 were included and developed in this systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 18 studies with a high risk of bias and 18 studies that did not meet GRADE. It was evidenced that the metabolism of stem cells was centered on the central metabolism of carbon and the balance between glycolysis versus oxidative phosphorylation in the regulation of cell destiny. Epigenetic modifications to DNA and histones, proteins that alter cellular fate, control chromatin accessibility and downstream gene expression. In addition to the connection between metabolism and epigenetic pathways, nutrients can impact cellular status by modulating signaling pathway activity. A clear example is through the mechanistic targeting of the rapamycin (mTOR) signaling pathway, and in particular the mTOR 1 complex. Nutritional supplementation accelerated the healing of skin ulcers and reduced the intensity of wound care in non-malnourished patients. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-03-18 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/349 10.54448/ijn24201 |
url |
https://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/349 |
identifier_str_mv |
10.54448/ijn24201 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/349/324 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MetaScience Press |
publisher.none.fl_str_mv |
MetaScience Press |
dc.source.none.fl_str_mv |
International Journal of Nutrology; Vol. 17 No. 2 (2024): International Journal of Nutrology (IJN) - May 2024 2595-2854 1984-3011 reponame:International Journal of Nutrology (Online) instname:Associação Brasileira de Nutrologia (ABRAN) instacron:ABRAN |
instname_str |
Associação Brasileira de Nutrologia (ABRAN) |
instacron_str |
ABRAN |
institution |
ABRAN |
reponame_str |
International Journal of Nutrology (Online) |
collection |
International Journal of Nutrology (Online) |
repository.name.fl_str_mv |
International Journal of Nutrology (Online) - Associação Brasileira de Nutrologia (ABRAN) |
repository.mail.fl_str_mv |
ijn@zotarellifilhoscientificworks.com || editorchief@zotarellifilhoscientificworks.com |
_version_ |
1797041990904315904 |