False hyperparathyroids secondary to biotin prolonged use: a case report
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | International Journal of Nutrology (Online) |
Texto Completo: | https://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/229 |
Resumo: | A 55-year-old overweight female patient with elevated parathyroid hormone (PTH) levels, without any other major plasma biochemical abnormalities, and with normal vitamin D and calcium levels. The condition was suggestive of normocalcemic primary hyperparathyroidism. Bone densitometry and 24-hour calciuria were normal. After extensive investigation and possible referral for exploratory surgery, the patient reported continued and chronic use of biotin supplementation (2.5 mg per day). Repeated tests after discontinuing the use of vitamin B7 showed normal PTH levels without surgical or pharmacological interventions. Biotin supplementation associated with the use of this vitamin as a component of biological assays for hormone dosage can generate incorrect laboratory results, which puts medical conduct at risk with inaccurate diagnoses and unnecessary procedures. Although, different substances or emotional conditions can interfere with hormone dosages, one must consider the use of food supplements such as biotin since it can also generate unreliable results. Discontinuation of the use of biotin, in addition to the assessment of serum biotin levels prior to hormone dosing is necessary for a correct evaluation of serum PTH levels. This study was analyzed and approved by the Research Ethics Committee, and obtaining the Informed Consent Form according to CNS/CONEP Resolution 466/12. |
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False hyperparathyroids secondary to biotin prolonged use: a case reportPrimary hyperparathyroidismParathyroid hormoneBiotinA 55-year-old overweight female patient with elevated parathyroid hormone (PTH) levels, without any other major plasma biochemical abnormalities, and with normal vitamin D and calcium levels. The condition was suggestive of normocalcemic primary hyperparathyroidism. Bone densitometry and 24-hour calciuria were normal. After extensive investigation and possible referral for exploratory surgery, the patient reported continued and chronic use of biotin supplementation (2.5 mg per day). Repeated tests after discontinuing the use of vitamin B7 showed normal PTH levels without surgical or pharmacological interventions. Biotin supplementation associated with the use of this vitamin as a component of biological assays for hormone dosage can generate incorrect laboratory results, which puts medical conduct at risk with inaccurate diagnoses and unnecessary procedures. Although, different substances or emotional conditions can interfere with hormone dosages, one must consider the use of food supplements such as biotin since it can also generate unreliable results. Discontinuation of the use of biotin, in addition to the assessment of serum biotin levels prior to hormone dosing is necessary for a correct evaluation of serum PTH levels. This study was analyzed and approved by the Research Ethics Committee, and obtaining the Informed Consent Form according to CNS/CONEP Resolution 466/12.MetaScience Press2022-05-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/22910.54448/ijn22207International Journal of Nutrology; Vol. 15 No. 2 (2022): International Journal of Nutrology (IJN) - May 20222595-28541984-301110.54448/ijn222reponame:International Journal of Nutrology (Online)instname:Associação Brasileira de Nutrologia (ABRAN)instacron:ABRANenghttps://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/229/224Copyright (c) 2022 International Journal of Nutrologyinfo:eu-repo/semantics/openAccessNeves, GeorgeanneLira, Eduardo Carvalho2022-05-25T19:10:40Zoai:ojs2.ijn.zotarellifilhoscientificworks.com:article/229Revistahttps://ijn.zotarellifilhoscientificworks.com/index.php/ijnONGhttps://ijn.zotarellifilhoscientificworks.com/index.php/ijn/oaiijn@zotarellifilhoscientificworks.com || editorchief@zotarellifilhoscientificworks.com10.544482595-28541984-3011opendoar:2022-05-25T19:10:40International Journal of Nutrology (Online) - Associação Brasileira de Nutrologia (ABRAN)false |
dc.title.none.fl_str_mv |
False hyperparathyroids secondary to biotin prolonged use: a case report |
title |
False hyperparathyroids secondary to biotin prolonged use: a case report |
spellingShingle |
False hyperparathyroids secondary to biotin prolonged use: a case report Neves, Georgeanne Primary hyperparathyroidism Parathyroid hormone Biotin |
title_short |
False hyperparathyroids secondary to biotin prolonged use: a case report |
title_full |
False hyperparathyroids secondary to biotin prolonged use: a case report |
title_fullStr |
False hyperparathyroids secondary to biotin prolonged use: a case report |
title_full_unstemmed |
False hyperparathyroids secondary to biotin prolonged use: a case report |
title_sort |
False hyperparathyroids secondary to biotin prolonged use: a case report |
author |
Neves, Georgeanne |
author_facet |
Neves, Georgeanne Lira, Eduardo Carvalho |
author_role |
author |
author2 |
Lira, Eduardo Carvalho |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Neves, Georgeanne Lira, Eduardo Carvalho |
dc.subject.por.fl_str_mv |
Primary hyperparathyroidism Parathyroid hormone Biotin |
topic |
Primary hyperparathyroidism Parathyroid hormone Biotin |
description |
A 55-year-old overweight female patient with elevated parathyroid hormone (PTH) levels, without any other major plasma biochemical abnormalities, and with normal vitamin D and calcium levels. The condition was suggestive of normocalcemic primary hyperparathyroidism. Bone densitometry and 24-hour calciuria were normal. After extensive investigation and possible referral for exploratory surgery, the patient reported continued and chronic use of biotin supplementation (2.5 mg per day). Repeated tests after discontinuing the use of vitamin B7 showed normal PTH levels without surgical or pharmacological interventions. Biotin supplementation associated with the use of this vitamin as a component of biological assays for hormone dosage can generate incorrect laboratory results, which puts medical conduct at risk with inaccurate diagnoses and unnecessary procedures. Although, different substances or emotional conditions can interfere with hormone dosages, one must consider the use of food supplements such as biotin since it can also generate unreliable results. Discontinuation of the use of biotin, in addition to the assessment of serum biotin levels prior to hormone dosing is necessary for a correct evaluation of serum PTH levels. This study was analyzed and approved by the Research Ethics Committee, and obtaining the Informed Consent Form according to CNS/CONEP Resolution 466/12. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-25 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/229 10.54448/ijn22207 |
url |
https://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/229 |
identifier_str_mv |
10.54448/ijn22207 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/229/224 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 International Journal of Nutrology info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 International Journal of Nutrology |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MetaScience Press |
publisher.none.fl_str_mv |
MetaScience Press |
dc.source.none.fl_str_mv |
International Journal of Nutrology; Vol. 15 No. 2 (2022): International Journal of Nutrology (IJN) - May 2022 2595-2854 1984-3011 10.54448/ijn222 reponame:International Journal of Nutrology (Online) instname:Associação Brasileira de Nutrologia (ABRAN) instacron:ABRAN |
instname_str |
Associação Brasileira de Nutrologia (ABRAN) |
instacron_str |
ABRAN |
institution |
ABRAN |
reponame_str |
International Journal of Nutrology (Online) |
collection |
International Journal of Nutrology (Online) |
repository.name.fl_str_mv |
International Journal of Nutrology (Online) - Associação Brasileira de Nutrologia (ABRAN) |
repository.mail.fl_str_mv |
ijn@zotarellifilhoscientificworks.com || editorchief@zotarellifilhoscientificworks.com |
_version_ |
1792204588341788672 |