Iron peptide complex does not increase blood iron concentration at the same extent as ferrous sulfate after oral ingestion in healthy adult males
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | International Journal of Nutrology (Online) |
Texto Completo: | https://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/35 |
Resumo: | Iron-deficient anemia continues to be one of the major nutritional and public health problems all over the world. Although ferrous sulfate is largely used for the prevention and treatment of this deficiency, the gastrointestinal side effects preclude its use in some cases. This study aimed to compare the effect of iron peptide complex and ferrous sulfate on serum iron and to examine serial serum iron levels. Ten volunteers were submitted to 5 different treatments: Control (C), Ferrous sulfate 60 mg (FS), Iron peptide 60 mg (IP1), Iron peptide 80 mg (IP2) and Iron peptide 60 mg plus diet (IPD). In the first treatment (C), empty capsules were given, whereas in the second (FS), third (IP1), fourth (IP2) and fifth (IPD) treatments, ferrous sulfate 60 mg, iron peptide complex 60 mg, iron peptide complex 80 mg and iron peptide complex 60 mg plus diet were given in a randomized crossover design, with a washout period of 1 week. The products were offered as capsules and blood samples were drawn at the following time points: 0, 30, 60, 120, 240, 480 and 720 minutes after oral intake. FS produced higher serum iron levels than Control, IP1, IP2 and IPD (P< 0.05). The areas under the curves for serum iron for the different compounds gave AUCFS > AUCC = AUCIP1 = AUCIP2 = AUCIPD. Conclusions: The iron peptide complex did not increase blood iron FS C IP1 IP2 IPD concentration as compared to control and ferrous sulfate at the respective time points. |
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International Journal of Nutrology (Online) |
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Iron peptide complex does not increase blood iron concentration at the same extent as ferrous sulfate after oral ingestion in healthy adult malesFerrous sulfateiron-peptide complexserum ironanemiairon deficiencyIron-deficient anemia continues to be one of the major nutritional and public health problems all over the world. Although ferrous sulfate is largely used for the prevention and treatment of this deficiency, the gastrointestinal side effects preclude its use in some cases. This study aimed to compare the effect of iron peptide complex and ferrous sulfate on serum iron and to examine serial serum iron levels. Ten volunteers were submitted to 5 different treatments: Control (C), Ferrous sulfate 60 mg (FS), Iron peptide 60 mg (IP1), Iron peptide 80 mg (IP2) and Iron peptide 60 mg plus diet (IPD). In the first treatment (C), empty capsules were given, whereas in the second (FS), third (IP1), fourth (IP2) and fifth (IPD) treatments, ferrous sulfate 60 mg, iron peptide complex 60 mg, iron peptide complex 80 mg and iron peptide complex 60 mg plus diet were given in a randomized crossover design, with a washout period of 1 week. The products were offered as capsules and blood samples were drawn at the following time points: 0, 30, 60, 120, 240, 480 and 720 minutes after oral intake. FS produced higher serum iron levels than Control, IP1, IP2 and IPD (P< 0.05). The areas under the curves for serum iron for the different compounds gave AUCFS > AUCC = AUCIP1 = AUCIP2 = AUCIPD. Conclusions: The iron peptide complex did not increase blood iron FS C IP1 IP2 IPD concentration as compared to control and ferrous sulfate at the respective time points.MetaScience Press2022-01-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed Articleapplication/pdfhttps://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/3510.1055/s-0040-1701408International Journal of Nutrology; Vol. 4 No. 3 (2011): International Journal of Nutrology (IJN) - December 2011; 41-452595-28541984-301110.1055/s-010-45519reponame:International Journal of Nutrology (Online)instname:Associação Brasileira de Nutrologia (ABRAN)instacron:ABRANenghttps://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/35/32Copyright (c) 2022 International Journal of Nutrologyinfo:eu-repo/semantics/openAccessSakamoto, Luiz MaçaoHotta, Júlia Keiko SakamotoMáximo, Aparecida de FátimaUnamuno, Maria do Rosário Del LamaFerreira, Jacob FernandoSuen, Vivian Marques MiguelMarchini, Júlio Sérgio2022-01-24T18:44:13Zoai:ojs2.ijn.zotarellifilhoscientificworks.com:article/35Revistahttps://ijn.zotarellifilhoscientificworks.com/index.php/ijnONGhttps://ijn.zotarellifilhoscientificworks.com/index.php/ijn/oaiijn@zotarellifilhoscientificworks.com || editorchief@zotarellifilhoscientificworks.com10.544482595-28541984-3011opendoar:2022-01-24T18:44:13International Journal of Nutrology (Online) - Associação Brasileira de Nutrologia (ABRAN)false |
dc.title.none.fl_str_mv |
Iron peptide complex does not increase blood iron concentration at the same extent as ferrous sulfate after oral ingestion in healthy adult males |
title |
Iron peptide complex does not increase blood iron concentration at the same extent as ferrous sulfate after oral ingestion in healthy adult males |
spellingShingle |
Iron peptide complex does not increase blood iron concentration at the same extent as ferrous sulfate after oral ingestion in healthy adult males Sakamoto, Luiz Maçao Ferrous sulfate iron-peptide complex serum iron anemia iron deficiency |
title_short |
Iron peptide complex does not increase blood iron concentration at the same extent as ferrous sulfate after oral ingestion in healthy adult males |
title_full |
Iron peptide complex does not increase blood iron concentration at the same extent as ferrous sulfate after oral ingestion in healthy adult males |
title_fullStr |
Iron peptide complex does not increase blood iron concentration at the same extent as ferrous sulfate after oral ingestion in healthy adult males |
title_full_unstemmed |
Iron peptide complex does not increase blood iron concentration at the same extent as ferrous sulfate after oral ingestion in healthy adult males |
title_sort |
Iron peptide complex does not increase blood iron concentration at the same extent as ferrous sulfate after oral ingestion in healthy adult males |
author |
Sakamoto, Luiz Maçao |
author_facet |
Sakamoto, Luiz Maçao Hotta, Júlia Keiko Sakamoto Máximo, Aparecida de Fátima Unamuno, Maria do Rosário Del Lama Ferreira, Jacob Fernando Suen, Vivian Marques Miguel Marchini, Júlio Sérgio |
author_role |
author |
author2 |
Hotta, Júlia Keiko Sakamoto Máximo, Aparecida de Fátima Unamuno, Maria do Rosário Del Lama Ferreira, Jacob Fernando Suen, Vivian Marques Miguel Marchini, Júlio Sérgio |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Sakamoto, Luiz Maçao Hotta, Júlia Keiko Sakamoto Máximo, Aparecida de Fátima Unamuno, Maria do Rosário Del Lama Ferreira, Jacob Fernando Suen, Vivian Marques Miguel Marchini, Júlio Sérgio |
dc.subject.por.fl_str_mv |
Ferrous sulfate iron-peptide complex serum iron anemia iron deficiency |
topic |
Ferrous sulfate iron-peptide complex serum iron anemia iron deficiency |
description |
Iron-deficient anemia continues to be one of the major nutritional and public health problems all over the world. Although ferrous sulfate is largely used for the prevention and treatment of this deficiency, the gastrointestinal side effects preclude its use in some cases. This study aimed to compare the effect of iron peptide complex and ferrous sulfate on serum iron and to examine serial serum iron levels. Ten volunteers were submitted to 5 different treatments: Control (C), Ferrous sulfate 60 mg (FS), Iron peptide 60 mg (IP1), Iron peptide 80 mg (IP2) and Iron peptide 60 mg plus diet (IPD). In the first treatment (C), empty capsules were given, whereas in the second (FS), third (IP1), fourth (IP2) and fifth (IPD) treatments, ferrous sulfate 60 mg, iron peptide complex 60 mg, iron peptide complex 80 mg and iron peptide complex 60 mg plus diet were given in a randomized crossover design, with a washout period of 1 week. The products were offered as capsules and blood samples were drawn at the following time points: 0, 30, 60, 120, 240, 480 and 720 minutes after oral intake. FS produced higher serum iron levels than Control, IP1, IP2 and IPD (P< 0.05). The areas under the curves for serum iron for the different compounds gave AUCFS > AUCC = AUCIP1 = AUCIP2 = AUCIPD. Conclusions: The iron peptide complex did not increase blood iron FS C IP1 IP2 IPD concentration as compared to control and ferrous sulfate at the respective time points. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-24 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/35 10.1055/s-0040-1701408 |
url |
https://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/35 |
identifier_str_mv |
10.1055/s-0040-1701408 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/35/32 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 International Journal of Nutrology info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 International Journal of Nutrology |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MetaScience Press |
publisher.none.fl_str_mv |
MetaScience Press |
dc.source.none.fl_str_mv |
International Journal of Nutrology; Vol. 4 No. 3 (2011): International Journal of Nutrology (IJN) - December 2011; 41-45 2595-2854 1984-3011 10.1055/s-010-45519 reponame:International Journal of Nutrology (Online) instname:Associação Brasileira de Nutrologia (ABRAN) instacron:ABRAN |
instname_str |
Associação Brasileira de Nutrologia (ABRAN) |
instacron_str |
ABRAN |
institution |
ABRAN |
reponame_str |
International Journal of Nutrology (Online) |
collection |
International Journal of Nutrology (Online) |
repository.name.fl_str_mv |
International Journal of Nutrology (Online) - Associação Brasileira de Nutrologia (ABRAN) |
repository.mail.fl_str_mv |
ijn@zotarellifilhoscientificworks.com || editorchief@zotarellifilhoscientificworks.com |
_version_ |
1792204587675942912 |