Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Ciência & Saúde Coletiva (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232018001103535 |
Resumo: | Abstract The gold rush in the Amazon Region caused an increase of mercury (Hg) levels in the environment, and, consequently, raised human exposure. Once released into aquatic systems, Hg could generate methylmercury (MeHg), an extremely toxic compound, which is accumulated through trophic chains. Several studies have provided evidences of the brain sensitivity to MeHg, as well as, of the fetus vulnerability during pregnancy. The main objective of this study was to estimate the Mild Mental Retardation (MMR) in Amazonian populations, caused by prenatal exposure to MeHg, using the methodology proposed by Poulin (2008), which quantifies the environmental burden of disease. The estimates of the MMR burden, attributed to prenatal MeHg exposure, were based on the calculation of Disability-Adjusted Life Years (DALY), which were obtained from MMR incidence rate in the studied populations. At the local level, the MMR incidence rate calculations were based on primary data of MeHg exposure of riverine women at childbearing age. The MMR incidence rate was equal to 5.96/1,000 infants, which would result in 2.0 IQ points loss in 34.31% of the newborns. The estimated DALY/1,000 infants was equal to 71.2, while the DALY was 576. For the regional estimates, different exposure scenarios were created. The calculated DALY varied from 3,256 to 65,952 per year. |
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Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimatesHgDALYAmazonAbstract The gold rush in the Amazon Region caused an increase of mercury (Hg) levels in the environment, and, consequently, raised human exposure. Once released into aquatic systems, Hg could generate methylmercury (MeHg), an extremely toxic compound, which is accumulated through trophic chains. Several studies have provided evidences of the brain sensitivity to MeHg, as well as, of the fetus vulnerability during pregnancy. The main objective of this study was to estimate the Mild Mental Retardation (MMR) in Amazonian populations, caused by prenatal exposure to MeHg, using the methodology proposed by Poulin (2008), which quantifies the environmental burden of disease. The estimates of the MMR burden, attributed to prenatal MeHg exposure, were based on the calculation of Disability-Adjusted Life Years (DALY), which were obtained from MMR incidence rate in the studied populations. At the local level, the MMR incidence rate calculations were based on primary data of MeHg exposure of riverine women at childbearing age. The MMR incidence rate was equal to 5.96/1,000 infants, which would result in 2.0 IQ points loss in 34.31% of the newborns. The estimated DALY/1,000 infants was equal to 71.2, while the DALY was 576. For the regional estimates, different exposure scenarios were created. The calculated DALY varied from 3,256 to 65,952 per year.ABRASCO - Associação Brasileira de Saúde Coletiva2018-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232018001103535Ciência & Saúde Coletiva v.23 n.11 2018reponame:Ciência & Saúde Coletiva (Online)instname:Associação Brasileira de Saúde Coletiva (ABRASCO)instacron:ABRASCO10.1590/1413-812320182311.15812016info:eu-repo/semantics/openAccessVasconcellos,Ana Claudia Santiago deBarrocas,Paulo Rubens GuimarãesRuiz,Claudia Maribel VegaMourão,Dennys de SouzaHacon,Sandra de Souzaeng2018-11-26T00:00:00Zoai:scielo:S1413-81232018001103535Revistahttp://www.cienciaesaudecoletiva.com.brhttps://old.scielo.br/oai/scielo-oai.php||cienciasaudecoletiva@fiocruz.br1678-45611413-8123opendoar:2018-11-26T00:00Ciência & Saúde Coletiva (Online) - Associação Brasileira de Saúde Coletiva (ABRASCO)false |
dc.title.none.fl_str_mv |
Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates |
title |
Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates |
spellingShingle |
Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates Vasconcellos,Ana Claudia Santiago de Hg DALY Amazon |
title_short |
Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates |
title_full |
Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates |
title_fullStr |
Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates |
title_full_unstemmed |
Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates |
title_sort |
Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates |
author |
Vasconcellos,Ana Claudia Santiago de |
author_facet |
Vasconcellos,Ana Claudia Santiago de Barrocas,Paulo Rubens Guimarães Ruiz,Claudia Maribel Vega Mourão,Dennys de Souza Hacon,Sandra de Souza |
author_role |
author |
author2 |
Barrocas,Paulo Rubens Guimarães Ruiz,Claudia Maribel Vega Mourão,Dennys de Souza Hacon,Sandra de Souza |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Vasconcellos,Ana Claudia Santiago de Barrocas,Paulo Rubens Guimarães Ruiz,Claudia Maribel Vega Mourão,Dennys de Souza Hacon,Sandra de Souza |
dc.subject.por.fl_str_mv |
Hg DALY Amazon |
topic |
Hg DALY Amazon |
description |
Abstract The gold rush in the Amazon Region caused an increase of mercury (Hg) levels in the environment, and, consequently, raised human exposure. Once released into aquatic systems, Hg could generate methylmercury (MeHg), an extremely toxic compound, which is accumulated through trophic chains. Several studies have provided evidences of the brain sensitivity to MeHg, as well as, of the fetus vulnerability during pregnancy. The main objective of this study was to estimate the Mild Mental Retardation (MMR) in Amazonian populations, caused by prenatal exposure to MeHg, using the methodology proposed by Poulin (2008), which quantifies the environmental burden of disease. The estimates of the MMR burden, attributed to prenatal MeHg exposure, were based on the calculation of Disability-Adjusted Life Years (DALY), which were obtained from MMR incidence rate in the studied populations. At the local level, the MMR incidence rate calculations were based on primary data of MeHg exposure of riverine women at childbearing age. The MMR incidence rate was equal to 5.96/1,000 infants, which would result in 2.0 IQ points loss in 34.31% of the newborns. The estimated DALY/1,000 infants was equal to 71.2, while the DALY was 576. For the regional estimates, different exposure scenarios were created. The calculated DALY varied from 3,256 to 65,952 per year. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232018001103535 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232018001103535 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1413-812320182311.15812016 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
ABRASCO - Associação Brasileira de Saúde Coletiva |
publisher.none.fl_str_mv |
ABRASCO - Associação Brasileira de Saúde Coletiva |
dc.source.none.fl_str_mv |
Ciência & Saúde Coletiva v.23 n.11 2018 reponame:Ciência & Saúde Coletiva (Online) instname:Associação Brasileira de Saúde Coletiva (ABRASCO) instacron:ABRASCO |
instname_str |
Associação Brasileira de Saúde Coletiva (ABRASCO) |
instacron_str |
ABRASCO |
institution |
ABRASCO |
reponame_str |
Ciência & Saúde Coletiva (Online) |
collection |
Ciência & Saúde Coletiva (Online) |
repository.name.fl_str_mv |
Ciência & Saúde Coletiva (Online) - Associação Brasileira de Saúde Coletiva (ABRASCO) |
repository.mail.fl_str_mv |
||cienciasaudecoletiva@fiocruz.br |
_version_ |
1754213042645630976 |