Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates

Detalhes bibliográficos
Autor(a) principal: Vasconcellos,Ana Claudia Santiago de
Data de Publicação: 2018
Outros Autores: Barrocas,Paulo Rubens Guimarães, Ruiz,Claudia Maribel Vega, Mourão,Dennys de Souza, Hacon,Sandra de Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Ciência & Saúde Coletiva (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232018001103535
Resumo: Abstract The gold rush in the Amazon Region caused an increase of mercury (Hg) levels in the environment, and, consequently, raised human exposure. Once released into aquatic systems, Hg could generate methylmercury (MeHg), an extremely toxic compound, which is accumulated through trophic chains. Several studies have provided evidences of the brain sensitivity to MeHg, as well as, of the fetus vulnerability during pregnancy. The main objective of this study was to estimate the Mild Mental Retardation (MMR) in Amazonian populations, caused by prenatal exposure to MeHg, using the methodology proposed by Poulin (2008), which quantifies the environmental burden of disease. The estimates of the MMR burden, attributed to prenatal MeHg exposure, were based on the calculation of Disability-Adjusted Life Years (DALY), which were obtained from MMR incidence rate in the studied populations. At the local level, the MMR incidence rate calculations were based on primary data of MeHg exposure of riverine women at childbearing age. The MMR incidence rate was equal to 5.96/1,000 infants, which would result in 2.0 IQ points loss in 34.31% of the newborns. The estimated DALY/1,000 infants was equal to 71.2, while the DALY was 576. For the regional estimates, different exposure scenarios were created. The calculated DALY varied from 3,256 to 65,952 per year.
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spelling Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimatesHgDALYAmazonAbstract The gold rush in the Amazon Region caused an increase of mercury (Hg) levels in the environment, and, consequently, raised human exposure. Once released into aquatic systems, Hg could generate methylmercury (MeHg), an extremely toxic compound, which is accumulated through trophic chains. Several studies have provided evidences of the brain sensitivity to MeHg, as well as, of the fetus vulnerability during pregnancy. The main objective of this study was to estimate the Mild Mental Retardation (MMR) in Amazonian populations, caused by prenatal exposure to MeHg, using the methodology proposed by Poulin (2008), which quantifies the environmental burden of disease. The estimates of the MMR burden, attributed to prenatal MeHg exposure, were based on the calculation of Disability-Adjusted Life Years (DALY), which were obtained from MMR incidence rate in the studied populations. At the local level, the MMR incidence rate calculations were based on primary data of MeHg exposure of riverine women at childbearing age. The MMR incidence rate was equal to 5.96/1,000 infants, which would result in 2.0 IQ points loss in 34.31% of the newborns. The estimated DALY/1,000 infants was equal to 71.2, while the DALY was 576. For the regional estimates, different exposure scenarios were created. The calculated DALY varied from 3,256 to 65,952 per year.ABRASCO - Associação Brasileira de Saúde Coletiva2018-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232018001103535Ciência & Saúde Coletiva v.23 n.11 2018reponame:Ciência & Saúde Coletiva (Online)instname:Associação Brasileira de Saúde Coletiva (ABRASCO)instacron:ABRASCO10.1590/1413-812320182311.15812016info:eu-repo/semantics/openAccessVasconcellos,Ana Claudia Santiago deBarrocas,Paulo Rubens GuimarãesRuiz,Claudia Maribel VegaMourão,Dennys de SouzaHacon,Sandra de Souzaeng2018-11-26T00:00:00Zoai:scielo:S1413-81232018001103535Revistahttp://www.cienciaesaudecoletiva.com.brhttps://old.scielo.br/oai/scielo-oai.php||cienciasaudecoletiva@fiocruz.br1678-45611413-8123opendoar:2018-11-26T00:00Ciência & Saúde Coletiva (Online) - Associação Brasileira de Saúde Coletiva (ABRASCO)false
dc.title.none.fl_str_mv Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates
title Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates
spellingShingle Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates
Vasconcellos,Ana Claudia Santiago de
Hg
DALY
Amazon
title_short Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates
title_full Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates
title_fullStr Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates
title_full_unstemmed Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates
title_sort Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates
author Vasconcellos,Ana Claudia Santiago de
author_facet Vasconcellos,Ana Claudia Santiago de
Barrocas,Paulo Rubens Guimarães
Ruiz,Claudia Maribel Vega
Mourão,Dennys de Souza
Hacon,Sandra de Souza
author_role author
author2 Barrocas,Paulo Rubens Guimarães
Ruiz,Claudia Maribel Vega
Mourão,Dennys de Souza
Hacon,Sandra de Souza
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Vasconcellos,Ana Claudia Santiago de
Barrocas,Paulo Rubens Guimarães
Ruiz,Claudia Maribel Vega
Mourão,Dennys de Souza
Hacon,Sandra de Souza
dc.subject.por.fl_str_mv Hg
DALY
Amazon
topic Hg
DALY
Amazon
description Abstract The gold rush in the Amazon Region caused an increase of mercury (Hg) levels in the environment, and, consequently, raised human exposure. Once released into aquatic systems, Hg could generate methylmercury (MeHg), an extremely toxic compound, which is accumulated through trophic chains. Several studies have provided evidences of the brain sensitivity to MeHg, as well as, of the fetus vulnerability during pregnancy. The main objective of this study was to estimate the Mild Mental Retardation (MMR) in Amazonian populations, caused by prenatal exposure to MeHg, using the methodology proposed by Poulin (2008), which quantifies the environmental burden of disease. The estimates of the MMR burden, attributed to prenatal MeHg exposure, were based on the calculation of Disability-Adjusted Life Years (DALY), which were obtained from MMR incidence rate in the studied populations. At the local level, the MMR incidence rate calculations were based on primary data of MeHg exposure of riverine women at childbearing age. The MMR incidence rate was equal to 5.96/1,000 infants, which would result in 2.0 IQ points loss in 34.31% of the newborns. The estimated DALY/1,000 infants was equal to 71.2, while the DALY was 576. For the regional estimates, different exposure scenarios were created. The calculated DALY varied from 3,256 to 65,952 per year.
publishDate 2018
dc.date.none.fl_str_mv 2018-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232018001103535
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dc.relation.none.fl_str_mv 10.1590/1413-812320182311.15812016
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dc.publisher.none.fl_str_mv ABRASCO - Associação Brasileira de Saúde Coletiva
publisher.none.fl_str_mv ABRASCO - Associação Brasileira de Saúde Coletiva
dc.source.none.fl_str_mv Ciência & Saúde Coletiva v.23 n.11 2018
reponame:Ciência & Saúde Coletiva (Online)
instname:Associação Brasileira de Saúde Coletiva (ABRASCO)
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repository.name.fl_str_mv Ciência & Saúde Coletiva (Online) - Associação Brasileira de Saúde Coletiva (ABRASCO)
repository.mail.fl_str_mv ||cienciasaudecoletiva@fiocruz.br
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