Low serum testosterone is a predictor of high-grade disease in patients with prostate cancer
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000800704 |
Resumo: | Summary Objective: To evaluate the relation between serum total testosterone (TT) and prostate cancer (PCa) grade and the effect of race and demographic characteristics on such association. Method: We analyzed 695 patients undergoing radical prostatectomy (RP), of whom 423 had serum TT collected. Patients were classified as having hypogonadism or eugonadism based on two thresholds of testosterone: threshold 1 (300 ng/dL) and threshold 2 (250 ng/dL). We evaluated the relation between TT levels and a Gleason score (GS) ≥ 7 in RP specimens. Outcomes were evaluated using univariate and multivariate analyses, accounting for race and other demographic predictors. Results: Out of 423 patients, 37.8% had hypogonadism based on the threshold 1 and 23.9% based on the threshold 2. Patients with hypogonadism, in both thresholds, had a higher chance of GS ≥ 7 (OR 1.79, p=0.02 and OR 2.08, p=0.012, respectively). In the multivariate analysis, adjusted for age, TT, body mass index (BMI) and race, low TT (p=0.023) and age (p=0.002) were found to be independent risk factors for GS ≥ 7. Among Black individuals, low serum TT was a stronger predictor of high-grade disease compared to White men (p=0.02). Conclusion: Hypogonadism is independently associated to higher GS in localized PCa. The effect of this association is significantly more pronounced among Black men and could partly explain aggressive characteristics of PCa found in this race. |
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Low serum testosterone is a predictor of high-grade disease in patients with prostate cancerprostate cancerhypogonadismtestosteroneSummary Objective: To evaluate the relation between serum total testosterone (TT) and prostate cancer (PCa) grade and the effect of race and demographic characteristics on such association. Method: We analyzed 695 patients undergoing radical prostatectomy (RP), of whom 423 had serum TT collected. Patients were classified as having hypogonadism or eugonadism based on two thresholds of testosterone: threshold 1 (300 ng/dL) and threshold 2 (250 ng/dL). We evaluated the relation between TT levels and a Gleason score (GS) ≥ 7 in RP specimens. Outcomes were evaluated using univariate and multivariate analyses, accounting for race and other demographic predictors. Results: Out of 423 patients, 37.8% had hypogonadism based on the threshold 1 and 23.9% based on the threshold 2. Patients with hypogonadism, in both thresholds, had a higher chance of GS ≥ 7 (OR 1.79, p=0.02 and OR 2.08, p=0.012, respectively). In the multivariate analysis, adjusted for age, TT, body mass index (BMI) and race, low TT (p=0.023) and age (p=0.002) were found to be independent risk factors for GS ≥ 7. Among Black individuals, low serum TT was a stronger predictor of high-grade disease compared to White men (p=0.02). Conclusion: Hypogonadism is independently associated to higher GS in localized PCa. The effect of this association is significantly more pronounced among Black men and could partly explain aggressive characteristics of PCa found in this race.Associação Médica Brasileira2017-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000800704Revista da Associação Médica Brasileira v.63 n.8 2017reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.63.08.704info:eu-repo/semantics/openAccessAlbuquerque,George A. M. Lins deGuglielmetti,Giuliano B.Barbosa,João Arthur B. A.Pontes Jr.,JoséFazoli,Arnaldo J. C.Cordeiro,Maurício D.Coelho,Rafael F.Carvalho,Paulo Afonso deGallucci,Fábio P.Padovani,Guilherme P.Park,RubensCury,JoséNonemacher,HenriqueSrougi,MiguelNahas,William C.eng2017-09-27T00:00:00Zoai:scielo:S0104-42302017000800704Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2017-09-27T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Low serum testosterone is a predictor of high-grade disease in patients with prostate cancer |
title |
Low serum testosterone is a predictor of high-grade disease in patients with prostate cancer |
spellingShingle |
Low serum testosterone is a predictor of high-grade disease in patients with prostate cancer Albuquerque,George A. M. Lins de prostate cancer hypogonadism testosterone |
title_short |
Low serum testosterone is a predictor of high-grade disease in patients with prostate cancer |
title_full |
Low serum testosterone is a predictor of high-grade disease in patients with prostate cancer |
title_fullStr |
Low serum testosterone is a predictor of high-grade disease in patients with prostate cancer |
title_full_unstemmed |
Low serum testosterone is a predictor of high-grade disease in patients with prostate cancer |
title_sort |
Low serum testosterone is a predictor of high-grade disease in patients with prostate cancer |
author |
Albuquerque,George A. M. Lins de |
author_facet |
Albuquerque,George A. M. Lins de Guglielmetti,Giuliano B. Barbosa,João Arthur B. A. Pontes Jr.,José Fazoli,Arnaldo J. C. Cordeiro,Maurício D. Coelho,Rafael F. Carvalho,Paulo Afonso de Gallucci,Fábio P. Padovani,Guilherme P. Park,Rubens Cury,José Nonemacher,Henrique Srougi,Miguel Nahas,William C. |
author_role |
author |
author2 |
Guglielmetti,Giuliano B. Barbosa,João Arthur B. A. Pontes Jr.,José Fazoli,Arnaldo J. C. Cordeiro,Maurício D. Coelho,Rafael F. Carvalho,Paulo Afonso de Gallucci,Fábio P. Padovani,Guilherme P. Park,Rubens Cury,José Nonemacher,Henrique Srougi,Miguel Nahas,William C. |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Albuquerque,George A. M. Lins de Guglielmetti,Giuliano B. Barbosa,João Arthur B. A. Pontes Jr.,José Fazoli,Arnaldo J. C. Cordeiro,Maurício D. Coelho,Rafael F. Carvalho,Paulo Afonso de Gallucci,Fábio P. Padovani,Guilherme P. Park,Rubens Cury,José Nonemacher,Henrique Srougi,Miguel Nahas,William C. |
dc.subject.por.fl_str_mv |
prostate cancer hypogonadism testosterone |
topic |
prostate cancer hypogonadism testosterone |
description |
Summary Objective: To evaluate the relation between serum total testosterone (TT) and prostate cancer (PCa) grade and the effect of race and demographic characteristics on such association. Method: We analyzed 695 patients undergoing radical prostatectomy (RP), of whom 423 had serum TT collected. Patients were classified as having hypogonadism or eugonadism based on two thresholds of testosterone: threshold 1 (300 ng/dL) and threshold 2 (250 ng/dL). We evaluated the relation between TT levels and a Gleason score (GS) ≥ 7 in RP specimens. Outcomes were evaluated using univariate and multivariate analyses, accounting for race and other demographic predictors. Results: Out of 423 patients, 37.8% had hypogonadism based on the threshold 1 and 23.9% based on the threshold 2. Patients with hypogonadism, in both thresholds, had a higher chance of GS ≥ 7 (OR 1.79, p=0.02 and OR 2.08, p=0.012, respectively). In the multivariate analysis, adjusted for age, TT, body mass index (BMI) and race, low TT (p=0.023) and age (p=0.002) were found to be independent risk factors for GS ≥ 7. Among Black individuals, low serum TT was a stronger predictor of high-grade disease compared to White men (p=0.02). Conclusion: Hypogonadism is independently associated to higher GS in localized PCa. The effect of this association is significantly more pronounced among Black men and could partly explain aggressive characteristics of PCa found in this race. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000800704 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000800704 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-9282.63.08.704 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.63 n.8 2017 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
institution |
AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
repository.mail.fl_str_mv |
||ramb@amb.org.br |
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1754212832936722432 |