Disease-free survival in patients with non-metastatic breast cancer

Detalhes bibliográficos
Autor(a) principal: Diniz,Roberta Wolp
Data de Publicação: 2016
Outros Autores: Guerra,Maximiliano Ribeiro, Cintra,Jane Rocha Duarte, Fayer,Vívian Assis, Teixeira,Maria Teresa Bustamante
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Associação Médica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016000500407
Resumo: SUMMARY Introduction: Breast cancer is the second most common malignancy in the world and the one with highest incidence in the female population; it is also a major cause of death from cancer among women. Objective: To analyze the disease-free survival (DFS) at 5 years and prognostic factors in women with non-metastatic invasive breast cancer treated at a referral center for cancer care located in a medium-sized city in the Southeast of Brazil. Method: Patients diagnosed with the disease between 2003 and 2005 and identified through the institution’s cancer hospital records were analyzed. The follow-up of cases was carried out through hospital records, and complemented by search in the database of the Mortality Information System (SIM) as well as telephone contact. The variables analyzed were distributed in the following blocks: socio-demographic data, tumor-related characteristics, and treatment-related characteristics. Survival functions were calculated using the Kaplan-Meier method and the prognostic factors were analyzed based on Cox proportional hazard model. Results: The study showed a DFS at 5 years of 72% (95CI 67.6-75.9). The main variables independently associated with DFS were lymph node involvement, use of hormone therapy, and education level. Conclusion: This study reinforces the importance of early diagnosis for DFS, pointing to the role of social aspects in this regard. The relevance of this research in the country is also highlighted, given the scarcity of studies on DFS in the Brazilian population.
id AMB-1_36810e429a55f33d081574dda5db4b79
oai_identifier_str oai:scielo:S0104-42302016000500407
network_acronym_str AMB-1
network_name_str Revista da Associação Médica Brasileira (Online)
repository_id_str
spelling Disease-free survival in patients with non-metastatic breast cancerbreast neoplasm’ssurvival analysissurvivalSUMMARY Introduction: Breast cancer is the second most common malignancy in the world and the one with highest incidence in the female population; it is also a major cause of death from cancer among women. Objective: To analyze the disease-free survival (DFS) at 5 years and prognostic factors in women with non-metastatic invasive breast cancer treated at a referral center for cancer care located in a medium-sized city in the Southeast of Brazil. Method: Patients diagnosed with the disease between 2003 and 2005 and identified through the institution’s cancer hospital records were analyzed. The follow-up of cases was carried out through hospital records, and complemented by search in the database of the Mortality Information System (SIM) as well as telephone contact. The variables analyzed were distributed in the following blocks: socio-demographic data, tumor-related characteristics, and treatment-related characteristics. Survival functions were calculated using the Kaplan-Meier method and the prognostic factors were analyzed based on Cox proportional hazard model. Results: The study showed a DFS at 5 years of 72% (95CI 67.6-75.9). The main variables independently associated with DFS were lymph node involvement, use of hormone therapy, and education level. Conclusion: This study reinforces the importance of early diagnosis for DFS, pointing to the role of social aspects in this regard. The relevance of this research in the country is also highlighted, given the scarcity of studies on DFS in the Brazilian population.Associação Médica Brasileira2016-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016000500407Revista da Associação Médica Brasileira v.62 n.5 2016reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.62.05.407info:eu-repo/semantics/openAccessDiniz,Roberta WolpGuerra,Maximiliano RibeiroCintra,Jane Rocha DuarteFayer,Vívian AssisTeixeira,Maria Teresa Bustamanteeng2016-10-04T00:00:00Zoai:scielo:S0104-42302016000500407Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2016-10-04T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false
dc.title.none.fl_str_mv Disease-free survival in patients with non-metastatic breast cancer
title Disease-free survival in patients with non-metastatic breast cancer
spellingShingle Disease-free survival in patients with non-metastatic breast cancer
Diniz,Roberta Wolp
breast neoplasm’s
survival analysis
survival
title_short Disease-free survival in patients with non-metastatic breast cancer
title_full Disease-free survival in patients with non-metastatic breast cancer
title_fullStr Disease-free survival in patients with non-metastatic breast cancer
title_full_unstemmed Disease-free survival in patients with non-metastatic breast cancer
title_sort Disease-free survival in patients with non-metastatic breast cancer
author Diniz,Roberta Wolp
author_facet Diniz,Roberta Wolp
Guerra,Maximiliano Ribeiro
Cintra,Jane Rocha Duarte
Fayer,Vívian Assis
Teixeira,Maria Teresa Bustamante
author_role author
author2 Guerra,Maximiliano Ribeiro
Cintra,Jane Rocha Duarte
Fayer,Vívian Assis
Teixeira,Maria Teresa Bustamante
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Diniz,Roberta Wolp
Guerra,Maximiliano Ribeiro
Cintra,Jane Rocha Duarte
Fayer,Vívian Assis
Teixeira,Maria Teresa Bustamante
dc.subject.por.fl_str_mv breast neoplasm’s
survival analysis
survival
topic breast neoplasm’s
survival analysis
survival
description SUMMARY Introduction: Breast cancer is the second most common malignancy in the world and the one with highest incidence in the female population; it is also a major cause of death from cancer among women. Objective: To analyze the disease-free survival (DFS) at 5 years and prognostic factors in women with non-metastatic invasive breast cancer treated at a referral center for cancer care located in a medium-sized city in the Southeast of Brazil. Method: Patients diagnosed with the disease between 2003 and 2005 and identified through the institution’s cancer hospital records were analyzed. The follow-up of cases was carried out through hospital records, and complemented by search in the database of the Mortality Information System (SIM) as well as telephone contact. The variables analyzed were distributed in the following blocks: socio-demographic data, tumor-related characteristics, and treatment-related characteristics. Survival functions were calculated using the Kaplan-Meier method and the prognostic factors were analyzed based on Cox proportional hazard model. Results: The study showed a DFS at 5 years of 72% (95CI 67.6-75.9). The main variables independently associated with DFS were lymph node involvement, use of hormone therapy, and education level. Conclusion: This study reinforces the importance of early diagnosis for DFS, pointing to the role of social aspects in this regard. The relevance of this research in the country is also highlighted, given the scarcity of studies on DFS in the Brazilian population.
publishDate 2016
dc.date.none.fl_str_mv 2016-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016000500407
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016000500407
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1806-9282.62.05.407
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Médica Brasileira
publisher.none.fl_str_mv Associação Médica Brasileira
dc.source.none.fl_str_mv Revista da Associação Médica Brasileira v.62 n.5 2016
reponame:Revista da Associação Médica Brasileira (Online)
instname:Associação Médica Brasileira (AMB)
instacron:AMB
instname_str Associação Médica Brasileira (AMB)
instacron_str AMB
institution AMB
reponame_str Revista da Associação Médica Brasileira (Online)
collection Revista da Associação Médica Brasileira (Online)
repository.name.fl_str_mv Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)
repository.mail.fl_str_mv ||ramb@amb.org.br
_version_ 1754212831964692480