Potentially inappropriate medications based on TIME criteria and risk of in-hospital mortality in COVID-19 patients
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302022001201730 |
Resumo: | SUMMARY OBJECTIVE: This study aimed to evaluate the relationship between hospital admission potentially inappropriate medications use (PIM) and in-hospital mortality of COVID-19, considering other possible factors related to mortality. METHODS: The Turkish inappropriate medication use in the elderly (TIME) criteria were used to define PIM. The primary outcome of this study was in-hospital mortality. RESULTS: We included 201 older adults (mean age 73.1±9.4, 48.9% females). The in-hospital mortality rate and prevalence of PIM were 18.9% (n=38) and 96% (n=193), respectively. The most common PIM according to TIME to START was insufficient vitamin D and/or calcium intake per day. Proton-pump inhibitor use for multiple drug indications was the most prevalent PIM based on TIME to STOP findings. Mortality was related to PIM in univariate analysis (p=0.005) but not in multivariate analysis (p=0.599). Older age (hazards ratio (HR): 1.08; 95% confidence interval (CI): 1.02–1.13; p=0.005) and higher Nutritional Risk Screening 2002 (NRS-2002) scores were correlated with in-hospital mortality (HR: 1.29; 95%CI 1.00–1.65; p=0.042). CONCLUSION: Mortality was not associated with PIM. Older age and malnutrition were related to in-hospital mortality in COVID-19. |
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Potentially inappropriate medications based on TIME criteria and risk of in-hospital mortality in COVID-19 patientsCOVIDOlder adultPotentially inappropriate medication useCriteriaSUMMARY OBJECTIVE: This study aimed to evaluate the relationship between hospital admission potentially inappropriate medications use (PIM) and in-hospital mortality of COVID-19, considering other possible factors related to mortality. METHODS: The Turkish inappropriate medication use in the elderly (TIME) criteria were used to define PIM. The primary outcome of this study was in-hospital mortality. RESULTS: We included 201 older adults (mean age 73.1±9.4, 48.9% females). The in-hospital mortality rate and prevalence of PIM were 18.9% (n=38) and 96% (n=193), respectively. The most common PIM according to TIME to START was insufficient vitamin D and/or calcium intake per day. Proton-pump inhibitor use for multiple drug indications was the most prevalent PIM based on TIME to STOP findings. Mortality was related to PIM in univariate analysis (p=0.005) but not in multivariate analysis (p=0.599). Older age (hazards ratio (HR): 1.08; 95% confidence interval (CI): 1.02–1.13; p=0.005) and higher Nutritional Risk Screening 2002 (NRS-2002) scores were correlated with in-hospital mortality (HR: 1.29; 95%CI 1.00–1.65; p=0.042). CONCLUSION: Mortality was not associated with PIM. Older age and malnutrition were related to in-hospital mortality in COVID-19.Associação Médica Brasileira2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302022001201730Revista da Associação Médica Brasileira v.68 n.12 2022reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.20220907info:eu-repo/semantics/openAccessDurmuş,Nurdan ŞentürkTufan,AslıCan,BüşraOlgun,ŞehnazKocakaya,Deryaİlhan,BirkanBahat,Gülistaneng2022-12-13T00:00:00Zoai:scielo:S0104-42302022001201730Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2022-12-13T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Potentially inappropriate medications based on TIME criteria and risk of in-hospital mortality in COVID-19 patients |
title |
Potentially inappropriate medications based on TIME criteria and risk of in-hospital mortality in COVID-19 patients |
spellingShingle |
Potentially inappropriate medications based on TIME criteria and risk of in-hospital mortality in COVID-19 patients Durmuş,Nurdan Şentürk COVID Older adult Potentially inappropriate medication use Criteria |
title_short |
Potentially inappropriate medications based on TIME criteria and risk of in-hospital mortality in COVID-19 patients |
title_full |
Potentially inappropriate medications based on TIME criteria and risk of in-hospital mortality in COVID-19 patients |
title_fullStr |
Potentially inappropriate medications based on TIME criteria and risk of in-hospital mortality in COVID-19 patients |
title_full_unstemmed |
Potentially inappropriate medications based on TIME criteria and risk of in-hospital mortality in COVID-19 patients |
title_sort |
Potentially inappropriate medications based on TIME criteria and risk of in-hospital mortality in COVID-19 patients |
author |
Durmuş,Nurdan Şentürk |
author_facet |
Durmuş,Nurdan Şentürk Tufan,Aslı Can,Büşra Olgun,Şehnaz Kocakaya,Derya İlhan,Birkan Bahat,Gülistan |
author_role |
author |
author2 |
Tufan,Aslı Can,Büşra Olgun,Şehnaz Kocakaya,Derya İlhan,Birkan Bahat,Gülistan |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Durmuş,Nurdan Şentürk Tufan,Aslı Can,Büşra Olgun,Şehnaz Kocakaya,Derya İlhan,Birkan Bahat,Gülistan |
dc.subject.por.fl_str_mv |
COVID Older adult Potentially inappropriate medication use Criteria |
topic |
COVID Older adult Potentially inappropriate medication use Criteria |
description |
SUMMARY OBJECTIVE: This study aimed to evaluate the relationship between hospital admission potentially inappropriate medications use (PIM) and in-hospital mortality of COVID-19, considering other possible factors related to mortality. METHODS: The Turkish inappropriate medication use in the elderly (TIME) criteria were used to define PIM. The primary outcome of this study was in-hospital mortality. RESULTS: We included 201 older adults (mean age 73.1±9.4, 48.9% females). The in-hospital mortality rate and prevalence of PIM were 18.9% (n=38) and 96% (n=193), respectively. The most common PIM according to TIME to START was insufficient vitamin D and/or calcium intake per day. Proton-pump inhibitor use for multiple drug indications was the most prevalent PIM based on TIME to STOP findings. Mortality was related to PIM in univariate analysis (p=0.005) but not in multivariate analysis (p=0.599). Older age (hazards ratio (HR): 1.08; 95% confidence interval (CI): 1.02–1.13; p=0.005) and higher Nutritional Risk Screening 2002 (NRS-2002) scores were correlated with in-hospital mortality (HR: 1.29; 95%CI 1.00–1.65; p=0.042). CONCLUSION: Mortality was not associated with PIM. Older age and malnutrition were related to in-hospital mortality in COVID-19. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302022001201730 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302022001201730 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-9282.20220907 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.68 n.12 2022 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
institution |
AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
repository.mail.fl_str_mv |
||ramb@amb.org.br |
_version_ |
1754212838496272384 |