Comparison of clinical characteristics of wild-type SARS-CoV-2 and Omicron
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302022001001476 |
Resumo: | SUMMARY OBJECTIVE: This study aimed to investigate the effect of mutations by comparing wild-type SARS-CoV-2 and Omicron regarding clinical features in patients with COVID-19. It also aimed to assess whether SARS-CoV-2 cycle threshold value could predict COVID-19 severity. METHODS: A total of 960 wild-type and 411 Omicron variant patients with positive results in SARS-CoV-2 real-time reverse transcriptase polymerase chain reaction test from oropharyngeal and/or nasopharyngeal samples during their hospital admissions were included in this retrospective study. The reference symptoms of the patients were obtained from the hospital database. The correlation between chest computed tomography findings and the “cycle threshold” of patients with wild-type SARS-CoV-2 was assessed. RESULTS: Cough, fever, shortness of breath, loss of taste and smell, and diarrhea were found to be statistically significantly higher (p=0.001; 0.001; 0.001; 0.001; and 0.006; respectively) in the wild-type cohort, while in the Omicron cohort, sore throat and headache were found to be statistically significantly higher (p=0.001 and 0.003, respectively). An inverse relationship was found between chest computed tomography findings and viral load. CONCLUSION: This study revealed that the Omicron variant tended to infect predominantly the upper respiratory tract and showed decreased lung infectivity, and the disease progressed with a milder clinical course. Therefore, the study showed that the tropism of the virus was changed and the viral phenotype was affected. It was also found that SARS-CoV-2 viral load did not predict COVID-19 severity in patients with wild-type SARS-CoV-2. |
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Comparison of clinical characteristics of wild-type SARS-CoV-2 and OmicronCOVID-19SARS-CoV-2 variantsCoronavirusViral loadSUMMARY OBJECTIVE: This study aimed to investigate the effect of mutations by comparing wild-type SARS-CoV-2 and Omicron regarding clinical features in patients with COVID-19. It also aimed to assess whether SARS-CoV-2 cycle threshold value could predict COVID-19 severity. METHODS: A total of 960 wild-type and 411 Omicron variant patients with positive results in SARS-CoV-2 real-time reverse transcriptase polymerase chain reaction test from oropharyngeal and/or nasopharyngeal samples during their hospital admissions were included in this retrospective study. The reference symptoms of the patients were obtained from the hospital database. The correlation between chest computed tomography findings and the “cycle threshold” of patients with wild-type SARS-CoV-2 was assessed. RESULTS: Cough, fever, shortness of breath, loss of taste and smell, and diarrhea were found to be statistically significantly higher (p=0.001; 0.001; 0.001; 0.001; and 0.006; respectively) in the wild-type cohort, while in the Omicron cohort, sore throat and headache were found to be statistically significantly higher (p=0.001 and 0.003, respectively). An inverse relationship was found between chest computed tomography findings and viral load. CONCLUSION: This study revealed that the Omicron variant tended to infect predominantly the upper respiratory tract and showed decreased lung infectivity, and the disease progressed with a milder clinical course. Therefore, the study showed that the tropism of the virus was changed and the viral phenotype was affected. It was also found that SARS-CoV-2 viral load did not predict COVID-19 severity in patients with wild-type SARS-CoV-2.Associação Médica Brasileira2022-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302022001001476Revista da Associação Médica Brasileira v.68 n.10 2022reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.20220880info:eu-repo/semantics/openAccessKirca,FüsunAydoğan,SibelGözalan,AyşegülKayipmaz,Afşin EmreÖzdemir,Fatma Ayça EdisTekçe,Yasemin TezerBeşer,İpek OmayGün,PınarÖkten,Rıza SarperDinç,Bediaeng2022-11-11T00:00:00Zoai:scielo:S0104-42302022001001476Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2022-11-11T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Comparison of clinical characteristics of wild-type SARS-CoV-2 and Omicron |
title |
Comparison of clinical characteristics of wild-type SARS-CoV-2 and Omicron |
spellingShingle |
Comparison of clinical characteristics of wild-type SARS-CoV-2 and Omicron Kirca,Füsun COVID-19 SARS-CoV-2 variants Coronavirus Viral load |
title_short |
Comparison of clinical characteristics of wild-type SARS-CoV-2 and Omicron |
title_full |
Comparison of clinical characteristics of wild-type SARS-CoV-2 and Omicron |
title_fullStr |
Comparison of clinical characteristics of wild-type SARS-CoV-2 and Omicron |
title_full_unstemmed |
Comparison of clinical characteristics of wild-type SARS-CoV-2 and Omicron |
title_sort |
Comparison of clinical characteristics of wild-type SARS-CoV-2 and Omicron |
author |
Kirca,Füsun |
author_facet |
Kirca,Füsun Aydoğan,Sibel Gözalan,Ayşegül Kayipmaz,Afşin Emre Özdemir,Fatma Ayça Edis Tekçe,Yasemin Tezer Beşer,İpek Omay Gün,Pınar Ökten,Rıza Sarper Dinç,Bedia |
author_role |
author |
author2 |
Aydoğan,Sibel Gözalan,Ayşegül Kayipmaz,Afşin Emre Özdemir,Fatma Ayça Edis Tekçe,Yasemin Tezer Beşer,İpek Omay Gün,Pınar Ökten,Rıza Sarper Dinç,Bedia |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Kirca,Füsun Aydoğan,Sibel Gözalan,Ayşegül Kayipmaz,Afşin Emre Özdemir,Fatma Ayça Edis Tekçe,Yasemin Tezer Beşer,İpek Omay Gün,Pınar Ökten,Rıza Sarper Dinç,Bedia |
dc.subject.por.fl_str_mv |
COVID-19 SARS-CoV-2 variants Coronavirus Viral load |
topic |
COVID-19 SARS-CoV-2 variants Coronavirus Viral load |
description |
SUMMARY OBJECTIVE: This study aimed to investigate the effect of mutations by comparing wild-type SARS-CoV-2 and Omicron regarding clinical features in patients with COVID-19. It also aimed to assess whether SARS-CoV-2 cycle threshold value could predict COVID-19 severity. METHODS: A total of 960 wild-type and 411 Omicron variant patients with positive results in SARS-CoV-2 real-time reverse transcriptase polymerase chain reaction test from oropharyngeal and/or nasopharyngeal samples during their hospital admissions were included in this retrospective study. The reference symptoms of the patients were obtained from the hospital database. The correlation between chest computed tomography findings and the “cycle threshold” of patients with wild-type SARS-CoV-2 was assessed. RESULTS: Cough, fever, shortness of breath, loss of taste and smell, and diarrhea were found to be statistically significantly higher (p=0.001; 0.001; 0.001; 0.001; and 0.006; respectively) in the wild-type cohort, while in the Omicron cohort, sore throat and headache were found to be statistically significantly higher (p=0.001 and 0.003, respectively). An inverse relationship was found between chest computed tomography findings and viral load. CONCLUSION: This study revealed that the Omicron variant tended to infect predominantly the upper respiratory tract and showed decreased lung infectivity, and the disease progressed with a milder clinical course. Therefore, the study showed that the tropism of the virus was changed and the viral phenotype was affected. It was also found that SARS-CoV-2 viral load did not predict COVID-19 severity in patients with wild-type SARS-CoV-2. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302022001001476 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302022001001476 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-9282.20220880 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.68 n.10 2022 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
institution |
AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
repository.mail.fl_str_mv |
||ramb@amb.org.br |
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1754212838191136768 |