Cardiovascular complications in the acquired immunodeficiency syndrome
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Publication Date: | 2009 |
Other Authors: | |
Format: | Article |
Language: | eng |
Source: | Revista da Associação Médica Brasileira (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302009000500031 |
Summary: | The introduction of highly active antiretroviral therapy (HAART) has significantly improved the clinical outcome of HIV disease, with increased survival rates. However, the introduction of HAART has generated a contrast in the cardiac manifestations of AIDS. In developed countries, we observed an approximate 30% reduction in the prevalence of HIV-associated cardiomyopathy, possibly related to a reduction of opportunistic infections and myocarditis. In developing countries, however, where the availability of HAART is limited and the pathogenic impact of nutritional factors is significant, we observed an increase of approximately 32% in the prevalence of HIV-associated cardiomyopathy and a related high mortality rate from congestive heart failure. Also, some HAART regimens in developed countries, especially those including protease inhibitors, have been shown to cause, in a high proportion of HIV-infected patients, a iatrogenic metabolic syndrome (HIV-lipodystrophy syndrome).This is associated with an increased risk of atherosclerosis-related cardiovascular events even in young HIV-infected people. A better understanding of the molecular mechanisms responsible for this syndrome will lead to the discovery of new drugs that will reduce cardiovascular risk in HIV-infected patients receiving HAART. |
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Cardiovascular complications in the acquired immunodeficiency syndromeHIVAcquired Immunodeficiency SyndromeCardiovascular DiseasesHIV-Associated LipodystrophySyndrome Highly Active Antiretroviral TherapyThe introduction of highly active antiretroviral therapy (HAART) has significantly improved the clinical outcome of HIV disease, with increased survival rates. However, the introduction of HAART has generated a contrast in the cardiac manifestations of AIDS. In developed countries, we observed an approximate 30% reduction in the prevalence of HIV-associated cardiomyopathy, possibly related to a reduction of opportunistic infections and myocarditis. In developing countries, however, where the availability of HAART is limited and the pathogenic impact of nutritional factors is significant, we observed an increase of approximately 32% in the prevalence of HIV-associated cardiomyopathy and a related high mortality rate from congestive heart failure. Also, some HAART regimens in developed countries, especially those including protease inhibitors, have been shown to cause, in a high proportion of HIV-infected patients, a iatrogenic metabolic syndrome (HIV-lipodystrophy syndrome).This is associated with an increased risk of atherosclerosis-related cardiovascular events even in young HIV-infected people. A better understanding of the molecular mechanisms responsible for this syndrome will lead to the discovery of new drugs that will reduce cardiovascular risk in HIV-infected patients receiving HAART.Associação Médica Brasileira2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302009000500031Revista da Associação Médica Brasileira v.55 n.5 2009reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/S0104-42302009000500031info:eu-repo/semantics/openAccessBarbaro,GiuseppeSilva,Erika Ferrari Rafael daeng2009-11-17T00:00:00Zoai:scielo:S0104-42302009000500031Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2009-11-17T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Cardiovascular complications in the acquired immunodeficiency syndrome |
title |
Cardiovascular complications in the acquired immunodeficiency syndrome |
spellingShingle |
Cardiovascular complications in the acquired immunodeficiency syndrome Barbaro,Giuseppe HIV Acquired Immunodeficiency Syndrome Cardiovascular Diseases HIV-Associated Lipodystrophy Syndrome Highly Active Antiretroviral Therapy |
title_short |
Cardiovascular complications in the acquired immunodeficiency syndrome |
title_full |
Cardiovascular complications in the acquired immunodeficiency syndrome |
title_fullStr |
Cardiovascular complications in the acquired immunodeficiency syndrome |
title_full_unstemmed |
Cardiovascular complications in the acquired immunodeficiency syndrome |
title_sort |
Cardiovascular complications in the acquired immunodeficiency syndrome |
author |
Barbaro,Giuseppe |
author_facet |
Barbaro,Giuseppe Silva,Erika Ferrari Rafael da |
author_role |
author |
author2 |
Silva,Erika Ferrari Rafael da |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Barbaro,Giuseppe Silva,Erika Ferrari Rafael da |
dc.subject.por.fl_str_mv |
HIV Acquired Immunodeficiency Syndrome Cardiovascular Diseases HIV-Associated Lipodystrophy Syndrome Highly Active Antiretroviral Therapy |
topic |
HIV Acquired Immunodeficiency Syndrome Cardiovascular Diseases HIV-Associated Lipodystrophy Syndrome Highly Active Antiretroviral Therapy |
description |
The introduction of highly active antiretroviral therapy (HAART) has significantly improved the clinical outcome of HIV disease, with increased survival rates. However, the introduction of HAART has generated a contrast in the cardiac manifestations of AIDS. In developed countries, we observed an approximate 30% reduction in the prevalence of HIV-associated cardiomyopathy, possibly related to a reduction of opportunistic infections and myocarditis. In developing countries, however, where the availability of HAART is limited and the pathogenic impact of nutritional factors is significant, we observed an increase of approximately 32% in the prevalence of HIV-associated cardiomyopathy and a related high mortality rate from congestive heart failure. Also, some HAART regimens in developed countries, especially those including protease inhibitors, have been shown to cause, in a high proportion of HIV-infected patients, a iatrogenic metabolic syndrome (HIV-lipodystrophy syndrome).This is associated with an increased risk of atherosclerosis-related cardiovascular events even in young HIV-infected people. A better understanding of the molecular mechanisms responsible for this syndrome will lead to the discovery of new drugs that will reduce cardiovascular risk in HIV-infected patients receiving HAART. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302009000500031 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302009000500031 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0104-42302009000500031 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.55 n.5 2009 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
institution |
AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
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1754212828817915904 |