Maternal-fetal alloimmunization: perinatal outcomes in a reference hospital in Northeastern Brazil

Detalhes bibliográficos
Autor(a) principal: Duete,Úlima Rates
Data de Publicação: 2022
Outros Autores: Brunetta,Denise Menezes, Araujo Júnior,Edward, Tonni,Gabriele, Carvalho,Francisco Herlânio Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Associação Médica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302022000500670
Resumo: SUMMARY OBJECTIVE: To assess the prevalence of maternal alloantibodies in pregnant women at a maternity hospital in northeastern Brazil and describe their perinatal outcomes. METHODS: A retrospective cohort study reviewed maternal and newborn medical records between January 2017 and October 2018 to assess for the presence of maternal alloantibodies. RESULTS: The following maternal alloantibodies were found in the 41 cases surveyed: anti-D, 28 cases (45%); anti-C, 7 cases (11%); anti-c, 1 case (1.6%); anti-E, 4 cases (6.4%); anti-Cw, 1 case (1.6%); anti-K, 2 cases (3.2%); anti-Jka, 1 case (1.6%); anti-M, 3 cases (4.8%); anti-Fya, 2 cases (3.2%); anti-Fyb, 1 case (1.6%); anti-Lea, 5 cases (8%); anti-Leb, 3 cases (4.8%); and anti-Dia, 4 cases (6.4%). Anti-D antibodies were the most frequent cause of erythrocyte alloimmunization (80%). Fetal anemia was observed in four pregnancies based on the peak systolic velocity of the middle cerebral artery. In one case, the mother showed anti-M, and anti-Lea alloimmunization, but the direct antiglobulin test results for the newborn were negative, and no unfavorable neonatal outcomes were observed. In one case of a mother with anti-C and anti-D alloimmunization, the neonate showed anti-D antibodies only in the serological panel and required phototherapy. Neonates with plasma antibodies and jaundice requiring phototherapy only had a serological panel with anti-D, anti-C, anti-c, and anti-E antibodies. Intervention was required for 2.5% of pregnant women with positive antibody screens and 81% of newborns with positive direct antiglobulin test results. CONCLUSION: Despite being a rare condition, maternal alloimmunization by irregular antibodies can result in high perinatal morbidity and mortality.
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spelling Maternal-fetal alloimmunization: perinatal outcomes in a reference hospital in Northeastern BrazilFetal erythroblastosisAntibodiesFetal outcomesSUMMARY OBJECTIVE: To assess the prevalence of maternal alloantibodies in pregnant women at a maternity hospital in northeastern Brazil and describe their perinatal outcomes. METHODS: A retrospective cohort study reviewed maternal and newborn medical records between January 2017 and October 2018 to assess for the presence of maternal alloantibodies. RESULTS: The following maternal alloantibodies were found in the 41 cases surveyed: anti-D, 28 cases (45%); anti-C, 7 cases (11%); anti-c, 1 case (1.6%); anti-E, 4 cases (6.4%); anti-Cw, 1 case (1.6%); anti-K, 2 cases (3.2%); anti-Jka, 1 case (1.6%); anti-M, 3 cases (4.8%); anti-Fya, 2 cases (3.2%); anti-Fyb, 1 case (1.6%); anti-Lea, 5 cases (8%); anti-Leb, 3 cases (4.8%); and anti-Dia, 4 cases (6.4%). Anti-D antibodies were the most frequent cause of erythrocyte alloimmunization (80%). Fetal anemia was observed in four pregnancies based on the peak systolic velocity of the middle cerebral artery. In one case, the mother showed anti-M, and anti-Lea alloimmunization, but the direct antiglobulin test results for the newborn were negative, and no unfavorable neonatal outcomes were observed. In one case of a mother with anti-C and anti-D alloimmunization, the neonate showed anti-D antibodies only in the serological panel and required phototherapy. Neonates with plasma antibodies and jaundice requiring phototherapy only had a serological panel with anti-D, anti-C, anti-c, and anti-E antibodies. Intervention was required for 2.5% of pregnant women with positive antibody screens and 81% of newborns with positive direct antiglobulin test results. CONCLUSION: Despite being a rare condition, maternal alloimmunization by irregular antibodies can result in high perinatal morbidity and mortality.Associação Médica Brasileira2022-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302022000500670Revista da Associação Médica Brasileira v.68 n.5 2022reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.20220047info:eu-repo/semantics/openAccessDuete,Úlima RatesBrunetta,Denise MenezesAraujo Júnior,EdwardTonni,GabrieleCarvalho,Francisco Herlânio Costaeng2022-09-13T00:00:00Zoai:scielo:S0104-42302022000500670Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2022-09-13T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false
dc.title.none.fl_str_mv Maternal-fetal alloimmunization: perinatal outcomes in a reference hospital in Northeastern Brazil
title Maternal-fetal alloimmunization: perinatal outcomes in a reference hospital in Northeastern Brazil
spellingShingle Maternal-fetal alloimmunization: perinatal outcomes in a reference hospital in Northeastern Brazil
Duete,Úlima Rates
Fetal erythroblastosis
Antibodies
Fetal outcomes
title_short Maternal-fetal alloimmunization: perinatal outcomes in a reference hospital in Northeastern Brazil
title_full Maternal-fetal alloimmunization: perinatal outcomes in a reference hospital in Northeastern Brazil
title_fullStr Maternal-fetal alloimmunization: perinatal outcomes in a reference hospital in Northeastern Brazil
title_full_unstemmed Maternal-fetal alloimmunization: perinatal outcomes in a reference hospital in Northeastern Brazil
title_sort Maternal-fetal alloimmunization: perinatal outcomes in a reference hospital in Northeastern Brazil
author Duete,Úlima Rates
author_facet Duete,Úlima Rates
Brunetta,Denise Menezes
Araujo Júnior,Edward
Tonni,Gabriele
Carvalho,Francisco Herlânio Costa
author_role author
author2 Brunetta,Denise Menezes
Araujo Júnior,Edward
Tonni,Gabriele
Carvalho,Francisco Herlânio Costa
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Duete,Úlima Rates
Brunetta,Denise Menezes
Araujo Júnior,Edward
Tonni,Gabriele
Carvalho,Francisco Herlânio Costa
dc.subject.por.fl_str_mv Fetal erythroblastosis
Antibodies
Fetal outcomes
topic Fetal erythroblastosis
Antibodies
Fetal outcomes
description SUMMARY OBJECTIVE: To assess the prevalence of maternal alloantibodies in pregnant women at a maternity hospital in northeastern Brazil and describe their perinatal outcomes. METHODS: A retrospective cohort study reviewed maternal and newborn medical records between January 2017 and October 2018 to assess for the presence of maternal alloantibodies. RESULTS: The following maternal alloantibodies were found in the 41 cases surveyed: anti-D, 28 cases (45%); anti-C, 7 cases (11%); anti-c, 1 case (1.6%); anti-E, 4 cases (6.4%); anti-Cw, 1 case (1.6%); anti-K, 2 cases (3.2%); anti-Jka, 1 case (1.6%); anti-M, 3 cases (4.8%); anti-Fya, 2 cases (3.2%); anti-Fyb, 1 case (1.6%); anti-Lea, 5 cases (8%); anti-Leb, 3 cases (4.8%); and anti-Dia, 4 cases (6.4%). Anti-D antibodies were the most frequent cause of erythrocyte alloimmunization (80%). Fetal anemia was observed in four pregnancies based on the peak systolic velocity of the middle cerebral artery. In one case, the mother showed anti-M, and anti-Lea alloimmunization, but the direct antiglobulin test results for the newborn were negative, and no unfavorable neonatal outcomes were observed. In one case of a mother with anti-C and anti-D alloimmunization, the neonate showed anti-D antibodies only in the serological panel and required phototherapy. Neonates with plasma antibodies and jaundice requiring phototherapy only had a serological panel with anti-D, anti-C, anti-c, and anti-E antibodies. Intervention was required for 2.5% of pregnant women with positive antibody screens and 81% of newborns with positive direct antiglobulin test results. CONCLUSION: Despite being a rare condition, maternal alloimmunization by irregular antibodies can result in high perinatal morbidity and mortality.
publishDate 2022
dc.date.none.fl_str_mv 2022-05-01
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dc.relation.none.fl_str_mv 10.1590/1806-9282.20220047
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dc.publisher.none.fl_str_mv Associação Médica Brasileira
publisher.none.fl_str_mv Associação Médica Brasileira
dc.source.none.fl_str_mv Revista da Associação Médica Brasileira v.68 n.5 2022
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