Association between antipsychotics and cardiovascular adverse events: A systematic review

Detalhes bibliográficos
Autor(a) principal: Silva,Ana Amancio Santos Da
Data de Publicação: 2017
Outros Autores: Ribeiro,Marina Viegas Moura Rezende, Sousa-Rodrigues,Célio Fernando de, Barbosa,Fabiano Timbó
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Associação Médica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000300261
Resumo: Summary Objective: Determine whether there is an association between the risk of cardiovascular adverse events and the use of antipsychotic agents. Method: Analysis of original articles retrieved from the following databases: LILACS, PubMed, Cochrane Controlled Trials Clinical Data Bank (CENTRAL) and PsycINFO, without language restriction, dated until November 2015. After screening of 2,812 studies, three cohort original articles were selected for quality analysis. Results: 403,083 patients with schizophrenia and 119,015 participants in the control group data were analyzed. The occurrence of cardiovascular events observed in the articles was: 63.5% (article 1), 13.1% (article 2) and 24.95% (article 3) in the group of treated schizophrenic patients, and 46.2%, 86.9% and 24.9%, respectively, in the control groups. Conclusion: Clinical heterogeneity among the studies led to a provisional response and made it impossible to perform the meta-analysis, although the articles demonstrate an association between cardiovascular adverse events and the use of antipsychotics. More quality clinical trials are needed to support this evidence.
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spelling Association between antipsychotics and cardiovascular adverse events: A systematic reviewantipsychoticscardiovascular diseasesschizophreniaSummary Objective: Determine whether there is an association between the risk of cardiovascular adverse events and the use of antipsychotic agents. Method: Analysis of original articles retrieved from the following databases: LILACS, PubMed, Cochrane Controlled Trials Clinical Data Bank (CENTRAL) and PsycINFO, without language restriction, dated until November 2015. After screening of 2,812 studies, three cohort original articles were selected for quality analysis. Results: 403,083 patients with schizophrenia and 119,015 participants in the control group data were analyzed. The occurrence of cardiovascular events observed in the articles was: 63.5% (article 1), 13.1% (article 2) and 24.95% (article 3) in the group of treated schizophrenic patients, and 46.2%, 86.9% and 24.9%, respectively, in the control groups. Conclusion: Clinical heterogeneity among the studies led to a provisional response and made it impossible to perform the meta-analysis, although the articles demonstrate an association between cardiovascular adverse events and the use of antipsychotics. More quality clinical trials are needed to support this evidence.Associação Médica Brasileira2017-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000300261Revista da Associação Médica Brasileira v.63 n.3 2017reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.63.03.261info:eu-repo/semantics/openAccessSilva,Ana Amancio Santos DaRibeiro,Marina Viegas Moura RezendeSousa-Rodrigues,Célio Fernando deBarbosa,Fabiano Timbóeng2017-04-26T00:00:00Zoai:scielo:S0104-42302017000300261Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2017-04-26T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false
dc.title.none.fl_str_mv Association between antipsychotics and cardiovascular adverse events: A systematic review
title Association between antipsychotics and cardiovascular adverse events: A systematic review
spellingShingle Association between antipsychotics and cardiovascular adverse events: A systematic review
Silva,Ana Amancio Santos Da
antipsychotics
cardiovascular diseases
schizophrenia
title_short Association between antipsychotics and cardiovascular adverse events: A systematic review
title_full Association between antipsychotics and cardiovascular adverse events: A systematic review
title_fullStr Association between antipsychotics and cardiovascular adverse events: A systematic review
title_full_unstemmed Association between antipsychotics and cardiovascular adverse events: A systematic review
title_sort Association between antipsychotics and cardiovascular adverse events: A systematic review
author Silva,Ana Amancio Santos Da
author_facet Silva,Ana Amancio Santos Da
Ribeiro,Marina Viegas Moura Rezende
Sousa-Rodrigues,Célio Fernando de
Barbosa,Fabiano Timbó
author_role author
author2 Ribeiro,Marina Viegas Moura Rezende
Sousa-Rodrigues,Célio Fernando de
Barbosa,Fabiano Timbó
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva,Ana Amancio Santos Da
Ribeiro,Marina Viegas Moura Rezende
Sousa-Rodrigues,Célio Fernando de
Barbosa,Fabiano Timbó
dc.subject.por.fl_str_mv antipsychotics
cardiovascular diseases
schizophrenia
topic antipsychotics
cardiovascular diseases
schizophrenia
description Summary Objective: Determine whether there is an association between the risk of cardiovascular adverse events and the use of antipsychotic agents. Method: Analysis of original articles retrieved from the following databases: LILACS, PubMed, Cochrane Controlled Trials Clinical Data Bank (CENTRAL) and PsycINFO, without language restriction, dated until November 2015. After screening of 2,812 studies, three cohort original articles were selected for quality analysis. Results: 403,083 patients with schizophrenia and 119,015 participants in the control group data were analyzed. The occurrence of cardiovascular events observed in the articles was: 63.5% (article 1), 13.1% (article 2) and 24.95% (article 3) in the group of treated schizophrenic patients, and 46.2%, 86.9% and 24.9%, respectively, in the control groups. Conclusion: Clinical heterogeneity among the studies led to a provisional response and made it impossible to perform the meta-analysis, although the articles demonstrate an association between cardiovascular adverse events and the use of antipsychotics. More quality clinical trials are needed to support this evidence.
publishDate 2017
dc.date.none.fl_str_mv 2017-03-01
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/1806-9282.63.03.261
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dc.publisher.none.fl_str_mv Associação Médica Brasileira
publisher.none.fl_str_mv Associação Médica Brasileira
dc.source.none.fl_str_mv Revista da Associação Médica Brasileira v.63 n.3 2017
reponame:Revista da Associação Médica Brasileira (Online)
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