Prevalence of fungemia in a tertiary hospital: Analysis of the last decade

Detalhes bibliográficos
Autor(a) principal: Castro,Luísa Lima
Data de Publicação: 2016
Outros Autores: Schütze,Manuel, Bücker,Daniel Henrique, Vasconcellos,Leonardo de Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Associação Médica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016000400315
Resumo: Summary Introduction: The prevalence of nosocomial fungemia has increased worldwide, and mortality caused by this disease is high. Objective: To assess progress in the last decade, and the prevalence and profile of fungal agents isolated in blood cultures performed in a tertiary university hospital. Method: All the results of blood cultures processed at Hospital das Clínicas, Universidade Federal de Minas Gerais (HC-UFMG), in the time intervals 2001-2003 and 2011-2013 were analyzed retrospectively. For each three-year period, the number of collected blood cultures, the overall positivity rate and the percentage of fungemia were recorded. In addition, all identified fungal species were cataloged. All blood samples were incubated in the BacT/ALERT® (bioMérieux) automation system. Results: In 2001-2003, 34,822 samples were evaluated, with 5,510 (15.8%) positive results. In 2011-2013, the number of blood cultures processed increased to 55,052 samples, with 4,873 (8.9%) positive results. There was an increase in the number of positive cultures for fungi in the analyzed period (2001-2003: 4.16%; 2011-2013: 5.95%; p<0.001). Among the agents, candidemias were predominant, especially those caused by non-albicans Candida species (2001-2003: 57.64%; 2011-2013: 65.17%; p<0.05). There was also an increase in fungemia caused by other genera (2001-2003: 2.62%; 2011-2013: 4.48%; p<0.01). Conclusion: There was an increase in the prevalence of fungemia in the last decade at HC-UFMG. Although candidemias have been responsible for most of the cases, there has been an increase in fungemias caused by other species.
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spelling Prevalence of fungemia in a tertiary hospital: Analysis of the last decadeCandidanon-albicans Candidafungemiatertiary health careprevalenceSummary Introduction: The prevalence of nosocomial fungemia has increased worldwide, and mortality caused by this disease is high. Objective: To assess progress in the last decade, and the prevalence and profile of fungal agents isolated in blood cultures performed in a tertiary university hospital. Method: All the results of blood cultures processed at Hospital das Clínicas, Universidade Federal de Minas Gerais (HC-UFMG), in the time intervals 2001-2003 and 2011-2013 were analyzed retrospectively. For each three-year period, the number of collected blood cultures, the overall positivity rate and the percentage of fungemia were recorded. In addition, all identified fungal species were cataloged. All blood samples were incubated in the BacT/ALERT® (bioMérieux) automation system. Results: In 2001-2003, 34,822 samples were evaluated, with 5,510 (15.8%) positive results. In 2011-2013, the number of blood cultures processed increased to 55,052 samples, with 4,873 (8.9%) positive results. There was an increase in the number of positive cultures for fungi in the analyzed period (2001-2003: 4.16%; 2011-2013: 5.95%; p<0.001). Among the agents, candidemias were predominant, especially those caused by non-albicans Candida species (2001-2003: 57.64%; 2011-2013: 65.17%; p<0.05). There was also an increase in fungemia caused by other genera (2001-2003: 2.62%; 2011-2013: 4.48%; p<0.01). Conclusion: There was an increase in the prevalence of fungemia in the last decade at HC-UFMG. Although candidemias have been responsible for most of the cases, there has been an increase in fungemias caused by other species.Associação Médica Brasileira2016-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016000400315Revista da Associação Médica Brasileira v.62 n.4 2016reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.62.04.315info:eu-repo/semantics/openAccessCastro,Luísa LimaSchütze,ManuelBücker,Daniel HenriqueVasconcellos,Leonardo de Souzaeng2016-07-19T00:00:00Zoai:scielo:S0104-42302016000400315Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2016-07-19T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false
dc.title.none.fl_str_mv Prevalence of fungemia in a tertiary hospital: Analysis of the last decade
title Prevalence of fungemia in a tertiary hospital: Analysis of the last decade
spellingShingle Prevalence of fungemia in a tertiary hospital: Analysis of the last decade
Castro,Luísa Lima
Candida
non-albicans Candida
fungemia
tertiary health care
prevalence
title_short Prevalence of fungemia in a tertiary hospital: Analysis of the last decade
title_full Prevalence of fungemia in a tertiary hospital: Analysis of the last decade
title_fullStr Prevalence of fungemia in a tertiary hospital: Analysis of the last decade
title_full_unstemmed Prevalence of fungemia in a tertiary hospital: Analysis of the last decade
title_sort Prevalence of fungemia in a tertiary hospital: Analysis of the last decade
author Castro,Luísa Lima
author_facet Castro,Luísa Lima
Schütze,Manuel
Bücker,Daniel Henrique
Vasconcellos,Leonardo de Souza
author_role author
author2 Schütze,Manuel
Bücker,Daniel Henrique
Vasconcellos,Leonardo de Souza
author2_role author
author
author
dc.contributor.author.fl_str_mv Castro,Luísa Lima
Schütze,Manuel
Bücker,Daniel Henrique
Vasconcellos,Leonardo de Souza
dc.subject.por.fl_str_mv Candida
non-albicans Candida
fungemia
tertiary health care
prevalence
topic Candida
non-albicans Candida
fungemia
tertiary health care
prevalence
description Summary Introduction: The prevalence of nosocomial fungemia has increased worldwide, and mortality caused by this disease is high. Objective: To assess progress in the last decade, and the prevalence and profile of fungal agents isolated in blood cultures performed in a tertiary university hospital. Method: All the results of blood cultures processed at Hospital das Clínicas, Universidade Federal de Minas Gerais (HC-UFMG), in the time intervals 2001-2003 and 2011-2013 were analyzed retrospectively. For each three-year period, the number of collected blood cultures, the overall positivity rate and the percentage of fungemia were recorded. In addition, all identified fungal species were cataloged. All blood samples were incubated in the BacT/ALERT® (bioMérieux) automation system. Results: In 2001-2003, 34,822 samples were evaluated, with 5,510 (15.8%) positive results. In 2011-2013, the number of blood cultures processed increased to 55,052 samples, with 4,873 (8.9%) positive results. There was an increase in the number of positive cultures for fungi in the analyzed period (2001-2003: 4.16%; 2011-2013: 5.95%; p<0.001). Among the agents, candidemias were predominant, especially those caused by non-albicans Candida species (2001-2003: 57.64%; 2011-2013: 65.17%; p<0.05). There was also an increase in fungemia caused by other genera (2001-2003: 2.62%; 2011-2013: 4.48%; p<0.01). Conclusion: There was an increase in the prevalence of fungemia in the last decade at HC-UFMG. Although candidemias have been responsible for most of the cases, there has been an increase in fungemias caused by other species.
publishDate 2016
dc.date.none.fl_str_mv 2016-07-01
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