Laboratory findings in SARS-CoV-2 infections: State of the art

Detalhes bibliográficos
Autor(a) principal: Pereira,Miguel Augusto Martins
Data de Publicação: 2020
Outros Autores: Barros,Isabella Carolina de Almeida, Jacob,Ana Luiza Veríssimo, Assis,Mayara Lopes de, Kanaan,Salim, Kang,Hye Chung
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Associação Médica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020000801152
Resumo: SUMMARY OBJECTIVE The scientific community is constantly assessing the clinical and laboratory manifestations of COVID-19 in the organism. In view of the fragmentation of the large amount of information, knowledge gaps in relation to laboratory markers, and scarcity of papers in Portuguese, we propose a Literature review on laboratory changes observed in patients infected with SARS-CoV-2. METHODS Analysis of articles published between December 2019 and May 2020 on the PubMed and SciELO databases. The articles were identified, filtered, and evaluated based on the approach to the subject, language, and impact. Then, the articles were subjected to a thorough reading, in full, by 4 (four) independent researchers. RESULTS Leukopenia and lymphopenia were included in most studies, even in case definitions. Platelet count and platelet-lymphocyte ratio, at peak platelet, were associated with advanced age and longer hospital stay. Eosinopenia showed a sensitivity of 74.7% and specificity of 68.7% and, together with increased CRP, these are one of the future prospects for screening for disease. A high level of procalcitonin may indicate bacterial co-infection, leading to a worse prognosis. COVID-19 manifests itself with increased levels of many inflammatory markers such as IL-1, IL-2, IL-6, IL-7, IL-12, IP10, IFN-γ, MIP1A, MCP1, GSCF, TNF-α, and MCP1/CCL2, as well as LDH, ESR, D-dimer, CK, ALT, and AST. CONCLUSION There is a need for further studies on the new SARS-CoV-2. So far, there is no consensus regarding laboratory findings and their usefulness, whether as a prognostic marker, mortality, or disease severity.
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spelling Laboratory findings in SARS-CoV-2 infections: State of the artCoronavirus InfectionsBetacoronavirusBlood Cell CountLeukocyte CountSUMMARY OBJECTIVE The scientific community is constantly assessing the clinical and laboratory manifestations of COVID-19 in the organism. In view of the fragmentation of the large amount of information, knowledge gaps in relation to laboratory markers, and scarcity of papers in Portuguese, we propose a Literature review on laboratory changes observed in patients infected with SARS-CoV-2. METHODS Analysis of articles published between December 2019 and May 2020 on the PubMed and SciELO databases. The articles were identified, filtered, and evaluated based on the approach to the subject, language, and impact. Then, the articles were subjected to a thorough reading, in full, by 4 (four) independent researchers. RESULTS Leukopenia and lymphopenia were included in most studies, even in case definitions. Platelet count and platelet-lymphocyte ratio, at peak platelet, were associated with advanced age and longer hospital stay. Eosinopenia showed a sensitivity of 74.7% and specificity of 68.7% and, together with increased CRP, these are one of the future prospects for screening for disease. A high level of procalcitonin may indicate bacterial co-infection, leading to a worse prognosis. COVID-19 manifests itself with increased levels of many inflammatory markers such as IL-1, IL-2, IL-6, IL-7, IL-12, IP10, IFN-γ, MIP1A, MCP1, GSCF, TNF-α, and MCP1/CCL2, as well as LDH, ESR, D-dimer, CK, ALT, and AST. CONCLUSION There is a need for further studies on the new SARS-CoV-2. So far, there is no consensus regarding laboratory findings and their usefulness, whether as a prognostic marker, mortality, or disease severity.Associação Médica Brasileira2020-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020000801152Revista da Associação Médica Brasileira v.66 n.8 2020reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.66.8.1152info:eu-repo/semantics/openAccessPereira,Miguel Augusto MartinsBarros,Isabella Carolina de AlmeidaJacob,Ana Luiza VeríssimoAssis,Mayara Lopes deKanaan,SalimKang,Hye Chungeng2020-09-09T00:00:00Zoai:scielo:S0104-42302020000801152Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2020-09-09T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false
dc.title.none.fl_str_mv Laboratory findings in SARS-CoV-2 infections: State of the art
title Laboratory findings in SARS-CoV-2 infections: State of the art
spellingShingle Laboratory findings in SARS-CoV-2 infections: State of the art
Pereira,Miguel Augusto Martins
Coronavirus Infections
Betacoronavirus
Blood Cell Count
Leukocyte Count
title_short Laboratory findings in SARS-CoV-2 infections: State of the art
title_full Laboratory findings in SARS-CoV-2 infections: State of the art
title_fullStr Laboratory findings in SARS-CoV-2 infections: State of the art
title_full_unstemmed Laboratory findings in SARS-CoV-2 infections: State of the art
title_sort Laboratory findings in SARS-CoV-2 infections: State of the art
author Pereira,Miguel Augusto Martins
author_facet Pereira,Miguel Augusto Martins
Barros,Isabella Carolina de Almeida
Jacob,Ana Luiza Veríssimo
Assis,Mayara Lopes de
Kanaan,Salim
Kang,Hye Chung
author_role author
author2 Barros,Isabella Carolina de Almeida
Jacob,Ana Luiza Veríssimo
Assis,Mayara Lopes de
Kanaan,Salim
Kang,Hye Chung
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira,Miguel Augusto Martins
Barros,Isabella Carolina de Almeida
Jacob,Ana Luiza Veríssimo
Assis,Mayara Lopes de
Kanaan,Salim
Kang,Hye Chung
dc.subject.por.fl_str_mv Coronavirus Infections
Betacoronavirus
Blood Cell Count
Leukocyte Count
topic Coronavirus Infections
Betacoronavirus
Blood Cell Count
Leukocyte Count
description SUMMARY OBJECTIVE The scientific community is constantly assessing the clinical and laboratory manifestations of COVID-19 in the organism. In view of the fragmentation of the large amount of information, knowledge gaps in relation to laboratory markers, and scarcity of papers in Portuguese, we propose a Literature review on laboratory changes observed in patients infected with SARS-CoV-2. METHODS Analysis of articles published between December 2019 and May 2020 on the PubMed and SciELO databases. The articles were identified, filtered, and evaluated based on the approach to the subject, language, and impact. Then, the articles were subjected to a thorough reading, in full, by 4 (four) independent researchers. RESULTS Leukopenia and lymphopenia were included in most studies, even in case definitions. Platelet count and platelet-lymphocyte ratio, at peak platelet, were associated with advanced age and longer hospital stay. Eosinopenia showed a sensitivity of 74.7% and specificity of 68.7% and, together with increased CRP, these are one of the future prospects for screening for disease. A high level of procalcitonin may indicate bacterial co-infection, leading to a worse prognosis. COVID-19 manifests itself with increased levels of many inflammatory markers such as IL-1, IL-2, IL-6, IL-7, IL-12, IP10, IFN-γ, MIP1A, MCP1, GSCF, TNF-α, and MCP1/CCL2, as well as LDH, ESR, D-dimer, CK, ALT, and AST. CONCLUSION There is a need for further studies on the new SARS-CoV-2. So far, there is no consensus regarding laboratory findings and their usefulness, whether as a prognostic marker, mortality, or disease severity.
publishDate 2020
dc.date.none.fl_str_mv 2020-08-01
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dc.relation.none.fl_str_mv 10.1590/1806-9282.66.8.1152
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dc.publisher.none.fl_str_mv Associação Médica Brasileira
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dc.source.none.fl_str_mv Revista da Associação Médica Brasileira v.66 n.8 2020
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