Prevalence of low bone mineral density in adolescents and adults with cystic fibrosis

Detalhes bibliográficos
Autor(a) principal: Vanacor,Roberta
Data de Publicação: 2014
Outros Autores: Raimundo,Fabiana V., Marcondes,Natália A., Corte,Bruno P., Ascoli,Aline M., Azambuja,Aline Z. de, Scopel,Luciano, Santos,Patrícia V. dos, Dalcin,Paulo T. R., Faulhaber,Gustavo A. M., Furlanetto,Tânia W.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Associação Médica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302014000100053
Resumo: Objective The aim of this cross-sectional study was to evaluate the prevalence of low bone mass density in cystic fibrosis patients as well as to evaluate the factors associated with bone mass in such patients. Methods Bone mass density was measured by dual-photon X-ray absorptiometry of lumbar spine (L1-L4), in patients ≤19 years old, or lumbar spine and femur (total and neck) in patients ≥20 years old. Evaluations of nutritional status, biochemical parameters, and lung function were performed. Medication data were obtained from medical records. Results Fifty-eight patients were included in the study (25 males/ 33 females), mean age 23.9 years (16-53years). The prevalence of bone mass below the expected range for age at any site was 20.7%. None of the subjects had history of fracture. Lumbar spine Z-score in cystic fibrosis patients correlated positively with body mass index (r= 0.3, p=0.001), and forced expiratory volume in the first second (% predicted) (r=0.415, p=0.022). Mean lumbar spine Z-score was higher in women (p=0.001), in patients with no pancreatic insufficiency (p=0.032), and in patients with no hospitalization in the last 3 months (p=0.02). After multivariate analysis, body mass index (p= 0.001) and sex (p=0.001) were independently associated with Z-score in lumbar spine. Conclusion Low bone mass is a frequent problem in patients with CF, being independently associated with body mass index, and male sex.
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spelling Prevalence of low bone mineral density in adolescents and adults with cystic fibrosiscystic fibrosisbonebone densitybone lossbone diseasesmetabolicrisk factors Objective The aim of this cross-sectional study was to evaluate the prevalence of low bone mass density in cystic fibrosis patients as well as to evaluate the factors associated with bone mass in such patients. Methods Bone mass density was measured by dual-photon X-ray absorptiometry of lumbar spine (L1-L4), in patients ≤19 years old, or lumbar spine and femur (total and neck) in patients ≥20 years old. Evaluations of nutritional status, biochemical parameters, and lung function were performed. Medication data were obtained from medical records. Results Fifty-eight patients were included in the study (25 males/ 33 females), mean age 23.9 years (16-53years). The prevalence of bone mass below the expected range for age at any site was 20.7%. None of the subjects had history of fracture. Lumbar spine Z-score in cystic fibrosis patients correlated positively with body mass index (r= 0.3, p=0.001), and forced expiratory volume in the first second (% predicted) (r=0.415, p=0.022). Mean lumbar spine Z-score was higher in women (p=0.001), in patients with no pancreatic insufficiency (p=0.032), and in patients with no hospitalization in the last 3 months (p=0.02). After multivariate analysis, body mass index (p= 0.001) and sex (p=0.001) were independently associated with Z-score in lumbar spine. Conclusion Low bone mass is a frequent problem in patients with CF, being independently associated with body mass index, and male sex. Associação Médica Brasileira2014-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302014000100053Revista da Associação Médica Brasileira v.60 n.1 2014reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.60.01.012info:eu-repo/semantics/openAccessVanacor,RobertaRaimundo,Fabiana V.Marcondes,Natália A.Corte,Bruno P.Ascoli,Aline M.Azambuja,Aline Z. deScopel,LucianoSantos,Patrícia V. dosDalcin,Paulo T. R.Faulhaber,Gustavo A. M.Furlanetto,Tânia W.eng2015-01-09T00:00:00Zoai:scielo:S0104-42302014000100053Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2015-01-09T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false
dc.title.none.fl_str_mv Prevalence of low bone mineral density in adolescents and adults with cystic fibrosis
title Prevalence of low bone mineral density in adolescents and adults with cystic fibrosis
spellingShingle Prevalence of low bone mineral density in adolescents and adults with cystic fibrosis
Vanacor,Roberta
cystic fibrosis
bone
bone density
bone loss
bone diseases
metabolic
risk factors
title_short Prevalence of low bone mineral density in adolescents and adults with cystic fibrosis
title_full Prevalence of low bone mineral density in adolescents and adults with cystic fibrosis
title_fullStr Prevalence of low bone mineral density in adolescents and adults with cystic fibrosis
title_full_unstemmed Prevalence of low bone mineral density in adolescents and adults with cystic fibrosis
title_sort Prevalence of low bone mineral density in adolescents and adults with cystic fibrosis
author Vanacor,Roberta
author_facet Vanacor,Roberta
Raimundo,Fabiana V.
Marcondes,Natália A.
Corte,Bruno P.
Ascoli,Aline M.
Azambuja,Aline Z. de
Scopel,Luciano
Santos,Patrícia V. dos
Dalcin,Paulo T. R.
Faulhaber,Gustavo A. M.
Furlanetto,Tânia W.
author_role author
author2 Raimundo,Fabiana V.
Marcondes,Natália A.
Corte,Bruno P.
Ascoli,Aline M.
Azambuja,Aline Z. de
Scopel,Luciano
Santos,Patrícia V. dos
Dalcin,Paulo T. R.
Faulhaber,Gustavo A. M.
Furlanetto,Tânia W.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vanacor,Roberta
Raimundo,Fabiana V.
Marcondes,Natália A.
Corte,Bruno P.
Ascoli,Aline M.
Azambuja,Aline Z. de
Scopel,Luciano
Santos,Patrícia V. dos
Dalcin,Paulo T. R.
Faulhaber,Gustavo A. M.
Furlanetto,Tânia W.
dc.subject.por.fl_str_mv cystic fibrosis
bone
bone density
bone loss
bone diseases
metabolic
risk factors
topic cystic fibrosis
bone
bone density
bone loss
bone diseases
metabolic
risk factors
description Objective The aim of this cross-sectional study was to evaluate the prevalence of low bone mass density in cystic fibrosis patients as well as to evaluate the factors associated with bone mass in such patients. Methods Bone mass density was measured by dual-photon X-ray absorptiometry of lumbar spine (L1-L4), in patients ≤19 years old, or lumbar spine and femur (total and neck) in patients ≥20 years old. Evaluations of nutritional status, biochemical parameters, and lung function were performed. Medication data were obtained from medical records. Results Fifty-eight patients were included in the study (25 males/ 33 females), mean age 23.9 years (16-53years). The prevalence of bone mass below the expected range for age at any site was 20.7%. None of the subjects had history of fracture. Lumbar spine Z-score in cystic fibrosis patients correlated positively with body mass index (r= 0.3, p=0.001), and forced expiratory volume in the first second (% predicted) (r=0.415, p=0.022). Mean lumbar spine Z-score was higher in women (p=0.001), in patients with no pancreatic insufficiency (p=0.032), and in patients with no hospitalization in the last 3 months (p=0.02). After multivariate analysis, body mass index (p= 0.001) and sex (p=0.001) were independently associated with Z-score in lumbar spine. Conclusion Low bone mass is a frequent problem in patients with CF, being independently associated with body mass index, and male sex.
publishDate 2014
dc.date.none.fl_str_mv 2014-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/1806-9282.60.01.012
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dc.publisher.none.fl_str_mv Associação Médica Brasileira
publisher.none.fl_str_mv Associação Médica Brasileira
dc.source.none.fl_str_mv Revista da Associação Médica Brasileira v.60 n.1 2014
reponame:Revista da Associação Médica Brasileira (Online)
instname:Associação Médica Brasileira (AMB)
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instname_str Associação Médica Brasileira (AMB)
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reponame_str Revista da Associação Médica Brasileira (Online)
collection Revista da Associação Médica Brasileira (Online)
repository.name.fl_str_mv Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)
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