Osteoporosis and autophagy: What is the relationship?

Detalhes bibliográficos
Autor(a) principal: Florencio-Silva,Rinaldo
Data de Publicação: 2017
Outros Autores: Sasso,Gisela Rodrigues da Silva, Simões,Manuel de Jesus, Simões,Ricardo Santos, Baracat,Maria Cândida Pinheiro, Sasso-Cerri,Estela, Cerri,Paulo Sérgio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Associação Médica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000200173
Resumo: Summary Autophagy is a survival pathway wherein non-functional proteins and organelles are degraded in lysosomes for recycling and energy production. Therefore, autophagy is fundamental for the maintenance of cell viability, acting as a quality control process that prevents the accumulation of unnecessary structures and oxidative stress. Increasing evidence has shown that autophagy dysfunction is related to several pathologies including neurodegenerative diseases and cancer. Moreover, recent studies have shown that autophagy plays an important role for the maintenance of bone homeostasis. For instance, in vitro and animal and human studies indicate that autophagy dysfunction in bone cells is associated with the onset of bone diseases such as osteoporosis. This review had the purpose of discussing the issue to confirm whether a relationship between autophagy dysfunction and osteoporosis exits.
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spelling Osteoporosis and autophagy: What is the relationship?autophagybone tissueosteoblastosteocyteosteoclastosteoporosisSummary Autophagy is a survival pathway wherein non-functional proteins and organelles are degraded in lysosomes for recycling and energy production. Therefore, autophagy is fundamental for the maintenance of cell viability, acting as a quality control process that prevents the accumulation of unnecessary structures and oxidative stress. Increasing evidence has shown that autophagy dysfunction is related to several pathologies including neurodegenerative diseases and cancer. Moreover, recent studies have shown that autophagy plays an important role for the maintenance of bone homeostasis. For instance, in vitro and animal and human studies indicate that autophagy dysfunction in bone cells is associated with the onset of bone diseases such as osteoporosis. This review had the purpose of discussing the issue to confirm whether a relationship between autophagy dysfunction and osteoporosis exits.Associação Médica Brasileira2017-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000200173Revista da Associação Médica Brasileira v.63 n.2 2017reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.63.02.173info:eu-repo/semantics/openAccessFlorencio-Silva,RinaldoSasso,Gisela Rodrigues da SilvaSimões,Manuel de JesusSimões,Ricardo SantosBaracat,Maria Cândida PinheiroSasso-Cerri,EstelaCerri,Paulo Sérgioeng2017-03-20T00:00:00Zoai:scielo:S0104-42302017000200173Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2017-03-20T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false
dc.title.none.fl_str_mv Osteoporosis and autophagy: What is the relationship?
title Osteoporosis and autophagy: What is the relationship?
spellingShingle Osteoporosis and autophagy: What is the relationship?
Florencio-Silva,Rinaldo
autophagy
bone tissue
osteoblast
osteocyte
osteoclast
osteoporosis
title_short Osteoporosis and autophagy: What is the relationship?
title_full Osteoporosis and autophagy: What is the relationship?
title_fullStr Osteoporosis and autophagy: What is the relationship?
title_full_unstemmed Osteoporosis and autophagy: What is the relationship?
title_sort Osteoporosis and autophagy: What is the relationship?
author Florencio-Silva,Rinaldo
author_facet Florencio-Silva,Rinaldo
Sasso,Gisela Rodrigues da Silva
Simões,Manuel de Jesus
Simões,Ricardo Santos
Baracat,Maria Cândida Pinheiro
Sasso-Cerri,Estela
Cerri,Paulo Sérgio
author_role author
author2 Sasso,Gisela Rodrigues da Silva
Simões,Manuel de Jesus
Simões,Ricardo Santos
Baracat,Maria Cândida Pinheiro
Sasso-Cerri,Estela
Cerri,Paulo Sérgio
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Florencio-Silva,Rinaldo
Sasso,Gisela Rodrigues da Silva
Simões,Manuel de Jesus
Simões,Ricardo Santos
Baracat,Maria Cândida Pinheiro
Sasso-Cerri,Estela
Cerri,Paulo Sérgio
dc.subject.por.fl_str_mv autophagy
bone tissue
osteoblast
osteocyte
osteoclast
osteoporosis
topic autophagy
bone tissue
osteoblast
osteocyte
osteoclast
osteoporosis
description Summary Autophagy is a survival pathway wherein non-functional proteins and organelles are degraded in lysosomes for recycling and energy production. Therefore, autophagy is fundamental for the maintenance of cell viability, acting as a quality control process that prevents the accumulation of unnecessary structures and oxidative stress. Increasing evidence has shown that autophagy dysfunction is related to several pathologies including neurodegenerative diseases and cancer. Moreover, recent studies have shown that autophagy plays an important role for the maintenance of bone homeostasis. For instance, in vitro and animal and human studies indicate that autophagy dysfunction in bone cells is associated with the onset of bone diseases such as osteoporosis. This review had the purpose of discussing the issue to confirm whether a relationship between autophagy dysfunction and osteoporosis exits.
publishDate 2017
dc.date.none.fl_str_mv 2017-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000200173
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000200173
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1806-9282.63.02.173
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Médica Brasileira
publisher.none.fl_str_mv Associação Médica Brasileira
dc.source.none.fl_str_mv Revista da Associação Médica Brasileira v.63 n.2 2017
reponame:Revista da Associação Médica Brasileira (Online)
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reponame_str Revista da Associação Médica Brasileira (Online)
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repository.name.fl_str_mv Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)
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