Osteoporosis and autophagy: What is the relationship?
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000200173 |
Resumo: | Summary Autophagy is a survival pathway wherein non-functional proteins and organelles are degraded in lysosomes for recycling and energy production. Therefore, autophagy is fundamental for the maintenance of cell viability, acting as a quality control process that prevents the accumulation of unnecessary structures and oxidative stress. Increasing evidence has shown that autophagy dysfunction is related to several pathologies including neurodegenerative diseases and cancer. Moreover, recent studies have shown that autophagy plays an important role for the maintenance of bone homeostasis. For instance, in vitro and animal and human studies indicate that autophagy dysfunction in bone cells is associated with the onset of bone diseases such as osteoporosis. This review had the purpose of discussing the issue to confirm whether a relationship between autophagy dysfunction and osteoporosis exits. |
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Osteoporosis and autophagy: What is the relationship?autophagybone tissueosteoblastosteocyteosteoclastosteoporosisSummary Autophagy is a survival pathway wherein non-functional proteins and organelles are degraded in lysosomes for recycling and energy production. Therefore, autophagy is fundamental for the maintenance of cell viability, acting as a quality control process that prevents the accumulation of unnecessary structures and oxidative stress. Increasing evidence has shown that autophagy dysfunction is related to several pathologies including neurodegenerative diseases and cancer. Moreover, recent studies have shown that autophagy plays an important role for the maintenance of bone homeostasis. For instance, in vitro and animal and human studies indicate that autophagy dysfunction in bone cells is associated with the onset of bone diseases such as osteoporosis. This review had the purpose of discussing the issue to confirm whether a relationship between autophagy dysfunction and osteoporosis exits.Associação Médica Brasileira2017-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000200173Revista da Associação Médica Brasileira v.63 n.2 2017reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.63.02.173info:eu-repo/semantics/openAccessFlorencio-Silva,RinaldoSasso,Gisela Rodrigues da SilvaSimões,Manuel de JesusSimões,Ricardo SantosBaracat,Maria Cândida PinheiroSasso-Cerri,EstelaCerri,Paulo Sérgioeng2017-03-20T00:00:00Zoai:scielo:S0104-42302017000200173Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2017-03-20T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Osteoporosis and autophagy: What is the relationship? |
title |
Osteoporosis and autophagy: What is the relationship? |
spellingShingle |
Osteoporosis and autophagy: What is the relationship? Florencio-Silva,Rinaldo autophagy bone tissue osteoblast osteocyte osteoclast osteoporosis |
title_short |
Osteoporosis and autophagy: What is the relationship? |
title_full |
Osteoporosis and autophagy: What is the relationship? |
title_fullStr |
Osteoporosis and autophagy: What is the relationship? |
title_full_unstemmed |
Osteoporosis and autophagy: What is the relationship? |
title_sort |
Osteoporosis and autophagy: What is the relationship? |
author |
Florencio-Silva,Rinaldo |
author_facet |
Florencio-Silva,Rinaldo Sasso,Gisela Rodrigues da Silva Simões,Manuel de Jesus Simões,Ricardo Santos Baracat,Maria Cândida Pinheiro Sasso-Cerri,Estela Cerri,Paulo Sérgio |
author_role |
author |
author2 |
Sasso,Gisela Rodrigues da Silva Simões,Manuel de Jesus Simões,Ricardo Santos Baracat,Maria Cândida Pinheiro Sasso-Cerri,Estela Cerri,Paulo Sérgio |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Florencio-Silva,Rinaldo Sasso,Gisela Rodrigues da Silva Simões,Manuel de Jesus Simões,Ricardo Santos Baracat,Maria Cândida Pinheiro Sasso-Cerri,Estela Cerri,Paulo Sérgio |
dc.subject.por.fl_str_mv |
autophagy bone tissue osteoblast osteocyte osteoclast osteoporosis |
topic |
autophagy bone tissue osteoblast osteocyte osteoclast osteoporosis |
description |
Summary Autophagy is a survival pathway wherein non-functional proteins and organelles are degraded in lysosomes for recycling and energy production. Therefore, autophagy is fundamental for the maintenance of cell viability, acting as a quality control process that prevents the accumulation of unnecessary structures and oxidative stress. Increasing evidence has shown that autophagy dysfunction is related to several pathologies including neurodegenerative diseases and cancer. Moreover, recent studies have shown that autophagy plays an important role for the maintenance of bone homeostasis. For instance, in vitro and animal and human studies indicate that autophagy dysfunction in bone cells is associated with the onset of bone diseases such as osteoporosis. This review had the purpose of discussing the issue to confirm whether a relationship between autophagy dysfunction and osteoporosis exits. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000200173 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000200173 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-9282.63.02.173 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.63 n.2 2017 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
institution |
AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
repository.mail.fl_str_mv |
||ramb@amb.org.br |
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1754212832390414336 |