Pregnancy outcomes after chemotherapy for trophoblastic neoplasia
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016000900837 |
Resumo: | SUMMARY Introduction The successful development of chemotherapy enabled a fertilitysparing treatment for patients with trophoblastic neoplasia. After disease remission, the outcome of a subsequent pregnancy becomes a great concern for these women. Objective To analyze existing studies in the literature that describe the reproductive outcomes of patients with trophoblastic neoplasia treated with chemotherapy. Method Systematic review was performed searching for articles on Medline/ Pubmed, Lilacs and Cochrane Library databases, using the terms “gestational trophoblastic disease” and “pregnancy outcome”. Results A total of 18 articles were included. No evidence of decreased fertility after chemotherapy for trophoblastic neoplasia was observed. The abortion rates in patients who conceived within 6 months after chemotherapy was higher compared to those who waited longer. Some studies showed increased rates of stillbirth and repeat hydatidiform moles. Only one work showed increased congenital abnormalities. Conclusion The pregnancies conceived after chemotherapy for trophoblastic neoplasia should be followed with clinical surveillance due to higher rates of some pregnancy complications. However, studies in the literature provide reassuring data about reproductive outcomes of these patients. |
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Pregnancy outcomes after chemotherapy for trophoblastic neoplasiagestational trophoblastic diseasehydatidiform molechoriocarcinomachemotherapypregnancyfertilitySUMMARY Introduction The successful development of chemotherapy enabled a fertilitysparing treatment for patients with trophoblastic neoplasia. After disease remission, the outcome of a subsequent pregnancy becomes a great concern for these women. Objective To analyze existing studies in the literature that describe the reproductive outcomes of patients with trophoblastic neoplasia treated with chemotherapy. Method Systematic review was performed searching for articles on Medline/ Pubmed, Lilacs and Cochrane Library databases, using the terms “gestational trophoblastic disease” and “pregnancy outcome”. Results A total of 18 articles were included. No evidence of decreased fertility after chemotherapy for trophoblastic neoplasia was observed. The abortion rates in patients who conceived within 6 months after chemotherapy was higher compared to those who waited longer. Some studies showed increased rates of stillbirth and repeat hydatidiform moles. Only one work showed increased congenital abnormalities. Conclusion The pregnancies conceived after chemotherapy for trophoblastic neoplasia should be followed with clinical surveillance due to higher rates of some pregnancy complications. However, studies in the literature provide reassuring data about reproductive outcomes of these patients.Associação Médica Brasileira2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016000900837Revista da Associação Médica Brasileira v.62 n.9 2016reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.62.09.837info:eu-repo/semantics/openAccessGARCIA,MILA TREMENTOSALIN,LAWRENCE HSUFUSHIDA,KOJIFRANCISCO,ROSSANA PULCINELI VIEIRAZUGAIB,MARCELOeng2016-12-16T00:00:00Zoai:scielo:S0104-42302016000900837Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2016-12-16T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Pregnancy outcomes after chemotherapy for trophoblastic neoplasia |
title |
Pregnancy outcomes after chemotherapy for trophoblastic neoplasia |
spellingShingle |
Pregnancy outcomes after chemotherapy for trophoblastic neoplasia GARCIA,MILA TREMENTOSA gestational trophoblastic disease hydatidiform mole choriocarcinoma chemotherapy pregnancy fertility |
title_short |
Pregnancy outcomes after chemotherapy for trophoblastic neoplasia |
title_full |
Pregnancy outcomes after chemotherapy for trophoblastic neoplasia |
title_fullStr |
Pregnancy outcomes after chemotherapy for trophoblastic neoplasia |
title_full_unstemmed |
Pregnancy outcomes after chemotherapy for trophoblastic neoplasia |
title_sort |
Pregnancy outcomes after chemotherapy for trophoblastic neoplasia |
author |
GARCIA,MILA TREMENTOSA |
author_facet |
GARCIA,MILA TREMENTOSA LIN,LAWRENCE HSU FUSHIDA,KOJI FRANCISCO,ROSSANA PULCINELI VIEIRA ZUGAIB,MARCELO |
author_role |
author |
author2 |
LIN,LAWRENCE HSU FUSHIDA,KOJI FRANCISCO,ROSSANA PULCINELI VIEIRA ZUGAIB,MARCELO |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
GARCIA,MILA TREMENTOSA LIN,LAWRENCE HSU FUSHIDA,KOJI FRANCISCO,ROSSANA PULCINELI VIEIRA ZUGAIB,MARCELO |
dc.subject.por.fl_str_mv |
gestational trophoblastic disease hydatidiform mole choriocarcinoma chemotherapy pregnancy fertility |
topic |
gestational trophoblastic disease hydatidiform mole choriocarcinoma chemotherapy pregnancy fertility |
description |
SUMMARY Introduction The successful development of chemotherapy enabled a fertilitysparing treatment for patients with trophoblastic neoplasia. After disease remission, the outcome of a subsequent pregnancy becomes a great concern for these women. Objective To analyze existing studies in the literature that describe the reproductive outcomes of patients with trophoblastic neoplasia treated with chemotherapy. Method Systematic review was performed searching for articles on Medline/ Pubmed, Lilacs and Cochrane Library databases, using the terms “gestational trophoblastic disease” and “pregnancy outcome”. Results A total of 18 articles were included. No evidence of decreased fertility after chemotherapy for trophoblastic neoplasia was observed. The abortion rates in patients who conceived within 6 months after chemotherapy was higher compared to those who waited longer. Some studies showed increased rates of stillbirth and repeat hydatidiform moles. Only one work showed increased congenital abnormalities. Conclusion The pregnancies conceived after chemotherapy for trophoblastic neoplasia should be followed with clinical surveillance due to higher rates of some pregnancy complications. However, studies in the literature provide reassuring data about reproductive outcomes of these patients. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016000900837 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016000900837 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-9282.62.09.837 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.62 n.9 2016 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
institution |
AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
repository.mail.fl_str_mv |
||ramb@amb.org.br |
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1754212832321208320 |