Evaluation of the effect of antibiotics used during parenteral nutrition treatment on Candidemia
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302021001101448 |
Resumo: | SUMMARY OBJECTIVE: Parenteral nutrition is an important risk factor for candidemia. In this risk analysis study, the effect of previous antibiotic administration apart from the length of hospital stay, duration of Parenteral nutrition treatment, and Candida score parameters on developing candidemia was evaluated in the non-neutropenic patients receiving Parenteral nutrition treatment. METHODS: In this double center, retrospective, and cross-sectional study, the data of patients who received Parenteral nutrition treatment were collected. Patients with or without candidemia after the initiation of Parenteral nutrition treatment were compared in terms of demographic features, Candida score, length of hospital stay, duration of Parenteral nutrition treatment, and previous use of antibiotics. Then, predictor factors affecting the probability of candidemia during Candida growth time were determined by the Cox regression analysis. RESULTS: A total of 148 patients (59.5% males) were included and 16 (10.81%) of these had candidemia after initiation of parenteral nutrition treatment. The median (min–max) duration of parenteral nutrition treatment was 11 (4–72) days and the Candida growth time was 13 (7–29) days. Statistically significant differences were found between patients with or without candidemia groups in terms of length of hospital stay (p<0.001), duration of parenteral nutrition treatment (p<0.001), and Candida score (p<0.001). To determine the effect of these variables and antibiotics on candidemia, length of hospital stay [Hazard Ratio 1.030; p=0.021] and piperacillin–tazobactam (Hazard Ratio 5.626; p=0.030) were found significant and independent risk factors on the development of candidemia. CONCLUSION: There are some well-known risk factors including length of hospital stay, duration of Parenteral nutrition treatment, and Candida score; the potential impact of piperacillin–tazobactam administration should also be considered since they may be effective on the development of candidemia. |
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Evaluation of the effect of antibiotics used during parenteral nutrition treatment on CandidemiaParenteral nutritionCandidemiaRisk factorsAntibioticPiperacillin-TazobactamSUMMARY OBJECTIVE: Parenteral nutrition is an important risk factor for candidemia. In this risk analysis study, the effect of previous antibiotic administration apart from the length of hospital stay, duration of Parenteral nutrition treatment, and Candida score parameters on developing candidemia was evaluated in the non-neutropenic patients receiving Parenteral nutrition treatment. METHODS: In this double center, retrospective, and cross-sectional study, the data of patients who received Parenteral nutrition treatment were collected. Patients with or without candidemia after the initiation of Parenteral nutrition treatment were compared in terms of demographic features, Candida score, length of hospital stay, duration of Parenteral nutrition treatment, and previous use of antibiotics. Then, predictor factors affecting the probability of candidemia during Candida growth time were determined by the Cox regression analysis. RESULTS: A total of 148 patients (59.5% males) were included and 16 (10.81%) of these had candidemia after initiation of parenteral nutrition treatment. The median (min–max) duration of parenteral nutrition treatment was 11 (4–72) days and the Candida growth time was 13 (7–29) days. Statistically significant differences were found between patients with or without candidemia groups in terms of length of hospital stay (p<0.001), duration of parenteral nutrition treatment (p<0.001), and Candida score (p<0.001). To determine the effect of these variables and antibiotics on candidemia, length of hospital stay [Hazard Ratio 1.030; p=0.021] and piperacillin–tazobactam (Hazard Ratio 5.626; p=0.030) were found significant and independent risk factors on the development of candidemia. CONCLUSION: There are some well-known risk factors including length of hospital stay, duration of Parenteral nutrition treatment, and Candida score; the potential impact of piperacillin–tazobactam administration should also be considered since they may be effective on the development of candidemia.Associação Médica Brasileira2021-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302021001101448Revista da Associação Médica Brasileira v.67 n.10 2021reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.20210650info:eu-repo/semantics/openAccessYalçın,NadirSürmelioğlu,NurselÖzkan-Kuşcu,ÖzlemKelleci-Çakır,BurcuDemirkan,KutayGündüz,Murateng2021-11-23T00:00:00Zoai:scielo:S0104-42302021001101448Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2021-11-23T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Evaluation of the effect of antibiotics used during parenteral nutrition treatment on Candidemia |
title |
Evaluation of the effect of antibiotics used during parenteral nutrition treatment on Candidemia |
spellingShingle |
Evaluation of the effect of antibiotics used during parenteral nutrition treatment on Candidemia Yalçın,Nadir Parenteral nutrition Candidemia Risk factors Antibiotic Piperacillin-Tazobactam |
title_short |
Evaluation of the effect of antibiotics used during parenteral nutrition treatment on Candidemia |
title_full |
Evaluation of the effect of antibiotics used during parenteral nutrition treatment on Candidemia |
title_fullStr |
Evaluation of the effect of antibiotics used during parenteral nutrition treatment on Candidemia |
title_full_unstemmed |
Evaluation of the effect of antibiotics used during parenteral nutrition treatment on Candidemia |
title_sort |
Evaluation of the effect of antibiotics used during parenteral nutrition treatment on Candidemia |
author |
Yalçın,Nadir |
author_facet |
Yalçın,Nadir Sürmelioğlu,Nursel Özkan-Kuşcu,Özlem Kelleci-Çakır,Burcu Demirkan,Kutay Gündüz,Murat |
author_role |
author |
author2 |
Sürmelioğlu,Nursel Özkan-Kuşcu,Özlem Kelleci-Çakır,Burcu Demirkan,Kutay Gündüz,Murat |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Yalçın,Nadir Sürmelioğlu,Nursel Özkan-Kuşcu,Özlem Kelleci-Çakır,Burcu Demirkan,Kutay Gündüz,Murat |
dc.subject.por.fl_str_mv |
Parenteral nutrition Candidemia Risk factors Antibiotic Piperacillin-Tazobactam |
topic |
Parenteral nutrition Candidemia Risk factors Antibiotic Piperacillin-Tazobactam |
description |
SUMMARY OBJECTIVE: Parenteral nutrition is an important risk factor for candidemia. In this risk analysis study, the effect of previous antibiotic administration apart from the length of hospital stay, duration of Parenteral nutrition treatment, and Candida score parameters on developing candidemia was evaluated in the non-neutropenic patients receiving Parenteral nutrition treatment. METHODS: In this double center, retrospective, and cross-sectional study, the data of patients who received Parenteral nutrition treatment were collected. Patients with or without candidemia after the initiation of Parenteral nutrition treatment were compared in terms of demographic features, Candida score, length of hospital stay, duration of Parenteral nutrition treatment, and previous use of antibiotics. Then, predictor factors affecting the probability of candidemia during Candida growth time were determined by the Cox regression analysis. RESULTS: A total of 148 patients (59.5% males) were included and 16 (10.81%) of these had candidemia after initiation of parenteral nutrition treatment. The median (min–max) duration of parenteral nutrition treatment was 11 (4–72) days and the Candida growth time was 13 (7–29) days. Statistically significant differences were found between patients with or without candidemia groups in terms of length of hospital stay (p<0.001), duration of parenteral nutrition treatment (p<0.001), and Candida score (p<0.001). To determine the effect of these variables and antibiotics on candidemia, length of hospital stay [Hazard Ratio 1.030; p=0.021] and piperacillin–tazobactam (Hazard Ratio 5.626; p=0.030) were found significant and independent risk factors on the development of candidemia. CONCLUSION: There are some well-known risk factors including length of hospital stay, duration of Parenteral nutrition treatment, and Candida score; the potential impact of piperacillin–tazobactam administration should also be considered since they may be effective on the development of candidemia. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302021001101448 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302021001101448 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-9282.20210650 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.67 n.10 2021 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
institution |
AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
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Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
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