Repercussions of melatonin on the risk of breast cancer: a systematic review and meta-analysis
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000500699 |
Resumo: | SUMMARY Breast Cancer is common in women, but its etiology is not yet fully understood. Several factors may contribute to its genesis, such as genetics, lifestyle, and the environment. Melatonin may be involved in the process of breast cancer. Therefore, the aim of this study is to evaluate the influence of the levels of melatonin on breast cancer through a systematic review and meta-analysis. We performed a systematic review according to PRISMA recommendations. The primary databases MEDLINE, Embase, and Cochrane were consulted. There was no restriction on the year of publication and language. Data of systematic reviews from April 2017 to September to 2017 were analyzed. The meta-analysis was conducted using RevMan 5.3 software provided by the Cochrane Collaboration. From a total of 570 articles, 9 manuscripts were included in this review. They analy onzed women with breast cancer and control patients, of which 10% and 90% were in the reproductive period and after menopause, respectively. The lowest level of melatonin was found in approximately 55% of studies with breast cancer in post-menopause. The metanalyses of the studies demonstrated low levels of melatonin in breast cancer patients (n=963) compared with control patients (n= 1332), with a mean difference between the studies of −3.54 (CI −6.01, −1.06). Another difference found was in the comparison between smoking patients, with an average difference between 1.80 [0.97-2.63]. Our data suggest that low levels of melatonin might be a risk factor for breast cancer. |
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Repercussions of melatonin on the risk of breast cancer: a systematic review and meta-analysisMelatoninBreast NeoplasmsReviewRisk factorsMeta-AnalysisSUMMARY Breast Cancer is common in women, but its etiology is not yet fully understood. Several factors may contribute to its genesis, such as genetics, lifestyle, and the environment. Melatonin may be involved in the process of breast cancer. Therefore, the aim of this study is to evaluate the influence of the levels of melatonin on breast cancer through a systematic review and meta-analysis. We performed a systematic review according to PRISMA recommendations. The primary databases MEDLINE, Embase, and Cochrane were consulted. There was no restriction on the year of publication and language. Data of systematic reviews from April 2017 to September to 2017 were analyzed. The meta-analysis was conducted using RevMan 5.3 software provided by the Cochrane Collaboration. From a total of 570 articles, 9 manuscripts were included in this review. They analy onzed women with breast cancer and control patients, of which 10% and 90% were in the reproductive period and after menopause, respectively. The lowest level of melatonin was found in approximately 55% of studies with breast cancer in post-menopause. The metanalyses of the studies demonstrated low levels of melatonin in breast cancer patients (n=963) compared with control patients (n= 1332), with a mean difference between the studies of −3.54 (CI −6.01, −1.06). Another difference found was in the comparison between smoking patients, with an average difference between 1.80 [0.97-2.63]. Our data suggest that low levels of melatonin might be a risk factor for breast cancer.Associação Médica Brasileira2019-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000500699Revista da Associação Médica Brasileira v.65 n.5 2019reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.65.5.699info:eu-repo/semantics/openAccessVeiga,Eduardo Carvalho de ArrudaSimões,RicardoValenti,Vitor ECipolla-Neto,JoseAbreu,Luiz CarlosBarros,Ernane Pedro MatosSorpreso,Isabel Cristina EspositoBaracat,Maria Candido P.Baracat,Edmund CSoares Junior,Jose Mariaeng2019-05-28T00:00:00Zoai:scielo:S0104-42302019000500699Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2019-05-28T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Repercussions of melatonin on the risk of breast cancer: a systematic review and meta-analysis |
title |
Repercussions of melatonin on the risk of breast cancer: a systematic review and meta-analysis |
spellingShingle |
Repercussions of melatonin on the risk of breast cancer: a systematic review and meta-analysis Veiga,Eduardo Carvalho de Arruda Melatonin Breast Neoplasms Review Risk factors Meta-Analysis |
title_short |
Repercussions of melatonin on the risk of breast cancer: a systematic review and meta-analysis |
title_full |
Repercussions of melatonin on the risk of breast cancer: a systematic review and meta-analysis |
title_fullStr |
Repercussions of melatonin on the risk of breast cancer: a systematic review and meta-analysis |
title_full_unstemmed |
Repercussions of melatonin on the risk of breast cancer: a systematic review and meta-analysis |
title_sort |
Repercussions of melatonin on the risk of breast cancer: a systematic review and meta-analysis |
author |
Veiga,Eduardo Carvalho de Arruda |
author_facet |
Veiga,Eduardo Carvalho de Arruda Simões,Ricardo Valenti,Vitor E Cipolla-Neto,Jose Abreu,Luiz Carlos Barros,Ernane Pedro Matos Sorpreso,Isabel Cristina Esposito Baracat,Maria Candido P. Baracat,Edmund C Soares Junior,Jose Maria |
author_role |
author |
author2 |
Simões,Ricardo Valenti,Vitor E Cipolla-Neto,Jose Abreu,Luiz Carlos Barros,Ernane Pedro Matos Sorpreso,Isabel Cristina Esposito Baracat,Maria Candido P. Baracat,Edmund C Soares Junior,Jose Maria |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Veiga,Eduardo Carvalho de Arruda Simões,Ricardo Valenti,Vitor E Cipolla-Neto,Jose Abreu,Luiz Carlos Barros,Ernane Pedro Matos Sorpreso,Isabel Cristina Esposito Baracat,Maria Candido P. Baracat,Edmund C Soares Junior,Jose Maria |
dc.subject.por.fl_str_mv |
Melatonin Breast Neoplasms Review Risk factors Meta-Analysis |
topic |
Melatonin Breast Neoplasms Review Risk factors Meta-Analysis |
description |
SUMMARY Breast Cancer is common in women, but its etiology is not yet fully understood. Several factors may contribute to its genesis, such as genetics, lifestyle, and the environment. Melatonin may be involved in the process of breast cancer. Therefore, the aim of this study is to evaluate the influence of the levels of melatonin on breast cancer through a systematic review and meta-analysis. We performed a systematic review according to PRISMA recommendations. The primary databases MEDLINE, Embase, and Cochrane were consulted. There was no restriction on the year of publication and language. Data of systematic reviews from April 2017 to September to 2017 were analyzed. The meta-analysis was conducted using RevMan 5.3 software provided by the Cochrane Collaboration. From a total of 570 articles, 9 manuscripts were included in this review. They analy onzed women with breast cancer and control patients, of which 10% and 90% were in the reproductive period and after menopause, respectively. The lowest level of melatonin was found in approximately 55% of studies with breast cancer in post-menopause. The metanalyses of the studies demonstrated low levels of melatonin in breast cancer patients (n=963) compared with control patients (n= 1332), with a mean difference between the studies of −3.54 (CI −6.01, −1.06). Another difference found was in the comparison between smoking patients, with an average difference between 1.80 [0.97-2.63]. Our data suggest that low levels of melatonin might be a risk factor for breast cancer. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-05-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000500699 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000500699 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-9282.65.5.699 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.65 n.5 2019 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
institution |
AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
repository.mail.fl_str_mv |
||ramb@amb.org.br |
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