Increase of binucleated cells in the oral mucosa: a study on the use of psychotropics by students of a Brazilian institution
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000600870 |
Resumo: | SUMMARY This study aimed to assess the prevalence of medical and nonmedical use of psychiatric medication among undergraduate students of health sciences from a public university in Brasil. Another objective was to determine the frequency of nuclear morphological abnormalities in the buccal mucosa of students using psychiatric drugs. A cross-sectional study based on a Web survey was carried out with 375 health sciences undergraduate students from schools of Pharmacy, Physical Education, Nutrition, and Medicine. Additionally, spontaneous genetic damages in exfoliated cells of the buccal mucosa of 41 individuals by counting micronucleus (MN) and binucleated (BN) cells frequencies were evaluated. The results showed 76 (20.3%) of students reported the use of psychotropic drugs after enrolling in university. The majority of these students were from Pharmacy and Medicine programs, females, aged between 18-25 years old, nonsmokers, alcohol addicts, and with a family history of mental illness. In addition, Medical students, individuals with high-income, who live alone and are in the last period of the program are more likely to use psychotropic drugs. Moreover, exposure to psychiatric medication was able to increase the number of binucleated cells. These results provide evidence that the use of psychoactive drugs is increased in the academic context and may be related to the failure of the cell cycle. |
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Increase of binucleated cells in the oral mucosa: a study on the use of psychotropics by students of a Brazilian institutionChromosome AberrationsDrugs UtilizationPsychotropic DrugsStudentsSUMMARY This study aimed to assess the prevalence of medical and nonmedical use of psychiatric medication among undergraduate students of health sciences from a public university in Brasil. Another objective was to determine the frequency of nuclear morphological abnormalities in the buccal mucosa of students using psychiatric drugs. A cross-sectional study based on a Web survey was carried out with 375 health sciences undergraduate students from schools of Pharmacy, Physical Education, Nutrition, and Medicine. Additionally, spontaneous genetic damages in exfoliated cells of the buccal mucosa of 41 individuals by counting micronucleus (MN) and binucleated (BN) cells frequencies were evaluated. The results showed 76 (20.3%) of students reported the use of psychotropic drugs after enrolling in university. The majority of these students were from Pharmacy and Medicine programs, females, aged between 18-25 years old, nonsmokers, alcohol addicts, and with a family history of mental illness. In addition, Medical students, individuals with high-income, who live alone and are in the last period of the program are more likely to use psychotropic drugs. Moreover, exposure to psychiatric medication was able to increase the number of binucleated cells. These results provide evidence that the use of psychoactive drugs is increased in the academic context and may be related to the failure of the cell cycle.Associação Médica Brasileira2019-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000600870Revista da Associação Médica Brasileira v.65 n.6 2019reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.65.6.870info:eu-repo/semantics/openAccessOliveira,Luiza Barbosa deParreiras,Joyce Aparecida RezendeSebastião,Elza Conceição de OliveiraSilva,Glenda Nicioli daeng2019-07-22T00:00:00Zoai:scielo:S0104-42302019000600870Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2019-07-22T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Increase of binucleated cells in the oral mucosa: a study on the use of psychotropics by students of a Brazilian institution |
title |
Increase of binucleated cells in the oral mucosa: a study on the use of psychotropics by students of a Brazilian institution |
spellingShingle |
Increase of binucleated cells in the oral mucosa: a study on the use of psychotropics by students of a Brazilian institution Oliveira,Luiza Barbosa de Chromosome Aberrations Drugs Utilization Psychotropic Drugs Students |
title_short |
Increase of binucleated cells in the oral mucosa: a study on the use of psychotropics by students of a Brazilian institution |
title_full |
Increase of binucleated cells in the oral mucosa: a study on the use of psychotropics by students of a Brazilian institution |
title_fullStr |
Increase of binucleated cells in the oral mucosa: a study on the use of psychotropics by students of a Brazilian institution |
title_full_unstemmed |
Increase of binucleated cells in the oral mucosa: a study on the use of psychotropics by students of a Brazilian institution |
title_sort |
Increase of binucleated cells in the oral mucosa: a study on the use of psychotropics by students of a Brazilian institution |
author |
Oliveira,Luiza Barbosa de |
author_facet |
Oliveira,Luiza Barbosa de Parreiras,Joyce Aparecida Rezende Sebastião,Elza Conceição de Oliveira Silva,Glenda Nicioli da |
author_role |
author |
author2 |
Parreiras,Joyce Aparecida Rezende Sebastião,Elza Conceição de Oliveira Silva,Glenda Nicioli da |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Oliveira,Luiza Barbosa de Parreiras,Joyce Aparecida Rezende Sebastião,Elza Conceição de Oliveira Silva,Glenda Nicioli da |
dc.subject.por.fl_str_mv |
Chromosome Aberrations Drugs Utilization Psychotropic Drugs Students |
topic |
Chromosome Aberrations Drugs Utilization Psychotropic Drugs Students |
description |
SUMMARY This study aimed to assess the prevalence of medical and nonmedical use of psychiatric medication among undergraduate students of health sciences from a public university in Brasil. Another objective was to determine the frequency of nuclear morphological abnormalities in the buccal mucosa of students using psychiatric drugs. A cross-sectional study based on a Web survey was carried out with 375 health sciences undergraduate students from schools of Pharmacy, Physical Education, Nutrition, and Medicine. Additionally, spontaneous genetic damages in exfoliated cells of the buccal mucosa of 41 individuals by counting micronucleus (MN) and binucleated (BN) cells frequencies were evaluated. The results showed 76 (20.3%) of students reported the use of psychotropic drugs after enrolling in university. The majority of these students were from Pharmacy and Medicine programs, females, aged between 18-25 years old, nonsmokers, alcohol addicts, and with a family history of mental illness. In addition, Medical students, individuals with high-income, who live alone and are in the last period of the program are more likely to use psychotropic drugs. Moreover, exposure to psychiatric medication was able to increase the number of binucleated cells. These results provide evidence that the use of psychoactive drugs is increased in the academic context and may be related to the failure of the cell cycle. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000600870 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000600870 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-9282.65.6.870 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.65 n.6 2019 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
institution |
AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
repository.mail.fl_str_mv |
||ramb@amb.org.br |
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1754212834250588160 |